INS NYC 2024 Program

Poster	Poster Session 10 Program Schedule 02/17/2024 09:00 am - 10:15 am Room: Shubert Complex (Posters 1-60) Poster Session 10: Neurodevelopmental \| Congenital Conditions Final Abstract #39 Maternal Thyroid Peroxidase Antibodies in Pregnancy and Child IQ Meaghan Hall, York University, Toronto, Canada Jonathan Chevrier, McGill University, Montreal, Canada Joanne Rovet, The Hospital for Sick Children, Toronto, Canada Bruce Lanphear, Simon Fraser University, Burnaby, Canada Christine Till, York University, Toronto, Canada Category: Prenatal/Perinatal Factors/Prematurity Keyword 1: intellectual functioning Keyword 2: prenatal factors Objective: Thyroid dysfunction in pregnant women has been linked with diminished intelligence abilities in their children. High concentrations of thyroid peroxidase antibody (TPOAb) are a risk factor for thyroid dysfunction, but few studies have examined the association between maternal antibodies to TPO and intellectual abilities in children. We investigated whether maternal antibodies to TPO in early pregnancy were associated with children’s intellectual abilities among Canadian mother-child dyads enrolled in the Maternal-Infant Research on Environmental Chemicals (MIREC) study. Participants and Methods: We measured TPOAb concentrations in 571 maternal plasma samples collected during the first trimester of pregnancy. Women were considered TPOAb-positive if their TPOAb levels were > 5.6 IU/mL. We assessed child Full-Scale IQ (FSIQ), Verbal IQ (VIQ), and Performance IQ (PIQ) at 3-4 years of age using the Wechsler Preschool and Primary Scale of Intelligence, 3^rd Edition. We used multiple linear regression to test the association between maternal TPOAb concentrations and child FSIQ, VIQ, and PIQ controlling for maternal age, race, level of education, smoking status, parity, child sex, quality of the home environment, and study site. Regression coefficients and respective 95% confidence intervals (CIs) were reported per 100 IU/mL (i.e., 10%) increase in TPOAb. Models were rerun using TPOAb status (i.e., < 5.6 IU/mL vs > 5.6 IU/mL) as the predictor. We also explored effect modification by child sex through inclusion of interaction terms. Results: Eighty-six (15.1%) of 571 women had TPOAb concentrations > 5.6 IU/mL. Median TPOAb concentrations were 0.45 (range= 0.11 – 905.03) IU/mL. A 100 IU/mL increase in maternal TPOAb was associated with a 1.32 decrease in child FSIQ (95% CI: -2.42, -0.22); TPOAb > 5.6 IU/mL was not significantly associated with child FSIQ scores (B= -1.15; 95% CI: -3.91, 1.61). Maternal TPOAb concentrations were also inversely associated with child VIQ, especially among boys (B= -2.51; 95% CI: -3.86, -1.16) (females: B= -0.13; 95% CI: -1.88, 1.62). Likewise, children born to women with TPOAb > 5.6 IU/mL had significantly lower VIQ than children born to those with TPOAb < 5.6 IU/mL (B= -2.81; 95% CI: -5.51, -0.11). In contrast, neither maternal TPOAb concentrations (B= -0.62; 95% CI: -1.87, 0.62) nor maternal TPOAb status (B= 0.92; 95% CI: -2.20, 4.04) were significantly associated with child PIQ. Conclusions: Higher concentrations of maternal antibody to thyroid peroxidase enzyme may adversely impact intellectual development of offspring, particularly among boys and for verbal IQ. Research to understand co-factors that interact with elevated TPOAb and place women and their infants at risk for thyroid dysfunction or cognitive deficits is needed.

Poster

02/17/2024
09:00 am - 10:15 am
Room: Shubert Complex (Posters 1-60)

Poster Session 10: Neurodevelopmental | Congenital Conditions

Final Abstract #39

Maternal Thyroid Peroxidase Antibodies in Pregnancy and Child IQ

Meaghan Hall, York University, Toronto, Canada
Jonathan Chevrier, McGill University, Montreal, Canada
Joanne Rovet, The Hospital for Sick Children, Toronto, Canada
Bruce Lanphear, Simon Fraser University, Burnaby, Canada
Christine Till, York University, Toronto, Canada

Category: Prenatal/Perinatal Factors/Prematurity

Keyword 1: intellectual functioning
Keyword 2: prenatal factors

Objective:

Thyroid dysfunction in pregnant women has been linked with diminished intelligence abilities in their children. High concentrations of thyroid peroxidase antibody (TPOAb) are a risk factor for thyroid dysfunction, but few studies have examined the association between maternal antibodies to TPO and intellectual abilities in children. We investigated whether maternal antibodies to TPO in early pregnancy were associated with children’s intellectual abilities among Canadian mother-child dyads enrolled in the Maternal-Infant Research on Environmental Chemicals (MIREC) study.

Participants and Methods:

We measured TPOAb concentrations in 571 maternal plasma samples collected during the first trimester of pregnancy. Women were considered TPOAb-positive if their TPOAb levels were > 5.6 IU/mL. We assessed child Full-Scale IQ (FSIQ), Verbal IQ (VIQ), and Performance IQ (PIQ) at 3-4 years of age using the Wechsler Preschool and Primary Scale of Intelligence, 3^rd Edition. We used multiple linear regression to test the association between maternal TPOAb concentrations and child FSIQ, VIQ, and PIQ controlling for maternal age, race, level of education, smoking status, parity, child sex, quality of the home environment, and study site. Regression coefficients and respective 95% confidence intervals (CIs) were reported per 100 IU/mL (i.e., 10%) increase in TPOAb. Models were rerun using TPOAb status (i.e., < 5.6 IU/mL vs > 5.6 IU/mL) as the predictor. We also explored effect modification by child sex through inclusion of interaction terms.

Results:

Eighty-six (15.1%) of 571 women had TPOAb concentrations > 5.6 IU/mL. Median TPOAb concentrations were 0.45 (range= 0.11 – 905.03) IU/mL. A 100 IU/mL increase in maternal TPOAb was associated with a 1.32 decrease in child FSIQ (95% CI: -2.42, -0.22); TPOAb > 5.6 IU/mL was not significantly associated with child FSIQ scores (B= -1.15; 95% CI: -3.91, 1.61). Maternal TPOAb concentrations were also inversely associated with child VIQ, especially among boys (B= -2.51; 95% CI: -3.86, -1.16) (females: B= -0.13; 95% CI: -1.88, 1.62). Likewise, children born to women with TPOAb > 5.6 IU/mL had significantly lower VIQ than children born to those with TPOAb < 5.6 IU/mL (B= -2.81; 95% CI: -5.51, -0.11). In contrast, neither maternal TPOAb concentrations (B= -0.62; 95% CI: -1.87, 0.62) nor maternal TPOAb status (B= 0.92; 95% CI: -2.20, 4.04) were significantly associated with child PIQ.

Conclusions:

Higher concentrations of maternal antibody to thyroid peroxidase enzyme may adversely impact intellectual development of offspring, particularly among boys and for verbal IQ. Research to understand co-factors that interact with elevated TPOAb and place women and their infants at risk for thyroid dysfunction or cognitive deficits is needed.