Culturally informed neuropsychological evaluations require that clinicians develop knowledge of the macrosocietal structures of unfamiliar countries and the cultural backgrounds of their patients. Sub-Saharan Africa is a large region, with over one billion people, some of whom develop neurological conditions and could benefit from neuropsychological services. In this episode, we discuss shared aspects of sub-Saharan culture, particularly in contrast to Western norms, and we introduce and describe the African Neuropsychological Battery. The overarching goal of the episode is to help listeners increase awareness and knowledge of important cultural factors.