INS NYC 2024 Program

Poster	Poster Session 11 Program Schedule 02/17/2024 10:45 am - 12:00 pm Room: Majestic Complex (Posters 61-120) Poster Session 11: Cultural Neuropsychology \| Education/Training \| Professional Practice Issues Final Abstract #21 Normative data for the cognitively unimpaired oldest-old from Colombia Daniel Vasquez, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia Yesica Zuluaga, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia Ana Baena, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia Liliana Hincapie, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia David Aguillon, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia Lucia Madrigal, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia Joseph Arboleda-Velasquez, Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, United States Francisco Lopera, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia Yakeel Quiroz, 3. Department of Psychiatry at Harvard Medical School, Boston, United States Category: Aging Keyword 1: aging (normal) Keyword 2: psychometrics Keyword 3: cognitive screening Objective: With the aging of the world's population, age-related disorders such as dementia due to Alzheimer's disease and other causes are becoming increasingly prevalent. This has led to an increased interest in the prevention of these diseases and promotion of healthy aging. Considering the variability in cognitive test performance mediated by cultural differences, it is relevant to have culturally appropriate cut-off points to guide the interpretation of cognitive performance. Unfortunately, existing normative data on neuropsychological measures for Colombians only go until late 60s, leaving out individuals over 80 years of age. Thus, this study aimed to provide oldest-old (>80+ years) normative data in a Colombian population. Participants and Methods: All participants were individuals over 80 years of age and cognitively unimpaired. All participants had separate medical and neuropsychological assessments to define their cognitive status. When inconsistencies occurred, the case was discussed among the group of investigators to reach a consensus. Those who did not perform all the tests due to fatigue or sensory disability were not excluded and these were recorded as missing data. Neuropsychological evaluations were conducted between April 2021 and May 2023 with a Spanish neuropsychological test battery used by the Group of Neuroscience of Antioquia. The battery included tests for cognitive screening, memory, language, visuospatial functioning, executive functioning, and processing speed, adapted for this population. Results: Of all, 31 were female (76%), the median of years of education was 7 (IQR 7), and the mean age was 89.6±5.87. Normative data for all participants in all measures are presented. On the cognitive screening tests, the mean MMSE was 25±2/30. The mean number of animal naming in semantic fluency was 12±4.3 and the mean on the 15-item Boston Naming Test was 10.3±2.3. In the memory tests, the mean CERAD Word List Learning score was 12.2±3.3/30, for Delayed Recall was 2.88±1.6/10, and for Recognition was 7.9±1.9/10. From the visuospatial assessment, the mean for the CERAD Constructional Praxis subtest was 6.48± 2/11 and for Praxis Recall was 3.5±2.9/11. On processing speed, the mean time for TMT-A was 155 sec± 35.4, max. 180 sec, and the number of correct was 20.6±5.2/24. The mean score for semi-complex figure copying was 8.6±2.3/12 and for recall was 3.2±2.7/12. The mean score for phonemic fluency (FAS) was 24.7±11, and for the Raven-A test was 7±1.7/12. In the "A" cancellation test (continuous visual execution), the mean score for hits was 13.7±2.3, and for omissions was 2.3±2.3. In addition, the mean score on the digit retention test was 5.9±1.5/16 forward, 3.44±1.5/14 backward, and 9.3±2.3/30 overall. Conclusions: To our knowledge, this is the first study to present normative data for neuropsychological measures in a Colombian population over 80 years of age. Future research should use these data to assess and further characterize the oldest old cognitive functioning and establish cut off for cognitive impairment at these older ages.

Poster

02/17/2024
10:45 am - 12:00 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 11: Cultural Neuropsychology | Education/Training | Professional Practice Issues

Final Abstract #21

Normative data for the cognitively unimpaired oldest-old from Colombia

Daniel Vasquez, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia
Yesica Zuluaga, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia
Ana Baena, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia
Liliana Hincapie, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia
David Aguillon, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia
Lucia Madrigal, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia
Joseph Arboleda-Velasquez, Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, United States
Francisco Lopera, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia
Yakeel Quiroz, 3. Department of Psychiatry at Harvard Medical School, Boston, United States

Category: Aging

Keyword 1: aging (normal)
Keyword 2: psychometrics
Keyword 3: cognitive screening

Objective:

With the aging of the world's population, age-related disorders such as dementia due to Alzheimer's disease and other causes are becoming increasingly prevalent. This has led to an increased interest in the prevention of these diseases and promotion of healthy aging. Considering the variability in cognitive test performance mediated by cultural differences, it is relevant to have culturally appropriate cut-off points to guide the interpretation of cognitive performance. Unfortunately, existing normative data on neuropsychological measures for Colombians only go until late 60s, leaving out individuals over 80 years of age. Thus, this study aimed to provide oldest-old (>80+ years) normative data in a Colombian population.

Participants and Methods:

All participants were individuals over 80 years of age and cognitively unimpaired. All participants had separate medical and neuropsychological assessments to define their cognitive status. When inconsistencies occurred, the case was discussed among the group of investigators to reach a consensus. Those who did not perform all the tests due to fatigue or sensory disability were not excluded and these were recorded as missing data. Neuropsychological evaluations were conducted between April 2021 and May 2023 with a Spanish neuropsychological test battery used by the Group of Neuroscience of Antioquia. The battery included tests for cognitive screening, memory, language, visuospatial functioning, executive functioning, and processing speed, adapted for this population.

Results:

Of all, 31 were female (76%), the median of years of education was 7 (IQR 7), and the mean age was 89.6±5.87. Normative data for all participants in all measures are presented. On the cognitive screening tests, the mean MMSE was 25±2/30. The mean number of animal naming in semantic fluency was 12±4.3 and the mean on the 15-item Boston Naming Test was 10.3±2.3. In the memory tests, the mean CERAD Word List Learning score was 12.2±3.3/30, for Delayed Recall was 2.88±1.6/10, and for Recognition was 7.9±1.9/10. From the visuospatial assessment, the mean for the CERAD Constructional Praxis subtest was 6.48± 2/11 and for Praxis Recall was 3.5±2.9/11. On processing speed, the mean time for TMT-A was 155 sec± 35.4, max. 180 sec, and the number of correct was 20.6±5.2/24. The mean score for semi-complex figure copying was 8.6±2.3/12 and for recall was 3.2±2.7/12. The mean score for phonemic fluency (FAS) was 24.7±11, and for the Raven-A test was 7±1.7/12. In the "A" cancellation test (continuous visual execution), the mean score for hits was 13.7±2.3, and for omissions was 2.3±2.3. In addition, the mean score on the digit retention test was 5.9±1.5/16 forward, 3.44±1.5/14 backward, and 9.3±2.3/30 overall.

Conclusions:

To our knowledge, this is the first study to present normative data for neuropsychological measures in a Colombian population over 80 years of age. Future research should use these data to assess and further characterize the oldest old cognitive functioning and establish cut off for cognitive impairment at these older ages.