INS NYC 2024 Program

Custom Content	Poster Session 11 Program Schedule 02/17/2024 10:45 am - 12:00 pm Room: Shubert Complex (Posters 1-60) Poster Session 11: Cultural Neuropsychology \| Education/Training \| Professional Practice Issues Final Abstract #7 Poster Symposium: Intersecting Determinants of Health: The Influences of Community, sex, race, and Ethnicity in Aging Outcomes, a Health & Aging Brain Study – Health Disparities project — Abstract 1 Evaluation of neighborhood-level disadvantage and cognition in Mexican American and non-Hispanic White adults 50 years and older in the US Christina Wong, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States Justin Miller, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States Tasha Rhoads, Neurological Institute, Section of Neuropsychology, Cleveland Clinic, Cleveland, United States Jessica Caldwell, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States Rema Raman, Alzheimer’s Therapeutic Research Institute, University of Southern California, San Diego, United States James Hall, University of North Texas Health Sciences Center, Fort, United States Sid O’Bryant, University of North Texas Health Sciences Center, Fort Worth, United States Category: Inclusion and Diversity/Multiculturalism Keyword 1: cognitive functioning Keyword 2: cross-cultural issues Keyword 3: aging (normal) Objective: Understanding how contextual socioeconomic factors are associated with cognitive aging is important for addressing health disparities in Alzheimer’s disease and related dementias. This study aimed to examine the association of neighborhood disadvantage with cognition among a multiethnic cohort of older adults. Participants and Methods: A total of 853 Mexican American (mean [SD] age, 63.9 [7.9] years; 566 women [66.4%]) and 761 non-Hispanic White adults (mean [SD] age, 69.1 [8.7] years; 414 women [54.4%]) from the Health and Aging Brain Study – Health Disparities were included. Neighborhood disadvantage for participants’ current residence was measured by the Area Deprivation Index (ADI); ADI Texas state deciles were converted to quintiles, with quintile 1 representing the least disadvantaged area and quintile 5 the most disadvantaged area. Cognitive tests included the Spanish-English Verbal Learning Test (SEVLT) Learning and Delayed Recall, Wechsler Memory Scale-Third Edition (WMS-III) Digit Span Forward and Backward, WMS-III Logical Memory I and II, Trail Making Test (TMT) Parts A and B, Animal Naming (semantic fluency), Letter Fluency (phonemic fluency), and Digit Symbol Substitution (DSST). Associations between ADI and neuropsychological performance were examined via demographically adjusted linear regression models stratified by ethnic group. Results: Mexican American participants were more likely to reside in disadvantaged areas, with 280 individuals (32.8%) living in ADI quintile 5, whereas a large proportion of non-Hispanic White participants resided in ADI quintile 1 (296 individuals [38.9%]). Mexican American individuals living in more disadvantaged areas had worse performance than those living in ADI quintile 1 on 7 of 11 cognitive tests, including SEVLT Learning (ADI quintile 5: b = -2.50; 95% CI, -4.46 to -0.54), SEVLT Delayed Recall (eg, ADI quintile 3: b = -1.11; 95% CI, -1.97 to -0.24), Digit Span Forward (eg, ADI quintile 4: b = -1.14; 95% CI, -1.60 to -0.67), TMT part A (ADI quintile 5: b = 7.85; 95% CI, 1.28 to 14.42); TMT part B (eg, ADI quintile 5: b = 31.5; 95% CI, 12.16 to 51.35), Letter Fluency (ADI quintile 4: b = -2.91; 95% CI, -5.39 to -0.43), and DSST (eg, ADI quintile 5: b = -4.45; 95% CI, -6.77 to -2.14). In contrast, only non-Hispanic White individuals living in ADI quintile 4 had worse performance than those living in ADI quintile 1 on 4 of 11 cognitive tests, including SEVLT Learning (b = -2.35; 95% CI, -4.40 to -0.30), SELVT Delayed Recall (b = -0.95; 95% CI, -1.73 to -0.17), TMT part B (b = 15.95; 95% CI, 2.47 to 29.44), and DSST (b = -3.96; 95% CI, -6.49 to -1.43). Conclusions: Aging in a disadvantaged area was associated with worse cognitive functioning, particular for Mexican American older adults. Future studies examining the implications for exposure to neighborhood disadvantage across the life span will be important for improving cognitive outcomes in diverse populations.

Custom Content

02/17/2024
10:45 am - 12:00 pm
Room: Shubert Complex (Posters 1-60)

Poster Session 11: Cultural Neuropsychology | Education/Training | Professional Practice Issues

Final Abstract #7

Poster Symposium: Intersecting Determinants of Health: The Influences of Community, sex, race, and Ethnicity in Aging Outcomes, a Health & Aging Brain Study – Health Disparities project — Abstract 1

Evaluation of neighborhood-level disadvantage and cognition in Mexican American and non-Hispanic White adults 50 years and older in the US

Christina Wong, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States
Justin Miller, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States
Tasha Rhoads, Neurological Institute, Section of Neuropsychology, Cleveland Clinic, Cleveland, United States
Jessica Caldwell, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States
Rema Raman, Alzheimer’s Therapeutic Research Institute, University of Southern California, San Diego, United States
James Hall, University of North Texas Health Sciences Center, Fort, United States
Sid O’Bryant, University of North Texas Health Sciences Center, Fort Worth, United States

Category: Inclusion and Diversity/Multiculturalism

Keyword 1: cognitive functioning
Keyword 2: cross-cultural issues
Keyword 3: aging (normal)

Objective:

Understanding how contextual socioeconomic factors are associated with cognitive aging is important for addressing health disparities in Alzheimer’s disease and related dementias. This study aimed to examine the association of neighborhood disadvantage with cognition among a multiethnic cohort of older adults.

Participants and Methods:

A total of 853 Mexican American (mean [SD] age, 63.9 [7.9] years; 566 women [66.4%]) and 761 non-Hispanic White adults (mean [SD] age, 69.1 [8.7] years; 414 women [54.4%]) from the Health and Aging Brain Study – Health Disparities were included. Neighborhood disadvantage for participants’ current residence was measured by the Area Deprivation Index (ADI); ADI Texas state deciles were converted to quintiles, with quintile 1 representing the least disadvantaged area and quintile 5 the most disadvantaged area. Cognitive tests included the Spanish-English Verbal Learning Test (SEVLT) Learning and Delayed Recall, Wechsler Memory Scale-Third Edition (WMS-III) Digit Span Forward and Backward, WMS-III Logical Memory I and II, Trail Making Test (TMT) Parts A and B, Animal Naming (semantic fluency), Letter Fluency (phonemic fluency), and Digit Symbol Substitution (DSST). Associations between ADI and neuropsychological performance were examined via demographically adjusted linear regression models stratified by ethnic group.

Results:

Mexican American participants were more likely to reside in disadvantaged areas, with 280 individuals (32.8%) living in ADI quintile 5, whereas a large proportion of non-Hispanic White participants resided in ADI quintile 1 (296 individuals [38.9%]). Mexican American individuals living in more disadvantaged areas had worse performance than those living in ADI quintile 1 on 7 of 11 cognitive tests, including SEVLT Learning (ADI quintile 5: b = -2.50; 95% CI, -4.46 to -0.54), SEVLT Delayed Recall (eg, ADI quintile 3: b = -1.11; 95% CI, -1.97 to -0.24), Digit Span Forward (eg, ADI quintile 4: b = -1.14; 95% CI, -1.60 to -0.67), TMT part A (ADI quintile 5: b = 7.85; 95% CI, 1.28 to 14.42); TMT part B (eg, ADI quintile 5: b = 31.5; 95% CI, 12.16 to 51.35), Letter Fluency (ADI quintile 4: b = -2.91; 95% CI, -5.39 to -0.43), and DSST (eg, ADI quintile 5: b = -4.45; 95% CI, -6.77 to -2.14). In contrast, only non-Hispanic White individuals living in ADI quintile 4 had worse performance than those living in ADI quintile 1 on 4 of 11 cognitive tests, including SEVLT Learning (b = -2.35; 95% CI, -4.40 to -0.30), SELVT Delayed Recall (b = -0.95; 95% CI, -1.73 to -0.17), TMT part B (b = 15.95; 95% CI, 2.47 to 29.44), and DSST (b = -3.96; 95% CI, -6.49 to -1.43).

Conclusions:

Aging in a disadvantaged area was associated with worse cognitive functioning, particular for Mexican American older adults. Future studies examining the implications for exposure to neighborhood disadvantage across the life span will be important for improving cognitive outcomes in diverse populations.