| Poster | Poster Session 09 Program Schedule
02/16/2024
03:30 pm - 04:45 pm
Room: Shubert Complex (Posters 1-60)
Poster Session 09: Epilepsy | Oncology | MS | Infectious Disease
Final Abstract #58
Low-Grade Gliomas surgery in Latin America: The role of awake surgery in preserving cognitive and quality of life integrity.
Greta Keller, Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina
Nicolas Corvalan, Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina
Agostina Carello, Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina
Vanina Banjsak, Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina
Noelia Egido, Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina
Guido Caffaratti, Department of Neurosurgery, Fleni, Buenos Aires, Argentina
Ricardo Allegri, Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina
Andres Cervio, Department of Neurosurgery, Fleni, Buenos Aires, Argentina
Lucia Crivelli, Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina
Category: Medical/Neurological Disorders/Other (Adult)
Keyword 1: brain tumor
Keyword 2: cognitive control
Objective:
Low-grade gliomas (LGG) are a heterogeneous group of brain tumors that have historically been considered benign. The goal of awake craniotomy is to remove as much of the diseased cells/tumor as possible without compromising the critical cognitive functions and functions that may be critical to the patient's overall functioning. In this context, the assessment of cognitive performance could help to ensure the preservation of the patient's existing level of functionality. The aim of this study is to characterize and compare quality of life, cognitive outcomes and neuropsychiatric measures in patients with heterogeneous LGG before and after surgery.
Participants and Methods:
We conducted a study involving eleven patients diagnosed with LGG who underwent awake surgery. During the intraoperative phase we administered a battery of cognitive tasks, including the following: naming task (Boston 60), reading of regular and irregular words and verbal naming task (UDS-APP) and, automatic serial, sentence completion, spelling recognition, auditory verbal discrimination, repetition and command comprehension tasks (WAB). All participants underwent a comprehensive pre- and post-operative neuropsychological assessment that evaluated diverse aspects such as memory, language, attention, executive functions, visuospatial abilities, social cognition, praxis, agnosias, functionality, mood, and quality of life. We evaluated normality and homoscedasticity and used repeated measures analysis of variance or Kruskal-Wallis tests to examine changes in cognitive, functional and neuropsychiatric measures.
Results:
The participants had an average age of 37 with a range of 25-65 years old and an average education level of 15.1 (±2.1) years. Among them, 72.7% (8) were male. On average, the cognitive exam were conducted 6.6 (±2.7) months after surgery. Notably, a significant improvement change was observed in the re-evaluation of quality of life after surgery (F(1,19)=14.96, p=0.001). No significant effects were observed in memory (F(1,19)=0.012, p=0.914), attention (F(1,19)=0.181, p=0.675), social cognition (F(1,19)=2.82, p= 0.14) nor language (F(1,19)=0.178, p=0.678), suggesting cognitive functioning similar to pre-surgery.
Conclusions:
Our findings suggest that awake surgery could be a viable option for LGG resection, allowing for the preservation of cognitive function. This study reveals significant improvements in quality of life measures among patients undergoing this technique, supporting its benefits in tumor recession. Looking ahead, we aim to expand our sample size and continue conducting a longitudinal study on these patients to track their long-term progress and outcomes.
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