INS NYC 2024 Program

Poster	Poster Session 10 Program Schedule 02/17/2024 09:00 am - 10:15 am Room: Majestic Complex (Posters 61-120) Poster Session 10: Neurodevelopmental \| Congenital Conditions Final Abstract #92 Preliminary Analyses of Cognition in Children with Suspected Substance Exposure In-Utero: Do Bayley-3 Scores Predict Future Performance on the WPPSI-IV? Jessie Tibbs, Oklahoma City VA, Oklahoma City, United States Analise Roccaforte, Baptist Health, Jacksonville, United States Bridget Barnett, The University of Oklahoma Health Sciences Center, Oklahoma City, United States Elizabeth Bard, The University of Oklahoma Health Sciences Center, Oklahoma City, United States Category: Prenatal/Perinatal Factors/Prematurity Keyword 1: assessment Keyword 2: drug / toxin-related disorders Keyword 3: child development disorders Objective: Substance exposure in-utero can result in a myriad of negative developmental effects, including motor and speech delays, emotional and behavioral dysregulation, and cognitive dysfunction. Research indicates that early identification of such effects is essential to guide necessary early intervention. Evaluations ideally involve comprehensive assessment of motor, speech, emotional, behavioral, and cognitive development, with appropriate follow-up as the child matures to ensure identification of various difficulties that may arise at different stages of development. The Bayley Scales of Infant Development (BSID) is commonly used to assess cognitive (and other areas of) development in infants and early toddlers. The Wechsler Preschool and Primary Scale of Intelligence (WPPSI) is a gold-standard tool for assessing cognition during early childhood. Research has found that scores on the cognitive subscale of the Bayley typically correlate with cognition in early childhood. However, the predictive value of the BSID in children exposed to substances in-utero has not been empirically tested. Thus, the primary objective of the present study was to examine whether performance on the Bayley-III predicted later performance on the WPPSI-IV in children with suspected exposure to substances in-utero. Participants and Methods: 104 children (39.4% female; 12.5% Black, 38.5% white, 41.3% Multiracial, 4.8% Native American, 1.9% Hispanic, 1% Asian), were assessed between March 2009 and April 2021 with the BSID 3rd Edition (Bayley-3) and WPPSI 4th Edition (WPPSI-IV) at two separate time points as part of a larger clinical comprehensive interdisciplinary developmental assessment in the context of suspected substance exposure in-utero. Children were assessed using the Bayley-3 at approximately 26.2 months (SD = 6.36 months) and either the WPPSI-IV Ages 2:6-3:11 form (N = 76) at approximately 39.17 months (SD = 4.36 months) or the WPPSI-IV Ages 4:00-7:7 form (N = 28) at approximately 54.96 months (SD = 7.70 months), depending on age. Current primary caregivers (44.9% adoptive mothers) were also interviewed regarding the child’s developmental and medical history, current physical, emotional, and cognitive functioning, and knowledge of biological parents’ substance use, including substance use during pregnancy. Results: Pearson’s correlations revealed significant (p<.05) positive bivariate relationships between Bayley-3 cognitive composite scores and: WPPSI-IV verbal comprehension, visual spatial, and full scale IQ composite scores (for both WPPSI-IV age bands). Bayley-3 cognitive scores were not significantly correlated with WPPSI-IV working memory composite scores. Maternal substance use did not significantly correlate with Bayley-3 or WPPSI-IV composite scores. Multiple linear regression analyses indicated that Bayley-3 cognitive composite scores significantly (p<.05) predicted WPPSI-IV verbal comprehension, visual spatial, and full-scale IQ composite scores, but did not significantly predict working memory composite scores. Conclusions: Taken together, results suggest that the Bayley-3 cognitive scale is a significant predictor of future verbal, visuospatial, and global cognitive scores during early childhood in children with suspected in-utero substance exposure. This research coincides with research in other pediatric populations (e.g., children born pre-term, non-clinical typically developing children). Implications, future directions, and study limitations are further explored.

Poster

02/17/2024
09:00 am - 10:15 am
Room: Majestic Complex (Posters 61-120)

Poster Session 10: Neurodevelopmental | Congenital Conditions

Final Abstract #92

Preliminary Analyses of Cognition in Children with Suspected Substance Exposure In-Utero: Do Bayley-3 Scores Predict Future Performance on the WPPSI-IV?

Jessie Tibbs, Oklahoma City VA, Oklahoma City, United States
Analise Roccaforte, Baptist Health, Jacksonville, United States
Bridget Barnett, The University of Oklahoma Health Sciences Center, Oklahoma City, United States
Elizabeth Bard, The University of Oklahoma Health Sciences Center, Oklahoma City, United States

Category: Prenatal/Perinatal Factors/Prematurity

Keyword 1: assessment
Keyword 2: drug / toxin-related disorders
Keyword 3: child development disorders

Objective:

Substance exposure in-utero can result in a myriad of negative developmental effects, including motor and speech delays, emotional and behavioral dysregulation, and cognitive dysfunction. Research indicates that early identification of such effects is essential to guide necessary early intervention. Evaluations ideally involve comprehensive assessment of motor, speech, emotional, behavioral, and cognitive development, with appropriate follow-up as the child matures to ensure identification of various difficulties that may arise at different stages of development. The Bayley Scales of Infant Development (BSID) is commonly used to assess cognitive (and other areas of) development in infants and early toddlers. The Wechsler Preschool and Primary Scale of Intelligence (WPPSI) is a gold-standard tool for assessing cognition during early childhood. Research has found that scores on the cognitive subscale of the Bayley typically correlate with cognition in early childhood. However, the predictive value of the BSID in children exposed to substances in-utero has not been empirically tested. Thus, the primary objective of the present study was to examine whether performance on the Bayley-III predicted later performance on the WPPSI-IV in children with suspected exposure to substances in-utero.

Participants and Methods:

104 children (39.4% female; 12.5% Black, 38.5% white, 41.3% Multiracial, 4.8% Native American, 1.9% Hispanic, 1% Asian), were assessed between March 2009 and April 2021 with the BSID 3rd Edition (Bayley-3) and WPPSI 4th Edition (WPPSI-IV) at two separate time points as part of a larger clinical comprehensive interdisciplinary developmental assessment in the context of suspected substance exposure in-utero. Children were assessed using the Bayley-3 at approximately 26.2 months (SD = 6.36 months) and either the WPPSI-IV Ages 2:6-3:11 form (N = 76) at approximately 39.17 months (SD = 4.36 months) or the WPPSI-IV Ages 4:00-7:7 form (N = 28) at approximately 54.96 months (SD = 7.70 months), depending on age. Current primary caregivers (44.9% adoptive mothers) were also interviewed regarding the child’s developmental and medical history, current physical, emotional, and cognitive functioning, and knowledge of biological parents’ substance use, including substance use during pregnancy.

Results:

Pearson’s correlations revealed significant (p<.05) positive bivariate relationships between Bayley-3 cognitive composite scores and: WPPSI-IV verbal comprehension, visual spatial, and full scale IQ composite scores (for both WPPSI-IV age bands). Bayley-3 cognitive scores were not significantly correlated with WPPSI-IV working memory composite scores. Maternal substance use did not significantly correlate with Bayley-3 or WPPSI-IV composite scores. Multiple linear regression analyses indicated that Bayley-3 cognitive composite scores significantly (p<.05) predicted WPPSI-IV verbal comprehension, visual spatial, and full-scale IQ composite scores, but did not significantly predict working memory composite scores.

Conclusions:

Taken together, results suggest that the Bayley-3 cognitive scale is a significant predictor of future verbal, visuospatial, and global cognitive scores during early childhood in children with suspected in-utero substance exposure. This research coincides with research in other pediatric populations (e.g., children born pre-term, non-clinical typically developing children). Implications, future directions, and study limitations are further explored.