INS NYC 2024 Program

Poster	Poster Session 11 Program Schedule 02/17/2024 10:45 am - 12:00 pm Room: Shubert Complex (Posters 1-60) Poster Session 11: Cultural Neuropsychology \| Education/Training \| Professional Practice Issues Final Abstract #42 The Relationship Between Cardiovascular Risk Factors and Cognition in a Sample of Chinese American Older Adults in the New York Metropolitan Area Alexandra Groome, Mount Sinai Icahn School of Medicine, New York, United States Clara Li, Mount Sinai Icahn School of Medicine, New York, United States Jessica Spat-Lemus, Montclair State University, Montclair, United States Doris Hong, Mass General Brigham Salem Hospital, Salem, United States Tianxu Xia, Mount Sinai Icahn School of Medicine, New York, United States Judith Neugroschl, Mount Sinai Icahn School of Medicine, New York, United States Category: Dementia (Non-AD) Keyword 1: vascular dementia Keyword 2: memory disorders Keyword 3: cardiovascular disease Objective: Although there are more than 5 million Chinese Americans living in the United States, they are a historically underrepresented group in research concerning Alzheimer’s Disease Related Dementias (ADRD). As a whole, several studies have noted disproportionally high cardiovascular risk factors, such as stroke, in Chinese Americans, which can confer greater susceptibility to ADRD. Unfortunately, there are few studies with conclusive evidence concerning the rate of vascular-related dementia in this population (Bell et al., 2017; Stephan & Siervo, 2020; Yang et al., 2016). As such, the present study aimed to understand the relationship between vascular risk factors and global cognitive status in Chinese American older adults. We utilized the Stoke Risk Profile developed by the Framingham study, which is the most widely used prediction tool for stroke risk (Wolf et al., 1991). More specifically, the present pilot study examined the relationship between the Framingham Stroke Risk Profile (FSRP) and performance on cognitive screeners in Chinese American older adults in the NY metropolitan area. Participants and Methods: A cohort of 181 Mandarin or Cantonese-speaking adults with mixed clinical neurocognitive diagnoses (i.e., normal control and those with neurocognitive decline), who were > 55 years old, were recruited at the Alzheimer’s Disease Research Center at Mount Sinai. All participants underwent a clinical interview/medical exam by a study physician and completed a comprehensive cognitive battery in either Mandarin or Cantonese. A cardiovascular risk composite was constructed based on the FSRP and involved a point system based on sex, age, systolic blood pressure, history of diabetes, current cigarette smoking, prevalent cardiovascular disease, and history of atrial fibrillation. Objective cognitive performance (MoCA) and clinician-rated cognitive status (CDR-SB) were used as outcome variables. The relationships between cardiovascular risk and cognitive outcomes were examined using multivariate regressions. Results: Participants were primarily female (64%), Mandarin speaking (60%), with mean years of living in the U.S. of 32.9±14.2 years. The mean age was 74.2±7.6 years and education was 12.4±4.4 years. 55.2% of the cohort were determined to be cognitively healthy, 27.1% were diagnosed with MCI, and 17.7% with dementia. In this cohort, the cardiovascular risk composite significantly predicted MoCA total score and CDR-SUM score. The significant predictive effects held when additional demographic control variables were added (i.e., education, language, duration of immigration). Conclusions: Consistent with the literature in this area, the current study found that higher cardiovascular risk factors were associated with poor global cognitive status in a sample of Chinese American older adults. Future research should involve a larger sample of Chinese American older adults to determine if the current findings can be replicated. However, results from this pilot study suggest that intervention strategies should incorporate reducing modifiable cardiovascular risk factors in this population.

Poster

02/17/2024
10:45 am - 12:00 pm
Room: Shubert Complex (Posters 1-60)

Poster Session 11: Cultural Neuropsychology | Education/Training | Professional Practice Issues

Final Abstract #42

The Relationship Between Cardiovascular Risk Factors and Cognition in a Sample of Chinese American Older Adults in the New York Metropolitan Area

Alexandra Groome, Mount Sinai Icahn School of Medicine, New York, United States
Clara Li, Mount Sinai Icahn School of Medicine, New York, United States
Jessica Spat-Lemus, Montclair State University, Montclair, United States
Doris Hong, Mass General Brigham Salem Hospital, Salem, United States
Tianxu Xia, Mount Sinai Icahn School of Medicine, New York, United States
Judith Neugroschl, Mount Sinai Icahn School of Medicine, New York, United States

Category: Dementia (Non-AD)

Keyword 1: vascular dementia
Keyword 2: memory disorders
Keyword 3: cardiovascular disease

Objective:

Although there are more than 5 million Chinese Americans living in the United States, they are a historically underrepresented group in research concerning Alzheimer’s Disease Related Dementias (ADRD). As a whole, several studies have noted disproportionally high cardiovascular risk factors, such as stroke, in Chinese Americans, which can confer greater susceptibility to ADRD. Unfortunately, there are few studies with conclusive evidence concerning the rate of vascular-related dementia in this population (Bell et al., 2017; Stephan & Siervo, 2020; Yang et al., 2016). As such, the present study aimed to understand the relationship between vascular risk factors and global cognitive status in Chinese American older adults. We utilized the Stoke Risk Profile developed by the Framingham study, which is the most widely used prediction tool for stroke risk (Wolf et al., 1991). More specifically, the present pilot study examined the relationship between the Framingham Stroke Risk Profile (FSRP) and performance on cognitive screeners in Chinese American older adults in the NY metropolitan area.

Participants and Methods:

A cohort of 181 Mandarin or Cantonese-speaking adults with mixed clinical neurocognitive diagnoses (i.e., normal control and those with neurocognitive decline), who were > 55 years old, were recruited at the Alzheimer’s Disease Research Center at Mount Sinai. All participants underwent a clinical interview/medical exam by a study physician and completed a comprehensive cognitive battery in either Mandarin or Cantonese. A cardiovascular risk composite was constructed based on the FSRP and involved a point system based on sex, age, systolic blood pressure, history of diabetes, current cigarette smoking, prevalent cardiovascular disease, and history of atrial fibrillation. Objective cognitive performance (MoCA) and clinician-rated cognitive status (CDR-SB) were used as outcome variables. The relationships between cardiovascular risk and cognitive outcomes were examined using multivariate regressions.

Results:

Participants were primarily female (64%), Mandarin speaking (60%), with mean years of living in the U.S. of 32.9±14.2 years. The mean age was 74.2±7.6 years and education was 12.4±4.4 years. 55.2% of the cohort were determined to be cognitively healthy, 27.1% were diagnosed with MCI, and 17.7% with dementia. In this cohort, the cardiovascular risk composite significantly predicted MoCA total score and CDR-SUM score. The significant predictive effects held when additional demographic control variables were added (i.e., education, language, duration of immigration).

Conclusions:

Consistent with the literature in this area, the current study found that higher cardiovascular risk factors were associated with poor global cognitive status in a sample of Chinese American older adults. Future research should involve a larger sample of Chinese American older adults to determine if the current findings can be replicated. However, results from this pilot study suggest that intervention strategies should incorporate reducing modifiable cardiovascular risk factors in this population.