INS NYC 2024 Program

Poster	Poster Session 09 Program Schedule 02/16/2024 03:30 pm - 04:45 pm Room: Majestic Complex (Posters 61-120) Poster Session 09: Epilepsy \| Oncology \| MS \| Infectious Disease Final Abstract #65 The Application of the Community Mental Statis Examination (CMSE) to the non-CNS Cancer Population in Taiwan: evidence from pre-chemotherapy Colorectal cancer patients Chieh Ning Li, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University., Tainan, Taiwan Nai-Wen Guo, Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Taiwan, Taiwan Cheng-Yao Lin, Division of Hematology-Oncology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan Category: Cancer Keyword 1: neuropsychological assessment Keyword 2: cancer Keyword 3: neuro-oncology Objective: Evidence has shown that patients with non-central nervous system (non-CNS) cancers may experience neurocognitive symptoms before chemotherapy. The Community Mental Status Examination (CMSE) is a neurocognitive screening test developed in Taiwan that has been validated for patients with stroke and traumatic brain injury (TBI). Still, it has not yet been applied to non-CNS cancer patients. This study aims to present our initial findings from subjects with colorectal cancer before chemotherapy. Participants and Methods: Thirty participants (M=12, F=18) diagnosed with stage II or III colorectal cancer were recruited at a regional hospital in southern Taiwan. Each participant would be collected for CMSE, MMSE-C, and the Comprehensive Nonverbal Attention Test (CNAT) before undergoing chemotherapy. The total score and the four individual scale scores of CMSE, which encompass anterior, posterior, verbal, and non-verbal aspects, were calculated. Non-parametric analysis and Cronbach's alpha were employed to assess the sample's appropriateness. As indicators of criterion validity, MMSE-C and three tasks of CNAT were employed. Results: Age and education years exhibited a wide range of variation within the dataset, the mean age was 58.27±9.77 (min=37, max=73) while the mean education years were 11.97±3.49 (min=6, max=18). Non-parametric analysis revealed statistical significance when dividing groups based on age. Although no significant differences were observed when grouping by years of education, some distinctions still became apparent among the various groups. The Cronbach's alpha values were as follows: 0.915 for the total score in relation to the scale scores, 0.67 for the total score with each individual item, 0.667, 0.637, 0.617, and 0.675 for the four scale scores with their corresponding items, respectively. In comparison to MMSE-C, the results indicate that all 29 participants scored above the cutoff in MMSE-C, whereas 65.52% exhibited signs of neurocognitive impairment. Regarding the correlation between CMSE and CNAT, six out of the twelve CNAT indices exhibited a significant relationship with the non-verbal scale score. Additionally, all four indices in the focus attention tasks displayed a significant correlation with the posterior scale score, while impulsive errors in all three CNAT tasks showed a significant relationship with the anterior scale score. Conclusions: Preliminary data suggests that CMSE has the potential to serve as an effective screening test for pre-chemotherapy colorectal cancer patients. It has the ability to not only identify patients with neurocognitive impairments who might be overlooked by MMSE-C but also demonstrates good sensitivity to patients' non-verbal attention functioning.

Poster

02/16/2024
03:30 pm - 04:45 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 09: Epilepsy | Oncology | MS | Infectious Disease

Final Abstract #65

The Application of the Community Mental Statis Examination (CMSE) to the non-CNS Cancer Population in Taiwan: evidence from pre-chemotherapy Colorectal cancer patients

Chieh Ning Li, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University., Tainan, Taiwan
Nai-Wen Guo, Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Taiwan, Taiwan
Cheng-Yao Lin, Division of Hematology-Oncology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan

Category: Cancer

Keyword 1: neuropsychological assessment
Keyword 2: cancer
Keyword 3: neuro-oncology

Objective:

Evidence has shown that patients with non-central nervous system (non-CNS) cancers may experience neurocognitive symptoms before chemotherapy. The Community Mental Status Examination (CMSE) is a neurocognitive screening test developed in Taiwan that has been validated for patients with stroke and traumatic brain injury (TBI). Still, it has not yet been applied to non-CNS cancer patients. This study aims to present our initial findings from subjects with colorectal cancer before chemotherapy.

Participants and Methods:

Thirty participants (M=12, F=18) diagnosed with stage II or III colorectal cancer were recruited at a regional hospital in southern Taiwan. Each participant would be collected for CMSE, MMSE-C, and the Comprehensive Nonverbal Attention Test (CNAT) before undergoing chemotherapy. The total score and the four individual scale scores of CMSE, which encompass anterior, posterior, verbal, and non-verbal aspects, were calculated. Non-parametric analysis and Cronbach's alpha were employed to assess the sample's appropriateness. As indicators of criterion validity, MMSE-C and three tasks of CNAT were employed.

Results:

Age and education years exhibited a wide range of variation within the dataset, the mean age was 58.27±9.77 (min=37, max=73) while the mean education years were 11.97±3.49 (min=6, max=18). Non-parametric analysis revealed statistical significance when dividing groups based on age. Although no significant differences were observed when grouping by years of education, some distinctions still became apparent among the various groups. The Cronbach's alpha values were as follows: 0.915 for the total score in relation to the scale scores, 0.67 for the total score with each individual item, 0.667, 0.637, 0.617, and 0.675 for the four scale scores with their corresponding items, respectively. In comparison to MMSE-C, the results indicate that all 29 participants scored above the cutoff in MMSE-C, whereas 65.52% exhibited signs of neurocognitive impairment. Regarding the correlation between CMSE and CNAT, six out of the twelve CNAT indices exhibited a significant relationship with the non-verbal scale score. Additionally, all four indices in the focus attention tasks displayed a significant correlation with the posterior scale score, while impulsive errors in all three CNAT tasks showed a significant relationship with the anterior scale score.

Conclusions:

Preliminary data suggests that CMSE has the potential to serve as an effective screening test for pre-chemotherapy colorectal cancer patients. It has the ability to not only identify patients with neurocognitive impairments who might be overlooked by MMSE-C but also demonstrates good sensitivity to patients' non-verbal attention functioning.