INS NYC 2024 Program

Poster	Poster Session 09 Program Schedule 02/16/2024 03:30 pm - 04:45 pm Room: Shubert Complex (Posters 1-60) Poster Session 09: Epilepsy \| Oncology \| MS \| Infectious Disease Final Abstract #35 Associations between Subcortical Gray Matter Volume and Disease Duration in Older Adults with Multiple Sclerosis Ana Eustace, Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, United States Mark Wagshul, Department of Radiology, Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Bronx, United States Roee Holtzer, Department of Neurology, Albert Einstein College of Medicine, Bronx, United States Category: Multiple Sclerosis/ALS/Demyelinating Disorders Keyword 1: multiple sclerosis Keyword 2: neuroimaging: structural Keyword 3: subcortical Objective: Typical onset of Multiple Sclerosis (MS) occurs between ages 20-40 years whereas late onset starts at or after the age of 50 years. Knowledge concerning the impact of disease duration on brain health in Older Adults with Multiple Sclerosis (OAMS) is scarce. We, therefore, examined associations between MS disease duration and Gray Matter Volume (GMV) in OAMS stratified by disease onset type. Participants and Methods: Participants were 94 OAMS age≥60yrs stratified by disease onset type; Typical Onset MS (TOMS, n = 68, mean age = 64.40 years, mean duration = 26.78 years) and Late Onset MS (LOMS, n = 26, mean age = 64.85 years, mean duration = 9.62 years). Years of MS disease duration and GMV, quantified by structural MRI, were measured in each group. GMV was measured, bilaterally, in five subcortical ROIs that have been previously identified in the literature to be vulnerable to MS disease (thalamus, putamen, caudate, pallidum, accumbens). Unadjusted linear regression models were run to examine the association between MS duration and GMV in each ROI in TOMS and LOMS groups. The ROIs that reached significance were rerun in linear regression models adjusted for age and sex. Moderation analyses were run to examine whether the relationship between MS duration and GMV within each sub-group was influenced by chronological age or age of disease onset. Results: In TOMS, unadjusted linear regression models revealed that lower GMV was associated with longer disease duration in several subcortical regions including right accumbens (b = -3.86, p = .003) left accumbens (b = -3.87, p = .007), right putamen (b = -17.18, p = .032), left pallidum (b = -7.51, p = .023), and right thalamus (b = -27.73, p = .016). Models adjusted for age and sex retained significance in right accumbens (b = -3.68, p = .013), left pallidum (b = -8.95, p = .012), and right thalamus (b = -27.63, p = .033). Moderation analyses revealed significant interactions demonstrating the moderating effects of age of disease onset on the relationship between disease duration and GMV in right accumbens (p = .0499), right putamen (p = .018), left putamen (p = .004), and left pallidum (p = .019). Moderating effects of chronological age on the relationship between disease duration and GMV were not significant. In LOMS, associations between disease duration and GMV in any ROIs were not significant. Conclusions: Longer MS disease duration was associated with lower GMV in several subcortical nuclei among patients with typical but not late disease onset. Age of onset but not chronological age further explained these findings. Specifically, associations between disease duration and GMV in the right accumbens, right putamen, left putamen, and left pallidum were stronger among patients with earlier disease onset.

Poster

02/16/2024
03:30 pm - 04:45 pm
Room: Shubert Complex (Posters 1-60)

Poster Session 09: Epilepsy | Oncology | MS | Infectious Disease

Final Abstract #35

Associations between Subcortical Gray Matter Volume and Disease Duration in Older Adults with Multiple Sclerosis

Ana Eustace, Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, United States
Mark Wagshul, Department of Radiology, Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Bronx, United States
Roee Holtzer, Department of Neurology, Albert Einstein College of Medicine, Bronx, United States

Category: Multiple Sclerosis/ALS/Demyelinating Disorders

Keyword 1: multiple sclerosis
Keyword 2: neuroimaging: structural
Keyword 3: subcortical

Objective:

Typical onset of Multiple Sclerosis (MS) occurs between ages 20-40 years whereas late onset starts at or after the age of 50 years. Knowledge concerning the impact of disease duration on brain health in Older Adults with Multiple Sclerosis (OAMS) is scarce. We, therefore, examined associations between MS disease duration and Gray Matter Volume (GMV) in OAMS stratified by disease onset type.

Participants and Methods:

Participants were 94 OAMS age≥60yrs stratified by disease onset type; Typical Onset MS (TOMS, n = 68, mean age = 64.40 years, mean duration = 26.78 years) and Late Onset MS (LOMS, n = 26, mean age = 64.85 years, mean duration = 9.62 years). Years of MS disease duration and GMV, quantified by structural MRI, were measured in each group. GMV was measured, bilaterally, in five subcortical ROIs that have been previously identified in the literature to be vulnerable to MS disease (thalamus, putamen, caudate, pallidum, accumbens). Unadjusted linear regression models were run to examine the association between MS duration and GMV in each ROI in TOMS and LOMS groups. The ROIs that reached significance were rerun in linear regression models adjusted for age and sex. Moderation analyses were run to examine whether the relationship between MS duration and GMV within each sub-group was influenced by chronological age or age of disease onset.

Results:

In TOMS, unadjusted linear regression models revealed that lower GMV was associated with longer disease duration in several subcortical regions including right accumbens (b = -3.86, p = .003) left accumbens (b = -3.87, p = .007), right putamen (b = -17.18, p = .032), left pallidum (b = -7.51, p = .023), and right thalamus (b = -27.73, p = .016). Models adjusted for age and sex retained significance in right accumbens (b = -3.68, p = .013), left pallidum (b = -8.95, p = .012), and right thalamus (b = -27.63, p = .033). Moderation analyses revealed significant interactions demonstrating the moderating effects of age of disease onset on the relationship between disease duration and GMV in right accumbens (p = .0499), right putamen (p = .018), left putamen (p = .004), and left pallidum (p = .019). Moderating effects of chronological age on the relationship between disease duration and GMV were not significant. In LOMS, associations between disease duration and GMV in any ROIs were not significant.

Conclusions:

Longer MS disease duration was associated with lower GMV in several subcortical nuclei among patients with typical but not late disease onset. Age of onset but not chronological age further explained these findings. Specifically, associations between disease duration and GMV in the right accumbens, right putamen, left putamen, and left pallidum were stronger among patients with earlier disease onset.