In this episode on systematic, non-CNS cancer therapies and brain health, with Drs. Michael Parsons and Jorg Dietrich, we discuss basic concepts in cancer biology, the impact of cancer therapies on cognition, mechanisms by which non-CNS treatments impact brain health, the role of the immune system in treatment, immune system overactivation and cognitive side effects, cancer neuroscience, and the role of neuropsychologists in assessment, management, and treatment of patients with systemic cancers.