INS NYC 2024 Program

Poster	Poster Session 11 Program Schedule 02/17/2024 10:45 am - 12:00 pm Room: Majestic Complex (Posters 61-120) Poster Session 11: Cultural Neuropsychology \| Education/Training \| Professional Practice Issues Final Abstract #111 Differences in Objective Cognitive Performance Among Latinx Older Adults With and Without Subjective Cognitive Decline Zvinka Zlatar, University of California, San Diego, La Jolla, United States Marina Nakhla, San Diego State University and University of California, San Diego Joint Doctoral Program, San Diego, United States María Marquine, Duke University, Durham, United States Douglas Galasko, University of California, San Diego, La Jolla, United States Wassim Tarraf, Wayne State University, Detroit, United States Ranjan Duara, Mount Sinai Medical Center, Miami, United States Warren Barker, Mount Sinai Medical Center, Miami, United States Yaimara Gonzalez Pineiro, Mount Sinai Medical Center, Miami, United States Karen Velasquez De Lopez, Mount Sinai Medical Center, Miami, United States David Salmon, University of California, San Diego, La Jolla, United States Category: Cross Cultural Neuropsychology/ Clinical Cultural Neuroscience Keyword 1: cognitive functioning Keyword 2: memory complaints Keyword 3: minority issues Objective: Subjective cognitive decline (SCD) is a perceived change in cognitive ability over time that may be an early risk marker of Alzheimer’s disease. Although cultural differences in the perception of normal cognitive aging may impact SCD reporting, research on the relationship between self or informant reports of SCD in Latinx older adults and their performance on objective cognitive tests is limited. This study investigated whether or not objective cognitive performance differs in Latinx older adults with or without self-based or informant-based SCD. Participants and Methods: Sixty-five Latinx older adults (mean age=74 years, SD=6.6; mean education=13.6 years, SD=4.4; 67.7% women; 66.2% with Spanish as primary language) without dementia were recruited from the UC San Diego Shiley-Marcos Alzheimer’s Disease Research Center. The Subjective Cognitive Decline Questionnaire (SCD-Q) self (MyCog) and informant (TheirCog) versions were used to assess SCD. Based on the original validation of the SCD-Q, those with scores ≥7 were considered SCD+ and those with scores <7 were considered SCD-. The Uniform Data Set (UDS) version 3 cognitive battery measured objective cognitive performance. Independent samples T-tests compared scores on objective cognitive tests in SCD+ vs. SCD- groups determined by MyCog or TheirCog scores. Results: The MyCog SCD+ group performed worse than the MyCog SCD- group on immediate (16.1 vs. 18.5, t=1.72, df=59.41, one-sided p=.046, Cohen’s d= .41) and delayed verbatim recall of the UDS Story (13.6 vs. 16.8, t=1.92, df=60, one-sided p=.030, Cohen’s d= .5). Moreover, the MyCog SCD+ group was older (76 vs. 72.7, t=-2.05, df=63, one-sided p=.023, Cohen’s d= -.52) and had higher Geriatric Depression Scale (GDS) scores (1.69 versus .69, t=-2.4, df=33.08, one-sided p=.012, Cohen’s d= -.68) than the MyCog SCD- group. The TheirCog SCD+ group also scored lower than the TheirCog SCD- group on the immediate (15.3 vs. 18.5, t=1.86, df=52, one-sided p=.035, Cohen’s d= .55) and delayed verbatim recall conditions of the UDS Story task (13.3 vs. 16.6, t=1.73, df=52, one-sided p=.045, Cohen’s d= .52); however, the TheirCog defined groups did not differ on age, education, or GDS scores. Conclusions: Both the MyCog and TheirCog versions of the SCD-Q detected cognitive differences at a cutoff of ≥7 that were verified against objective memory performance amongst Latinx older adults. While both methods were effective at detecting memory differences, there may be a larger influence of participant’s age and depressive symptoms in self-based than in informant-based reporting of SCD among Latinx older adults living in Southern California.

Poster

02/17/2024
10:45 am - 12:00 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 11: Cultural Neuropsychology | Education/Training | Professional Practice Issues

Final Abstract #111

Differences in Objective Cognitive Performance Among Latinx Older Adults With and Without Subjective Cognitive Decline

Zvinka Zlatar, University of California, San Diego, La Jolla, United States
Marina Nakhla, San Diego State University and University of California, San Diego Joint Doctoral Program, San Diego, United States
María Marquine, Duke University, Durham, United States
Douglas Galasko, University of California, San Diego, La Jolla, United States
Wassim Tarraf, Wayne State University, Detroit, United States
Ranjan Duara, Mount Sinai Medical Center, Miami, United States
Warren Barker, Mount Sinai Medical Center, Miami, United States
Yaimara Gonzalez Pineiro, Mount Sinai Medical Center, Miami, United States
Karen Velasquez De Lopez, Mount Sinai Medical Center, Miami, United States
David Salmon, University of California, San Diego, La Jolla, United States

Category: Cross Cultural Neuropsychology/ Clinical Cultural Neuroscience

Keyword 1: cognitive functioning
Keyword 2: memory complaints
Keyword 3: minority issues

Objective:

Subjective cognitive decline (SCD) is a perceived change in cognitive ability over time that may be an early risk marker of Alzheimer’s disease. Although cultural differences in the perception of normal cognitive aging may impact SCD reporting, research on the relationship between self or informant reports of SCD in Latinx older adults and their performance on objective cognitive tests is limited. This study investigated whether or not objective cognitive performance differs in Latinx older adults with or without self-based or informant-based SCD.

Participants and Methods:

Sixty-five Latinx older adults (mean age=74 years, SD=6.6; mean education=13.6 years, SD=4.4; 67.7% women; 66.2% with Spanish as primary language) without dementia were recruited from the UC San Diego Shiley-Marcos Alzheimer’s Disease Research Center. The Subjective Cognitive Decline Questionnaire (SCD-Q) self (MyCog) and informant (TheirCog) versions were used to assess SCD. Based on the original validation of the SCD-Q, those with scores ≥7 were considered SCD+ and those with scores <7 were considered SCD-. The Uniform Data Set (UDS) version 3 cognitive battery measured objective cognitive performance. Independent samples T-tests compared scores on objective cognitive tests in SCD+ vs. SCD- groups determined by MyCog or TheirCog scores.

Results:

The MyCog SCD+ group performed worse than the MyCog SCD- group on immediate (16.1 vs. 18.5, t=1.72, df=59.41, one-sided p=.046, Cohen’s d= .41) and delayed verbatim recall of the UDS Story (13.6 vs. 16.8, t=1.92, df=60, one-sided p=.030, Cohen’s d= .5). Moreover, the MyCog SCD+ group was older (76 vs. 72.7, t=-2.05, df=63, one-sided p=.023, Cohen’s d= -.52) and had higher Geriatric Depression Scale (GDS) scores (1.69 versus .69, t=-2.4, df=33.08, one-sided p=.012, Cohen’s d= -.68) than the MyCog SCD- group. The TheirCog SCD+ group also scored lower than the TheirCog SCD- group on the immediate (15.3 vs. 18.5, t=1.86, df=52, one-sided p=.035, Cohen’s d= .55) and delayed verbatim recall conditions of the UDS Story task (13.3 vs. 16.6, t=1.73, df=52, one-sided p=.045, Cohen’s d= .52); however, the TheirCog defined groups did not differ on age, education, or GDS scores.

Conclusions:

Both the MyCog and TheirCog versions of the SCD-Q detected cognitive differences at a cutoff of ≥7 that were verified against objective memory performance amongst Latinx older adults. While both methods were effective at detecting memory differences, there may be a larger influence of participant’s age and depressive symptoms in self-based than in informant-based reporting of SCD among Latinx older adults living in Southern California.