INS NYC 2024 Program

Custom Content	Poster Session 11 Program Schedule 02/17/2024 10:45 am - 12:00 pm Room: Shubert Complex (Posters 1-60) Poster Session 11: Cultural Neuropsychology \| Education/Training \| Professional Practice Issues Final Abstract #10 Poster Symposium: Intersecting Determinants of Health: The Influences of Community, sex, race, and Ethnicity in Aging Outcomes, a Health & Aging Brain Study – Health Disparities project — Abstract 3 Associations between neighborhood-level disadvantage and blood-based ATN biomarkers of AD in Hispanic and non-Hispanic older white adults Justin Miller, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States Christina Wong, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States Tasha Rhoads, Cleveland Clinic Neurological Institute, Cleveland, United States Jessica Caldwell, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States Sid O'Bryant, University of North Texas Health Sciences Center, Fort Worth, United States Category: Dementia (Alzheimer's Disease) Keyword 1: dementia - Alzheimer's disease Keyword 2: diversity Keyword 3: minority issues Objective: Individual factors including age, sex, race, and ethnicity have long been included in aging research and have each been associated with Alzheimer’s disease (AD) risk. Although there is a growing body of literature around contextual-level social determinants of health (SDoH), such as neighborhood disadvantage (ND), which is strongly linked to structural and systematic inequities, far less is known about these influences on brain aging, especially for those from diverse backgrounds. As blood-based biomarkers of AD become increasingly available and validated for clinical use and research purposes, it is essential that the influence of contextual determinants of health, and their intersection with race and ethnicity are better understood. Participants and Methods: Data were requested from the Health and Aging Brain Study – Health Disparities (HABS-HD) project, the largest study of aging in a diverse community cohort recruited from the Dallas-Fort Worth metropolitan area. The sample included baseline data from 1,094 non-Hispanic white (NHW) and 1,087 Hispanic older adults. HABS-HD protocols include clinical exams and blood draw, assayed for plasma amyloid (ABeta40 and 42), phosphorolated tau (pTau181), and neurodegeneration (NfL). Neighborhood disadvantage (ND) is assessed using the Area Deprivation Index (ADI) based on the participants current address at the time of visit. Regression models were fit separately for each ethnic group, predicting unadjusted biomarker concentrations individually from age, sex, APoE status, and state-rank ADI (collapsed into quintiles). Results: In the NHW group, ABeta40 was significantly associated with moderate ND (ADI3) and age but not sex, APoE status, or any other ADI quintile. In the Hispanic group, ABeta40 was associated with age and severe ND (ADI5). Moderate ND (ADI3 and ADI4) approached significance, and sex and APoE status were not significant. ABeta42 was associated with age and APoE status, but not sex or ND among NHWs. In the Hispanic group, ABeta42 was also associated with age and APoE status, but not sex or ND. pTau181 was associated with age, sex, and APoE status for both NHWs and Hispanics, but there were no associations with ND in either group. For NfL, age was the only significant predictor; however, in the Hispanic group, moderate (ADI4) and severe (ADI5) ND was significantly associated with NfL in addition to age. Conclusions: Primary blood biomarkers in the ATN framework were associated with age, sex, and APoE status for both Hispanic and non-Hispanic older white adults. There were few associations with neighborhood disadvantage for NHWs, whereas both ABeta 40 and NfL were associated with higher biomarker concentrations in more disadvantaged areas. For both Hispanic and non-Hispanic older white adults, there are important associations with age, though for Hispanic older adults, the community context is an additional factor that must be considered, especially for markers of amyloid and neurodegeneration.

Custom Content

02/17/2024
10:45 am - 12:00 pm
Room: Shubert Complex (Posters 1-60)

Poster Session 11: Cultural Neuropsychology | Education/Training | Professional Practice Issues

Final Abstract #10

Poster Symposium: Intersecting Determinants of Health: The Influences of Community, sex, race, and Ethnicity in Aging Outcomes, a Health & Aging Brain Study – Health Disparities project — Abstract 3

Associations between neighborhood-level disadvantage and blood-based ATN biomarkers of AD in Hispanic and non-Hispanic older white adults

Justin Miller, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States
Christina Wong, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States
Tasha Rhoads, Cleveland Clinic Neurological Institute, Cleveland, United States
Jessica Caldwell, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States
Sid O'Bryant, University of North Texas Health Sciences Center, Fort Worth, United States

Category: Dementia (Alzheimer's Disease)

Keyword 1: dementia - Alzheimer's disease
Keyword 2: diversity
Keyword 3: minority issues

Objective:

Individual factors including age, sex, race, and ethnicity have long been included in aging research and have each been associated with Alzheimer’s disease (AD) risk. Although there is a growing body of literature around contextual-level social determinants of health (SDoH), such as neighborhood disadvantage (ND), which is strongly linked to structural and systematic inequities, far less is known about these influences on brain aging, especially for those from diverse backgrounds. As blood-based biomarkers of AD become increasingly available and validated for clinical use and research purposes, it is essential that the influence of contextual determinants of health, and their intersection with race and ethnicity are better understood.

Participants and Methods:

Data were requested from the Health and Aging Brain Study – Health Disparities (HABS-HD) project, the largest study of aging in a diverse community cohort recruited from the Dallas-Fort Worth metropolitan area. The sample included baseline data from 1,094 non-Hispanic white (NHW) and 1,087 Hispanic older adults. HABS-HD protocols include clinical exams and blood draw, assayed for plasma amyloid (ABeta40 and 42), phosphorolated tau (pTau181), and neurodegeneration (NfL). Neighborhood disadvantage (ND) is assessed using the Area Deprivation Index (ADI) based on the participants current address at the time of visit. Regression models were fit separately for each ethnic group, predicting unadjusted biomarker concentrations individually from age, sex, APoE status, and state-rank ADI (collapsed into quintiles).

Results:

In the NHW group, ABeta40 was significantly associated with moderate ND (ADI3) and age but not sex, APoE status, or any other ADI quintile. In the Hispanic group, ABeta40 was associated with age and severe ND (ADI5). Moderate ND (ADI3 and ADI4) approached significance, and sex and APoE status were not significant. ABeta42 was associated with age and APoE status, but not sex or ND among NHWs. In the Hispanic group, ABeta42 was also associated with age and APoE status, but not sex or ND. pTau181 was associated with age, sex, and APoE status for both NHWs and Hispanics, but there were no associations with ND in either group. For NfL, age was the only significant predictor; however, in the Hispanic group, moderate (ADI4) and severe (ADI5) ND was significantly associated with NfL in addition to age.

Conclusions:

Primary blood biomarkers in the ATN framework were associated with age, sex, and APoE status for both Hispanic and non-Hispanic older white adults. There were few associations with neighborhood disadvantage for NHWs, whereas both ABeta 40 and NfL were associated with higher biomarker concentrations in more disadvantaged areas. For both Hispanic and non-Hispanic older white adults, there are important associations with age, though for Hispanic older adults, the community context is an additional factor that must be considered, especially for markers of amyloid and neurodegeneration.