INS NYC 2024 Program

Poster	Poster Session 09 Program Schedule 02/16/2024 03:30 pm - 04:45 pm Room: Majestic Complex (Posters 61-120) Poster Session 09: Epilepsy \| Oncology \| MS \| Infectious Disease Final Abstract #81 Using Mood to Predict Postsurgical Memory Change in Epilepsy Patients Chantal Müller-Cohn, Alliant International University, San Diego, United States Alexis Ambeau, Ball State University, Muncie, United States Mark Buckman, University of Kansas, Lawrence, United States Carrie McDonald, University of California, San Diego, San Diego, United States Marc Norman, University of California, San Diego, San Diego, United States Liana Abascal, Alliant International University, San Diego, United States Amanda Gooding, University of California, San Diego, San Diego, United States Category: Epilepsy/Seizures Keyword 1: neuropsychological assessment Keyword 2: depression Objective: Neuropsychological assessments are essential for clinical decision-making in surgical treatment of refractory temporal lobe epilepsy (TLE). Assessments have the potential to predict risk for cognitive decline following surgery. To date one study has determined depressed mood to also be a statistically significant predictor of memory decline using the Wechsler Memory Scale-III (Busch et al., 2011). To further understand the relationship between mood, memory, and TLE, this study aimed to identify whether presurgical depressed mood (dichotomized by BDI-II >11; Doherty et al., 2021) could predict postsurgical memory change using commonly used neuropsychological measures. We hypothesized that presurgical depressed mood would predict poorer postsurgical memory outcomes. Participants and Methods: We used archival clinical data from 62 adult surgical patients (self-reported, 61% white, 21% more than one race, 8% Black/African American, 6% Asian; 13% Hispanic ethnicity; average age = 34 [SD = 11.95]) with medically intractable TLE (left = 30; right = 32) who received temporal lobe resections. Participants exhibiting depressed mood (n = 32) and nondepressed mood (n = 30) were examined before and after surgery. From the sample, 60 participants had pre and post California Verbal Learning Test-Second Edition (CVLT-II), Long Delay Free Recall, data and 48 participants had pre and post Brief Visual Motor Test-Revised (BVMT-R), Visual Delayed Recall data. We conducted hierarchical regressions to assess whether dichotomized presurgical mood state (i.e., depressed mood, non-depressed mood) accounted for greater variance in memory change than presurgical memory scores alone. We also conducted paired samples t-tests to determine whether an increase in depressive symptoms following surgery may have occurred, which could account for declines in memory. Results: Mood was not a predictor of verbal or visual memory change in right surgical patients. In contrast, mood was a significant predictor of visual memory (B = -12.738, p = .007) and verbal memory (B = -10.792, p = .031) change in left surgical patients. Additionally, in left-sided surgeries, mood accounted for greater variance in memory change than presurgical memory scores in both visual memory (F change [1, 20] = 8.859; p < .007; R2 change = .272) and verbal memory (F change [1, 26] = 5.222; p < .031; R2 change = .088). Paired samples t-tests were not significant for differences between pre-surgical and post-surgical mood scores. Similar to results by Busch and colleagues (2011), results suggest that depressed mood serves as a predictor of memory change only among left-TLE patients within this sample. Specifically, left-TLE patients with poor mood were predicted to have statistically significantly lower change scores, suggesting these patients improved less or declined more in memory outcomes than non-depressed left-TLE patients. Conclusions: This study highlights the importance of mood in presurgical epilepsy evaluations and its utility in informing presurgical treatments in left-TLE. Results suggest that elevated pre-surgical depressive symptomatology is a risk factor for poorer post-surgical outcomes in left-TLE surgery. Mood should therefore be considered when counseling patients about cognitive risks associated with TLE surgery.

Poster

02/16/2024
03:30 pm - 04:45 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 09: Epilepsy | Oncology | MS | Infectious Disease

Final Abstract #81

Using Mood to Predict Postsurgical Memory Change in Epilepsy Patients

Chantal Müller-Cohn, Alliant International University, San Diego, United States
Alexis Ambeau, Ball State University, Muncie, United States
Mark Buckman, University of Kansas, Lawrence, United States
Carrie McDonald, University of California, San Diego, San Diego, United States
Marc Norman, University of California, San Diego, San Diego, United States
Liana Abascal, Alliant International University, San Diego, United States
Amanda Gooding, University of California, San Diego, San Diego, United States

Category: Epilepsy/Seizures

Keyword 1: neuropsychological assessment
Keyword 2: depression

Objective:

Neuropsychological assessments are essential for clinical decision-making in surgical treatment of refractory temporal lobe epilepsy (TLE). Assessments have the potential to predict risk for cognitive decline following surgery. To date one study has determined depressed mood to also be a statistically significant predictor of memory decline using the Wechsler Memory Scale-III (Busch et al., 2011). To further understand the relationship between mood, memory, and TLE, this study aimed to identify whether presurgical depressed mood (dichotomized by BDI-II >11; Doherty et al., 2021) could predict postsurgical memory change using commonly used neuropsychological measures. We hypothesized that presurgical depressed mood would predict poorer postsurgical memory outcomes.

Participants and Methods:

We used archival clinical data from 62 adult surgical patients (self-reported, 61% white, 21% more than one race, 8% Black/African American, 6% Asian; 13% Hispanic ethnicity; average age = 34 [SD = 11.95]) with medically intractable TLE (left = 30; right = 32) who received temporal lobe resections. Participants exhibiting depressed mood (n = 32) and nondepressed mood (n = 30) were examined before and after surgery. From the sample, 60 participants had pre and post California Verbal Learning Test-Second Edition (CVLT-II), Long Delay Free Recall, data and 48 participants had pre and post Brief Visual Motor Test-Revised (BVMT-R), Visual Delayed Recall data.

We conducted hierarchical regressions to assess whether dichotomized presurgical mood state (i.e., depressed mood, non-depressed mood) accounted for greater variance in memory change than presurgical memory scores alone. We also conducted paired samples t-tests to determine whether an increase in depressive symptoms following surgery may have occurred, which could account for declines in memory.

Results:

Mood was not a predictor of verbal or visual memory change in right surgical patients. In contrast, mood was a significant predictor of visual memory (B = -12.738, p = .007) and verbal memory (B = -10.792, p = .031) change in left surgical patients. Additionally, in left-sided surgeries, mood accounted for greater variance in memory change than presurgical memory scores in both visual memory (F change [1, 20] = 8.859; p < .007; R2 change = .272) and verbal memory (F change [1, 26] = 5.222; p < .031; R2 change = .088). Paired samples t-tests were not significant for differences between pre-surgical and post-surgical mood scores.

Similar to results by Busch and colleagues (2011), results suggest that depressed mood serves as a predictor of memory change only among left-TLE patients within this sample. Specifically, left-TLE patients with poor mood were predicted to have statistically significantly lower change scores, suggesting these patients improved less or declined more in memory outcomes than non-depressed left-TLE patients.

Conclusions:

This study highlights the importance of mood in presurgical epilepsy evaluations and its utility in informing presurgical treatments in left-TLE. Results suggest that elevated pre-surgical depressive symptomatology is a risk factor for poorer post-surgical outcomes in left-TLE surgery. Mood should therefore be considered when counseling patients about cognitive risks associated with TLE surgery.