Episodes 31-32 | Biomarkers of Accelerated Aging in Severe Mental Illness – With Dr. Lisa Eyler (Parts 1 and 2)

Episode 31:
Severe mental illness (SMI) refers to mental disorders that result in significant functional impairment (e.g., schizophrenia and bipolar disorder). In this episode, we bring you Part 1 of our conversation with Lisa Eyler, Ph.D., about inflammation in individuals with SMI, how inflammation is associated with accelerated aging and other health problems, and the clinical utility of functional magnetic resonance imaging (fMRI) in this population. We also contrast the approaches of the Diagnostic and Statistical Manual of Mental Disorders – Fifth Edition (DSM-5) and the Research Domain Criteria (RDoC).

Episode 32:
We are bringing you the second part of our conversation with Lisa Eyler, Ph.D., on age-related changes in the functional connectivity of individuals with severe mental illness (SMI). Dr. Eyler also summarizes the literature on the biomarkers of SMI in accelerated aging and the clinical utility of these biomarkers independently and in combination with behavioral strategies. After the conversation, we provide our own commentary and discuss the use of biomarkers in clinical practice.

Episode 128 | Functional Cognitive Disorder – With Dr. Laura McWhirter

This episode is a conversation about functional cognitive disorder (FCD) with Dr. Laura McWhirter. The discussion covers preliminary diagnostic criteria, internal inconsistency, epidemiology, clinical features, differential diagnosis with neurodegenerative diseases, common diagnostic pitfalls, etiology/mechanism, metacognition, subjective cognitive concerns, objective cognitive testing, performance validity, genetics and neurobiology, and pushback against FCD as a diagnosis.

Episode 124 | The Neuropsychology of Addiction – With Dr. Antonio Verdejo-Garcia

This episode is a conversation with Dr. Antonio Verdejo-Garcia about the neuropsychology of addiction. We cover addiction epidemiology, the syndrome model, neurobiology, transdiagnostic constructs such as compulsivity, behavioral addictions, cognitive profiles linked to substances of abuse, and behavioral, pharmacological, and cognitive treatments for people with addictions.

Episode 122 | Parkinson’s Disease – With Dr. Sara Schaefer

This episode is a wide ranging discussion of Parkinson’s disease, with Dr. Sara Schaefer. The conversation begins with basic facts, features, and concepts, and then moves into more complex topics, while covering many critical factors for neuropsychologists to consider. It includes a focus on diagnosis/symptoms, epidemiology, core neuropathology, neurodiagnostic approaches, risk factors (e.g., REM behavior disorder), nonmotor features (e.g., autonomic, neuropsychiatric, cognitive), subtypes, and treatment approaches.

Episode 88 | Cannabis and Driving – with Dr. Tom Marcotte

We talk about acute effects of cannabis use (THC) on driving performance with Tom Marcotte, a clinical scientist with decades of experience in this area. We cover the acute cognitive effects of cannabis, the time course of the effects of cannabis on driving performance (based on a driving simulator), the relationship between subjective perceptions of driving performance and actual performance, relevant legal and legislative issues related to cannabis and driving, and differences between recreational and medicinal cannabis on cognition and driving.

Episode 82 | Neuropsychological Norms for Spanish Speaking People in the U.S. – With Dr. Maria Marquine

This episode is a conversation about neuropsychological norms for Spanish speaking people who reside in the U.S. It focuses on the NP-NUMBRS project, which provides norms for a multidomain cognitive battery completed by Spanish speakers from the U.S.-Mexico border region. Additional topics covered include shared aspects of Hispanic/Latinx culture that are relevant to neuropsychologists, the importance of co-normed cognitive batteries in neuropsychology, and cognitive effects of bilingualism, among others.

Episode 63 | COVID-19: The Role of Neuropsychology – With Dr. Chaya Fridman

Emerging research suggests that a sizeable portion of individuals hospitalized due to COVID-19 develop cognitive and psychological sequelae. In our conversation with Dr. Chaya Fridman, a board-certified neuropsychologist at Cornell, we discuss the ways that SARS-CoV-2 (the virus that causes COVID-19) may lead to neurocognitive impairment, including both direct effects of the virus and secondary factors (e.g., respiratory distress and treatments used in the Intensive Care Unit). We review how the virus gains access to the central nervous system and the potential underlying mechanisms by which it causes an increased risk of stroke and other neurological issues. We also examine the long-term effects of prior coronaviruses (SARS-CoV and MERS-CoV) to attempt to forecast the long-term effects of COVID-19, with a focus on how neuropsychological practice (both inpatient and outpatient) might be affected.