INS NYC 2024 Program

Poster	Poster Session 09 Program Schedule 02/16/2024 03:30 pm - 04:45 pm Room: Majestic Complex (Posters 61-120) Poster Session 09: Epilepsy \| Oncology \| MS \| Infectious Disease Final Abstract #97 Self- and Informant-Reported Everyday Executive Functioning After COVID-19 Riikka Pihlaja, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland Suvi Öhman, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland Henriikka Ollila, Helsinki University Hospital and University of Helsinki, Helsinki, Finland Annamari Tuulio-Henriksson, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland Sanna Koskinen, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland Marjaana Tiainen, Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland Viljami Salmela, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland Johanna Hästbacka, Department of Anesthesiology and Intensive Care, Tampere University Hospital and Tampere University, Tampere, Finland Laura Hokkanen, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland Category: Infectious Disease (HIV/COVID/Hepatitis/Viruses) Keyword 1: infectious disease Keyword 2: executive functions Keyword 3: self-report Objective: COVID-19 can lead to changes in cognitive functioning, with executive functioning being one the most common cognitive domains affected. Everyday executive functioning is relevant to managing daily and working life, but research related to COVID-19 is scarce. We examined self-reported everyday executive functioning and its associations with disease severity and informant-report in three COVID-19 severity groups: ICU-treated, ward-treated, and home-isolated. This study is part of the RECOVID-20 project (ClinicalTrials.gov Identifier NCT04864938). Participants and Methods: We assessed 111 COVID-19 patients (58.6% female, median age 57 (IQR 47-65)) who were treated at ICU (ICU; n=42) or other hospital wards (WARD; n=40) or isolated at home (HOME; n=29) and a non-COVID-19 control group (CONTROL; n= 43, 48.8% female, median age 56 (IQR 49-68)). Everyday executive functioning was assessed with the Behavior Rating Inventory of Executive Function-Adults (BRIEF-A) self-report and informant-report versions. The patients were evaluated at three and six months after COVID-19 and the controls once. The 75 items of BRIEF-A form an overall summary score, the Global Executive Composite (GEC), with higher scores indicating a higher incidence of difficulties. BRIEF-A raw scores were used in analysis. Group differences were analyzed with one-way ANOVA and the effects of group and time with two-way repeated measures ANOVA. Associations between self- and informant-reports were assessed with Pearson’s correlations. Results: At three months, mean self-reported GEC raw scores were 102.0 (SD 23.9) for the ICU group, 101.5 (22.4) for WARD, and 104.6 (24.1) for HOME group. At six months, the corresponding scores were: ICU: 105.2 (28.4), WARD: 97.7 (23.7), and HOME: 97.3 (20.1). The control group had a mean GEC of 98.7 (SD 18.4). There were no statistically significant differences in mean GEC scores between the COVID-19 groups and control group at three (F (3,153) = .422, p=.738, η²_p = .008) or six months (F (3,153) = 1.005, p=.393, η²_p = .020). Regarding temporal change in GEC scores, there was not a significant effect of time (F (1,108) = 2.795, p=.097, η²_p = .025) but a statistically significant interaction of measurement time and group (F (2,108) = 3.748, p=.027, η²_p = .065) was found. In the HOME group, GEC scores decreased from 3 to 6 months (p=.019). Correlations between BRIEF-A self-report and informant-report varied according to group. In the three-month evaluation, correlations between self- and informant-reports were strongest in the ICU (r=.847, p<.001) group and significant also in WARD (r=.529, p<.001) and CONTROL (r=.331, p=.030) groups but non-significant in the HOME (r=.242, p=.207) group. Conclusions: There were no significant differences in BRIEF-A raw scores between patients in three COVID-19 severity groups and a non-COVID control group. This suggests that everyday executive functioning seems not to be largely affected after COVID-19. Overall, the state of everyday executive functioning did not notably change in follow-up from three to six months. However, the mean GEC score decreased in follow-up in the HOME group, indicating an improvement in average self-evaluated everyday executive functioning. The highest correlations between self- and informant-evaluation were found in the ICU group.

Poster

02/16/2024
03:30 pm - 04:45 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 09: Epilepsy | Oncology | MS | Infectious Disease

Final Abstract #97

Self- and Informant-Reported Everyday Executive Functioning After COVID-19

Riikka Pihlaja, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Suvi Öhman, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Henriikka Ollila, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Annamari Tuulio-Henriksson, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Sanna Koskinen, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Marjaana Tiainen, Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Viljami Salmela, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Johanna Hästbacka, Department of Anesthesiology and Intensive Care, Tampere University Hospital and Tampere University, Tampere, Finland
Laura Hokkanen, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland

Category: Infectious Disease (HIV/COVID/Hepatitis/Viruses)

Keyword 1: infectious disease
Keyword 2: executive functions
Keyword 3: self-report

Objective:

COVID-19 can lead to changes in cognitive functioning, with executive functioning being one the most common cognitive domains affected. Everyday executive functioning is relevant to managing daily and working life, but research related to COVID-19 is scarce. We examined self-reported everyday executive functioning and its associations with disease severity and informant-report in three COVID-19 severity groups: ICU-treated, ward-treated, and home-isolated. This study is part of the RECOVID-20 project (ClinicalTrials.gov Identifier NCT04864938).

Participants and Methods:

We assessed 111 COVID-19 patients (58.6% female, median age 57 (IQR 47-65)) who were treated at ICU (ICU; n=42) or other hospital wards (WARD; n=40) or isolated at home (HOME; n=29) and a non-COVID-19 control group (CONTROL; n= 43, 48.8% female, median age 56 (IQR 49-68)). Everyday executive functioning was assessed with the Behavior Rating Inventory of Executive Function-Adults (BRIEF-A) self-report and informant-report versions. The patients were evaluated at three and six months after COVID-19 and the controls once. The 75 items of BRIEF-A form an overall summary score, the Global Executive Composite (GEC), with higher scores indicating a higher incidence of difficulties. BRIEF-A raw scores were used in analysis. Group differences were analyzed with one-way ANOVA and the effects of group and time with two-way repeated measures ANOVA. Associations between self- and informant-reports were assessed with Pearson’s correlations.

Results:

At three months, mean self-reported GEC raw scores were 102.0 (SD 23.9) for the ICU group, 101.5 (22.4) for WARD, and 104.6 (24.1) for HOME group. At six months, the corresponding scores were: ICU: 105.2 (28.4), WARD: 97.7 (23.7), and HOME: 97.3 (20.1). The control group had a mean GEC of 98.7 (SD 18.4). There were no statistically significant differences in mean GEC scores between the COVID-19 groups and control group at three (F (3,153) = .422, p=.738, η²_p = .008) or six months (F (3,153) = 1.005, p=.393, η²_p = .020). Regarding temporal change in GEC scores, there was not a significant effect of time (F (1,108) = 2.795, p=.097, η²_p = .025) but a statistically significant interaction of measurement time and group (F (2,108) = 3.748, p=.027, η²_p = .065) was found. In the HOME group, GEC scores decreased from 3 to 6 months (p=.019). Correlations between BRIEF-A self-report and informant-report varied according to group. In the three-month evaluation, correlations between self- and informant-reports were strongest in the ICU (r=.847, p<.001) group and significant also in WARD (r=.529, p<.001) and CONTROL (r=.331, p=.030) groups but non-significant in the HOME (r=.242, p=.207) group.

Conclusions:

There were no significant differences in BRIEF-A raw scores between patients in three COVID-19 severity groups and a non-COVID control group. This suggests that everyday executive functioning seems not to be largely affected after COVID-19. Overall, the state of everyday executive functioning did not notably change in follow-up from three to six months. However, the mean GEC score decreased in follow-up in the HOME group, indicating an improvement in average self-evaluated everyday executive functioning. The highest correlations between self- and informant-evaluation were found in the ICU group.