INS NYC 2024 Program

Poster	Poster Session 09 Program Schedule 02/16/2024 03:30 pm - 04:45 pm Room: Majestic Complex (Posters 61-120) Poster Session 09: Epilepsy \| Oncology \| MS \| Infectious Disease Final Abstract #66 Within-visit Blood Pressure Variability and Cognitive Performance in Middle-Aged Adults with Metabolic Risks Yanrong Li, Department of Psychology, The University of Texas at Austin, Austin, United States Tianyu Wang, Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, United States Marie Caillaud, Department of Psychology, The University of Texas at Austin, Austin, United States Cherry Youn, Department of Psychology, The University of Texas at Austin, Austin, United States Isabelle Gallagher, Department of Psychology, The University of Texas at Austin, Austin, United States Hirofumi Tanaka, Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, United States Andreana Haley, Department of Psychology, The University of Texas at Austin, Austin, United States Category: Medical/Neurological Disorders/Other (Adult) Keyword 1: hypertension Keyword 2: apolipoprotein E Keyword 3: vascular cognitive impairment Objective: Blood pressure variability (BPV) indices have been shown to be negatively associated with cognitive function. Yet, few studies presented contradictory results, showing a positive relationship between cognition and within-visit BPV, a short-term low frequency BPV index. In effort to understand the heterogeneity within BPV indices, and to demonstrate the clinical relevance of within-visit BPV, this study investigated the relationship between within-visit BPV and cognitive function in middle-aged adults with Metabolic Syndrome (MetS). Participants and Methods: A total of 191 middle-aged adults (ages 40 to 60), free of clinical conditions but exhibiting metabolic vulnerabilities were enrolled. They underwent a comprehensive neuropsychological assessment evaluating executive function (Stroop Color-Word, Digit Span-Backward, Trail Making-B, and Controlled Oral Word Association Test), memory (California Verbal Learning Test II short- and long-delay free recall), and attention (Trail Making-A, Digit Span-Forward, Stroop-Color, and Stroop-Word), as well as cardiometabolic measurements. Within-visit BPV was calculated from 3 supine BP measurements captured over a 10 to 15-minute interval. Multiple regression was employed to predict cognitive performance based on BPV with different covariates, including model 1 (age, sex, education, mean BP), model 2 (model 1 + whether participant met criteria for each of MetS’s conditions), and model 3 (model 1 + physical activity, hypertension medication, waist circumference, triglyceride, HDL, glucose). Lastly, the study introduced Apolipoprotein E4 (APOE4) carrier status into model 3 as a moderator. Results: BPV was associated with better executive function performance (model 1: F(5, 185) = 3.231, R² = 0.080, P = .008; β_BPV = .195, P = .037) but not memory or attention. The same relationship held after controlling for metabolic risks in model 2 (F(11, 135) = 1.995, R² = 0.140, P = .033; β_BPV = .270, P = .018)and model 3 (F(11, 125) = 3.172, R² = 0.218, P = .0008; β_BPV = .251, P = .019). Although the moderation effect of APOE4 status on BPV-cognition relationship was not significant, higher BPV consistently trended with worse performance in executive function (β = -.338, P = .460), attention (β = -.230, P = .636), and memory (β = -.638, P = .247) only in APOE4 carriers. Conclusions: In marked contrast to literature on longer-term BPVs, we found a positive association between within-visit BPV and cognitive performance in middle-aged adults with cardiometabolic risk. While longer-term BPVs are potentially linked to or may contribute to adverse physiological and cerebral events, within-visit BPV may reflect a healthy autoregulatory function of the autonomic nervous system, maintaining constant BP in middle-age. Furthermore, though the interaction was not significant, within-visit BPV was negatively associated with cognitive performance in APOE4 carriers, suggesting that carriers might possess predisposed vulnerability (i.e., leaky blood brain barrier) that makes them susceptible to influence of BP fluctuations. In conclusion, within-visit BPV based on as little as 3 BP measurements provides valuable clinical information and may be a promising measure in clinical and research settings. Further research is imperative to better understand the complex BPV and cognition relationship, explore underlying mechanisms, identify population at risk, and discuss the necessity for intervention.

Poster

02/16/2024
03:30 pm - 04:45 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 09: Epilepsy | Oncology | MS | Infectious Disease

Final Abstract #66

Within-visit Blood Pressure Variability and Cognitive Performance in Middle-Aged Adults with Metabolic Risks

Yanrong Li, Department of Psychology, The University of Texas at Austin, Austin, United States
Tianyu Wang, Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, United States
Marie Caillaud, Department of Psychology, The University of Texas at Austin, Austin, United States
Cherry Youn, Department of Psychology, The University of Texas at Austin, Austin, United States
Isabelle Gallagher, Department of Psychology, The University of Texas at Austin, Austin, United States
Hirofumi Tanaka, Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, United States
Andreana Haley, Department of Psychology, The University of Texas at Austin, Austin, United States

Category: Medical/Neurological Disorders/Other (Adult)

Keyword 1: hypertension
Keyword 2: apolipoprotein E
Keyword 3: vascular cognitive impairment

Objective:

Blood pressure variability (BPV) indices have been shown to be negatively associated with cognitive function. Yet, few studies presented contradictory results, showing a positive relationship between cognition and within-visit BPV, a short-term low frequency BPV index. In effort to understand the heterogeneity within BPV indices, and to demonstrate the clinical relevance of within-visit BPV, this study investigated the relationship between within-visit BPV and cognitive function in middle-aged adults with Metabolic Syndrome (MetS).

Participants and Methods:

A total of 191 middle-aged adults (ages 40 to 60), free of clinical conditions but exhibiting metabolic vulnerabilities were enrolled. They underwent a comprehensive neuropsychological assessment evaluating executive function (Stroop Color-Word, Digit Span-Backward, Trail Making-B, and Controlled Oral Word Association Test), memory (California Verbal Learning Test II short- and long-delay free recall), and attention (Trail Making-A, Digit Span-Forward, Stroop-Color, and Stroop-Word), as well as cardiometabolic measurements. Within-visit BPV was calculated from 3 supine BP measurements captured over a 10 to 15-minute interval. Multiple regression was employed to predict cognitive performance based on BPV with different covariates, including model 1 (age, sex, education, mean BP), model 2 (model 1 + whether participant met criteria for each of MetS’s conditions), and model 3 (model 1 + physical activity, hypertension medication, waist circumference, triglyceride, HDL, glucose). Lastly, the study introduced Apolipoprotein E4 (APOE4) carrier status into model 3 as a moderator.

Results:

BPV was associated with better executive function performance (model 1: F(5, 185) = 3.231, R² = 0.080, P = .008; β_BPV = .195, P = .037) but not memory or attention. The same relationship held after controlling for metabolic risks in model 2 (F(11, 135) = 1.995, R² = 0.140, P = .033; β_BPV = .270, P = .018)and model 3 (F(11, 125) = 3.172, R² = 0.218, P = .0008; β_BPV = .251, P = .019). Although the moderation effect of APOE4 status on BPV-cognition relationship was not significant, higher BPV consistently trended with worse performance in executive function (β = -.338, P = .460), attention (β = -.230, P = .636), and memory (β = -.638, P = .247) only in APOE4 carriers.

Conclusions:

In marked contrast to literature on longer-term BPVs, we found a positive association between within-visit BPV and cognitive performance in middle-aged adults with cardiometabolic risk. While longer-term BPVs are potentially linked to or may contribute to adverse physiological and cerebral events, within-visit BPV may reflect a healthy autoregulatory function of the autonomic nervous system, maintaining constant BP in middle-age. Furthermore, though the interaction was not significant, within-visit BPV was negatively associated with cognitive performance in APOE4 carriers, suggesting that carriers might possess predisposed vulnerability (i.e., leaky blood brain barrier) that makes them susceptible to influence of BP fluctuations. In conclusion, within-visit BPV based on as little as 3 BP measurements provides valuable clinical information and may be a promising measure in clinical and research settings. Further research is imperative to better understand the complex BPV and cognition relationship, explore underlying mechanisms, identify population at risk, and discuss the necessity for intervention.