INS NYC 2024 Program

Poster	Poster Session 09 Program Schedule 02/16/2024 03:30 pm - 04:45 pm Room: Shubert Complex (Posters 1-60) Poster Session 09: Epilepsy \| Oncology \| MS \| Infectious Disease Final Abstract #45 Longitudinal Neuropsychological Profiles of Post COVID-19 Condition: Reassessing Individuals with Initial Cognitive Complaints in a 1-Year Follow-Up Study Nicholas Grunden, Concordia University, Montreal, Canada Marco Calabria, Universitat Oberta de Catalunya, Barcelona, Spain Carmen García-Sánchez, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Catalina Pons, Blanquerna, Universitat Ramon Llull, Barcelona, Spain Juan Antonio Arroyo, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Beatriz Gómez-Anson, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain María del Carmen Estévez-García, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Roberto Belvís, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Noemí Morollón, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Mónica Cordero-Carcedo, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Isabel Mur, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Virginia Pomar, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Pere Domingo, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Category: Infectious Disease (HIV/COVID/Hepatitis/Viruses) Keyword 1: infectious disease Keyword 2: cognitive course Objective: Cognitive difficulties are reported as lasting sequelae within post COVID-19 condition. However, the chronicity of these difficulties and related factors of fatigue, mood, and perceived health have yet to be fully determined. To address this, the current longitudinal study aimed to clarify the trends of cognitive test performance and cognitive domain impairment following COVID-19 infection, and whether hospitalization influenced outcomes. Participants and Methods: 57 participants who reported subjective cognitive complaints after confirmed COVID-19 infection were assessed at baseline (~6 months post COVID-19) and follow-up (~15 months later) visits. Assessments consisted of a comprehensive neuropsychological battery including measures across multiple cognitive domains and self-report questionnaires of fatigue, mood, and overall self-perceived health. Analyses were conducted in three stages: at the test score level (raw and adjusted scores), at the cognitive domain level, and stratified by hospitalization status during infection. Results: At the test-score level, cognitive performance remained relatively stable across assessments, with no significant improvements in any adjusted test scores at follow-up (p > .050). Cognitive domain analyses indicate significant reductions in attention (McNemar’s χ² = 7.26, p = .007) and executive functioning (McNemar’s χ² = 12.00, p < .001) impairment, while memory impairment is slower to resolve. On self-report measures, there was a significant improvement in overall health ratings at follow-up (F_(1,51)= 5.950, p = .018). Finally, those hospitalized during infection performed worse on timed cognitive measures across visits and accounted for a larger proportion of cases with short-term and working memory impairment at follow-up (χ² = 4.66, p = .031). Conclusions: Cognitive difficulties persist both at test score and cognitive domain levels in many cases of post COVID-19 condition, but evidence suggests that there is some improvement in global measures of attention, executive functioning and overall self-rated health at the group level. While other studies have not found hospitalization to be a significant predictor of cognitive deficits in post COVID-19 condition, the results of our long-term follow-up (~21 months after infection) suggest that an effect of hospitalization on cognitive performance may be more discernible in this population year(s) after infection.

Poster

02/16/2024
03:30 pm - 04:45 pm
Room: Shubert Complex (Posters 1-60)

Poster Session 09: Epilepsy | Oncology | MS | Infectious Disease

Final Abstract #45

Longitudinal Neuropsychological Profiles of Post COVID-19 Condition: Reassessing Individuals with Initial Cognitive Complaints in a 1-Year Follow-Up Study

Nicholas Grunden, Concordia University, Montreal, Canada
Marco Calabria, Universitat Oberta de Catalunya, Barcelona, Spain
Carmen García-Sánchez, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Catalina Pons, Blanquerna, Universitat Ramon Llull, Barcelona, Spain
Juan Antonio Arroyo, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Beatriz Gómez-Anson, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
María del Carmen Estévez-García, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Roberto Belvís, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Noemí Morollón, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Mónica Cordero-Carcedo, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Isabel Mur, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Virginia Pomar, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Pere Domingo, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

Category: Infectious Disease (HIV/COVID/Hepatitis/Viruses)

Keyword 1: infectious disease
Keyword 2: cognitive course

Objective:

Cognitive difficulties are reported as lasting sequelae within post COVID-19 condition. However, the chronicity of these difficulties and related factors of fatigue, mood, and perceived health have yet to be fully determined. To address this, the current longitudinal study aimed to clarify the trends of cognitive test performance and cognitive domain impairment following COVID-19 infection, and whether hospitalization influenced outcomes.

Participants and Methods:

57 participants who reported subjective cognitive complaints after confirmed COVID-19 infection were assessed at baseline (~6 months post COVID-19) and follow-up (~15 months later) visits. Assessments consisted of a comprehensive neuropsychological battery including measures across multiple cognitive domains and self-report questionnaires of fatigue, mood, and overall self-perceived health. Analyses were conducted in three stages: at the test score level (raw and adjusted scores), at the cognitive domain level, and stratified by hospitalization status during infection.

Results:

At the test-score level, cognitive performance remained relatively stable across assessments, with no significant improvements in any adjusted test scores at follow-up (p > .050). Cognitive domain analyses indicate significant reductions in attention (McNemar’s χ² = 7.26, p = .007) and executive functioning (McNemar’s χ² = 12.00, p < .001) impairment, while memory impairment is slower to resolve. On self-report measures, there was a significant improvement in overall health ratings at follow-up (F_(1,51)= 5.950, p = .018). Finally, those hospitalized during infection performed worse on timed cognitive measures across visits and accounted for a larger proportion of cases with short-term and working memory impairment at follow-up (χ² = 4.66, p = .031).

Conclusions:

Cognitive difficulties persist both at test score and cognitive domain levels in many cases of post COVID-19 condition, but evidence suggests that there is some improvement in global measures of attention, executive functioning and overall self-rated health at the group level. While other studies have not found hospitalization to be a significant predictor of cognitive deficits in post COVID-19 condition, the results of our long-term follow-up (~21 months after infection) suggest that an effect of hospitalization on cognitive performance may be more discernible in this population year(s) after infection.