INS NYC 2024 Program

Poster	Poster Session 11 Program Schedule 02/17/2024 10:45 am - 12:00 pm Room: Majestic Complex (Posters 61-120) Poster Session 11: Cultural Neuropsychology \| Education/Training \| Professional Practice Issues Final Abstract #75 The Role of Discrimination in Sleep Disruption and ADRD Plasma Biomarkers among Racial/Ethnic Groups Obinnaya Onwukanjo, Columbia University Irving Medical Center, New York, United States Emily Hokett, Columbia University Irving Medical Center, New York, United States Patrick Lao, Columbia University Irving Medical Center, New York, United States Indira Turney, Columbia University Irving Medical Center, New York, United States Mathieu Herman, Columbia University Irving Medical Center, New York, United States Dejania Cotton-Samuel, Columbia University Irving Medical Center, New York, United States Sabrina Simoes, Columbia University Irving Medical Center, New York, United States Adam Brickman, Columbia University Irving Medical Center, New York, United States Jennifer Manly, Columbia University Irving Medical Center, New York, United States Category: Sleep and Sleep Disorders Keyword 1: sleep Keyword 2: dementia - Alzheimer's disease Objective: Sleep is a modifiable factor that may alter the progression of Alzheimer’s and Related Dementias (ADRD). Individuals from minoritized racial and ethnic backgrounds, including Black and Latinx people, are at high risk for both ADRD and sleep disruption. This study investigated associations between discrimination and self-reported sleep disruption among middle aged adults. Additionally, we assessed associations between sleep disruption and ADRD biomarkers by gender and racial and ethnic identity. Participants and Methods: This study used data from 2015 participants in the Offspring Study of Racial and Ethnic Disparities in Alzheimer’s Disease, an ongoing research study collecting data from middle-aged adults (Mean age = 56.4 years, SD = 11.2, 66.6% women). Participants completed the Pittsburgh Sleep Quality Index (PSQI) and the Everyday Discrimination Scale. Two of the PSQI’s components were used in the present study: sleep duration and sleep disturbance. The sleep duration subscale measured the participants’ sleep hours over the past month. Sleep disturbance was used to measure quality. The aggregate score for this component is based on the frequency of sleep disturbances and could range from 0-27. The Everyday Discrimination Scale similarly measured the frequency of daily interpersonal experiences of discrimination. We used chronicity coding to score the scale, a coding method that captures the chronic stress that stems from discrimination. Scores on this measure ranged from 0-2600, with 0 indicating no experiences of discrimination within the last year and 2600 indicating many experiences of daily discrimination. Blood-based ADRD biomarkers, including amyloid (Aß42/Aß40), phosphor-tau181 (p-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP), were measured with Simoa assays. We used multiple linear regressions to test associations between discrimination and the sleep measures, discrimination and ADRD biomarkers, and the sleep measures and ADRD biomarkers. We stratified by racial/ethnic and gender identity group, and education and age were included in the analysis as covariates. Results: Sleep disruption was associated with ADRD biomarkers in Black women, Latinx men and Latinx women. Higher sleep disturbance was associated with a lower Aß42/Aß40 ratio in Black women (indicating higher amyloid burden), tau in Latinx women, and NfL in Latinx men. Furthermore, shorter sleep duration was associated with higher tau and NfL in Latinx women. Conversely, longer sleep duration was associated with higher NfL in Latinx men. There was no relationship between experiences of discrimination and ADRD biomarkers or sleep disruption. Conclusions: These findings emphasize the importance of consistent, high quality sleep for brain health. Moreover, both oversleeping and inadequate sleep duration may be associated indicators with ADRD risk. While we were not able to establish a relationship between discrimination and sleep disruption or ADRD biomarkers, more research is warranted to properly understand the mechanisms behind higher rates of sleep disruption and poorer brain health among minoritized individuals.

Poster

02/17/2024
10:45 am - 12:00 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 11: Cultural Neuropsychology | Education/Training | Professional Practice Issues

Final Abstract #75

The Role of Discrimination in Sleep Disruption and ADRD Plasma Biomarkers among Racial/Ethnic Groups

Obinnaya Onwukanjo, Columbia University Irving Medical Center, New York, United States
Emily Hokett, Columbia University Irving Medical Center, New York, United States
Patrick Lao, Columbia University Irving Medical Center, New York, United States
Indira Turney, Columbia University Irving Medical Center, New York, United States
Mathieu Herman, Columbia University Irving Medical Center, New York, United States
Dejania Cotton-Samuel, Columbia University Irving Medical Center, New York, United States
Sabrina Simoes, Columbia University Irving Medical Center, New York, United States
Adam Brickman, Columbia University Irving Medical Center, New York, United States
Jennifer Manly, Columbia University Irving Medical Center, New York, United States

Category: Sleep and Sleep Disorders

Keyword 1: sleep
Keyword 2: dementia - Alzheimer's disease

Objective:

Sleep is a modifiable factor that may alter the progression of Alzheimer’s and Related Dementias (ADRD). Individuals from minoritized racial and ethnic backgrounds, including Black and Latinx people, are at high risk for both ADRD and sleep disruption. This study investigated associations between discrimination and self-reported sleep disruption among middle aged adults. Additionally, we assessed associations between sleep disruption and ADRD biomarkers by gender and racial and ethnic identity.

Participants and Methods:

This study used data from 2015 participants in the Offspring Study of Racial and Ethnic Disparities in Alzheimer’s Disease, an ongoing research study collecting data from middle-aged adults (Mean age = 56.4 years, SD = 11.2, 66.6% women). Participants completed the Pittsburgh Sleep Quality Index (PSQI) and the Everyday Discrimination Scale. Two of the PSQI’s components were used in the present study: sleep duration and sleep disturbance. The sleep duration subscale measured the participants’ sleep hours over the past month. Sleep disturbance was used to measure quality. The aggregate score for this component is based on the frequency of sleep disturbances and could range from 0-27. The Everyday Discrimination Scale similarly measured the frequency of daily interpersonal experiences of discrimination. We used chronicity coding to score the scale, a coding method that captures the chronic stress that stems from discrimination. Scores on this measure ranged from 0-2600, with 0 indicating no experiences of discrimination within the last year and 2600 indicating many experiences of daily discrimination. Blood-based ADRD biomarkers, including amyloid (Aß42/Aß40), phosphor-tau181 (p-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP), were measured with Simoa assays. We used multiple linear regressions to test associations between discrimination and the sleep measures, discrimination and ADRD biomarkers, and the sleep measures and ADRD biomarkers. We stratified by racial/ethnic and gender identity group, and education and age were included in the analysis as covariates.

Results:

Sleep disruption was associated with ADRD biomarkers in Black women, Latinx men and Latinx women. Higher sleep disturbance was associated with a lower Aß42/Aß40 ratio in Black women (indicating higher amyloid burden), tau in Latinx women, and NfL in Latinx men. Furthermore, shorter sleep duration was associated with higher tau and NfL in Latinx women. Conversely, longer sleep duration was associated with higher NfL in Latinx men. There was no relationship between experiences of discrimination and ADRD biomarkers or sleep disruption.

Conclusions:

These findings emphasize the importance of consistent, high quality sleep for brain health. Moreover, both oversleeping and inadequate sleep duration may be associated indicators with ADRD risk. While we were not able to establish a relationship between discrimination and sleep disruption or ADRD biomarkers, more research is warranted to properly understand the mechanisms behind higher rates of sleep disruption and poorer brain health among minoritized individuals.