INS NYC 2024 Program

Poster	Poster Session 09 Program Schedule 02/16/2024 03:30 pm - 04:45 pm Room: Shubert Complex (Posters 1-60) Poster Session 09: Epilepsy \| Oncology \| MS \| Infectious Disease Final Abstract #47 Identi-Fi Performance in a Clinical Sample of People with Epilepsy Jared Hammond, Dartmouth-Hitchcock Medical Center, Lebanon, United States Robert Roth, Dartmouth-Hitchcock Medical Center, Lebanon, United States Grant Moncrief, Dartmouth-Hitchcock Medical Center, Lebanon, United States Nahal Heydari, Dartmouth-Hitchcock Medical Center, Lebanon, United States Anna Graefe, Dartmouth-Hitchcock Medical Center, Lebanon, United States Category: Epilepsy/Seizures Keyword 1: epilepsy / seizure disorders Keyword 2: assessment Keyword 3: visuospatial functions Objective: People with epilepsy (PWE) commonly have cognitive difficulties, including visuospatial functioning. The Identi-Fi (IDFI) is a new test of visuospatial organization with visual recognition (VR) and visual matching (VM) subtests, as well as an overall summary score (VOI). To our knowledge, no prior study has evaluated performance on this measure in PWE. We aimed to characterize IDFI performance in a clinical sample of PWE and understand its association with other neuropsychological tests. Participants and Methods: Participants included 48 PWE (focal=72.9%, generalized=27.1%, 50.0% female; M_age=50.10 years, SD=17.61, range=19-76; M_education=14.29 years, SD=2.66, range=8-20; right-handed=95.8%; white=95.8%). On average, they were taking 2.04 anti-seizure medications (SD=1.16, range=0-5) and about half (56.3%) had well-controlled seizures. None had prior epilepsy neurosurgery. Participants completed comprehensive clinical neuropsychological evaluation at a large Northeastern academic medical center, including Animal Fluency, Boston Naming Test (BNT), Brief Visuospatial Memory Test-Revised (BVMT-R), Controlled Oral Word Association Test, Rey Complex Figure and Recognition Test (RCFT), Trail Making Test (TMT), and WAIS-IV Vocabulary and Block Design. Data were analyzed using correlations (Spearman’s rho), T-tests, and ANOVAs. Correlation sample sizes ranged from 34 to 48 given participants were not administered all tests. Impaired IDFI performance was defined by AACN guidelines (Guilmette et al., 2020) with T<30 for VR/VM and SS<70 for VOI. Results: Mean age-corrected scores for IDFI ranged from low average to average, specifically VR_T=42.25 (SD=10.73), VM_T=44.71 (SD=11.81), and VOI_SS=88.58 (SD=17.15) with consistent impairment rates (VR=14.6%, VM=14.6%, VOI=10.4%). Subtest-level patterns of performance were generally intact for both conditions (79.2%), with 6.3% impaired on VR only, 6.3% impaired on VM only, and 8.3% impaired for both conditions. VOI significantly correlated with BVMT-R Total Recall (r_s=.391, p=.010), BVMT-R Delayed Recall (r_s=.345, p=.025), TMT-A (r_s=.341, p=.019), and TMT-B (r_s=.318, p=.033), approaching significance for WAIS-IV Block Design (r_s=.316, p=.053). As VR was not significantly correlated with any measure, VM appeared mainly responsible, with relationships noted with WAIS-IV Vocabulary (r_s=.389, p=.008) and Block Design (r_s=.394, p=.014), BVMT-R Delayed Recall (r_s=.326, p=.035), TMT-A (r_s=.393, p=.006), and TMT-B (r_s=.449, p=.002). No IDFI score was related to BNT, verbal fluency, RCFT approach (organized vs. not organized), education, or sex, but VM was correlated with age (r_s=.384, p=.007). IDFI scores were not associated with epilepsy type or hemisphere of seizure onset. Conclusions: PWE on average scored slightly below the normative IDFI sample, and less than 10% were impaired on either or both subtests. Importantly, IDFI performance was related to processing speed, cognitive flexibility, and visuoconstruction, similar to the Hooper Visual Organization Test. However, IDFI’s relationship with learning, memory, and vocabulary, but lack of relationship with confrontation naming and phonemic fluency, has not been previously described. Furthermore, many of the associations between the VOI and other tests were driven by VM. Thus, while the IDFI test manual emphasizes VOI over subtests, given higher reliability, our findings indicate that, in PWE, associations with other cognitive tests differ between two subtests. While these conclusions should be interpreted cautiously given small sample size and demographic limitations (i.e., homogeneous race/ethnicity), findings suggest promising utility of the IDFI in epilepsy.

Poster

02/16/2024
03:30 pm - 04:45 pm
Room: Shubert Complex (Posters 1-60)

Poster Session 09: Epilepsy | Oncology | MS | Infectious Disease

Final Abstract #47

Identi-Fi Performance in a Clinical Sample of People with Epilepsy

Jared Hammond, Dartmouth-Hitchcock Medical Center, Lebanon, United States
Robert Roth, Dartmouth-Hitchcock Medical Center, Lebanon, United States
Grant Moncrief, Dartmouth-Hitchcock Medical Center, Lebanon, United States
Nahal Heydari, Dartmouth-Hitchcock Medical Center, Lebanon, United States
Anna Graefe, Dartmouth-Hitchcock Medical Center, Lebanon, United States

Category: Epilepsy/Seizures

Keyword 1: epilepsy / seizure disorders
Keyword 2: assessment
Keyword 3: visuospatial functions

Objective:

People with epilepsy (PWE) commonly have cognitive difficulties, including visuospatial functioning. The Identi-Fi (IDFI) is a new test of visuospatial organization with visual recognition (VR) and visual matching (VM) subtests, as well as an overall summary score (VOI). To our knowledge, no prior study has evaluated performance on this measure in PWE. We aimed to characterize IDFI performance in a clinical sample of PWE and understand its association with other neuropsychological tests.

Participants and Methods:

Participants included 48 PWE (focal=72.9%, generalized=27.1%, 50.0% female; M_age=50.10 years, SD=17.61, range=19-76; M_education=14.29 years, SD=2.66, range=8-20; right-handed=95.8%; white=95.8%). On average, they were taking 2.04 anti-seizure medications (SD=1.16, range=0-5) and about half (56.3%) had well-controlled seizures. None had prior epilepsy neurosurgery. Participants completed comprehensive clinical neuropsychological evaluation at a large Northeastern academic medical center, including Animal Fluency, Boston Naming Test (BNT), Brief Visuospatial Memory Test-Revised (BVMT-R), Controlled Oral Word Association Test, Rey Complex Figure and Recognition Test (RCFT), Trail Making Test (TMT), and WAIS-IV Vocabulary and Block Design. Data were analyzed using correlations (Spearman’s rho), T-tests, and ANOVAs. Correlation sample sizes ranged from 34 to 48 given participants were not administered all tests. Impaired IDFI performance was defined by AACN guidelines (Guilmette et al., 2020) with T<30 for VR/VM and SS<70 for VOI.

Results:

Mean age-corrected scores for IDFI ranged from low average to average, specifically VR_T=42.25 (SD=10.73), VM_T=44.71 (SD=11.81), and VOI_SS=88.58 (SD=17.15) with consistent impairment rates (VR=14.6%, VM=14.6%, VOI=10.4%). Subtest-level patterns of performance were generally intact for both conditions (79.2%), with 6.3% impaired on VR only, 6.3% impaired on VM only, and 8.3% impaired for both conditions. VOI significantly correlated with BVMT-R Total Recall (r_s=.391, p=.010), BVMT-R Delayed Recall (r_s=.345, p=.025), TMT-A (r_s=.341, p=.019), and TMT-B (r_s=.318, p=.033), approaching significance for WAIS-IV Block Design (r_s=.316, p=.053). As VR was not significantly correlated with any measure, VM appeared mainly responsible, with relationships noted with WAIS-IV Vocabulary (r_s=.389, p=.008) and Block Design (r_s=.394, p=.014), BVMT-R Delayed Recall (r_s=.326, p=.035), TMT-A (r_s=.393, p=.006), and TMT-B (r_s=.449, p=.002). No IDFI score was related to BNT, verbal fluency, RCFT approach (organized vs. not organized), education, or sex, but VM was correlated with age (r_s=.384, p=.007). IDFI scores were not associated with epilepsy type or hemisphere of seizure onset.

Conclusions:

PWE on average scored slightly below the normative IDFI sample, and less than 10% were impaired on either or both subtests. Importantly, IDFI performance was related to processing speed, cognitive flexibility, and visuoconstruction, similar to the Hooper Visual Organization Test. However, IDFI’s relationship with learning, memory, and vocabulary, but lack of relationship with confrontation naming and phonemic fluency, has not been previously described. Furthermore, many of the associations between the VOI and other tests were driven by VM. Thus, while the IDFI test manual emphasizes VOI over subtests, given higher reliability, our findings indicate that, in PWE, associations with other cognitive tests differ between two subtests. While these conclusions should be interpreted cautiously given small sample size and demographic limitations (i.e., homogeneous race/ethnicity), findings suggest promising utility of the IDFI in epilepsy.