Serial neuropsychological assessments are complicated to interpret due to practice effects, regression to the mean, and “normal” change in clinical conditions. Nonetheless, they occur frequently in clinical practice and research. This webinar will compare and contrast the two most widely-used change score methods: Reliable Change Index + Practice Effects (RCI+PE) and Standardized Regression-Based (SRB) change scores. Using actual data in patients with Mild Cognitive Impairment, RCI+PE and SRB will be calculated and compared among subgroups of this sample. Factors that influence RCI+PE and SRB methods will be highlighted, as will methods for using these change scores in clinical practice and research. Although this webinar will be math-heavy, it should allow individuals to immediately start using these change methods in their clinical practice and research.