INS NYC 2024 Program

Poster	Poster Session 08 Program Schedule 02/16/2024 01:45 pm - 03:00 pm Room: Majestic Complex (Posters 61-120) Poster Session 08: Cognition \| Cognitive Reserve Variables Final Abstract #69 The association between habitual sleep duration, depressive symptoms, and cognitive performance changes in a community-based sample of middle-aged adults and older adults Aren Tucker, New York State Psychiatric Institute, New York, United States Hyun Kim, New York State Psychiatric Institute; Columbia University Irving Medical Center, New York, United States Soriul Kim, Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Korea, Republic of Daniel Cohen, University of Arizona, Phoenix, United States Seungku Lee, Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Korea, Republic of Nicole Jisoo Lee, Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Korea, Republic of Seonjoo Lee, New York State Psychiatric Institute; Mailman School of Public Health, Columbia University, New York, United States Terry Goldberg, New York State Psychiatric Institute; Columbia University Irving Medical Center, New York, United States Chol Shin, Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Korea, Republic of Category: Sleep and Sleep Disorders Keyword 1: sleep Keyword 2: depression Keyword 3: cognitive functioning Objective: Cumulating evidence suggests that habitual sleep duration is an important health indicator that also impacts cognitive and brain aging. While most previous studies examined sleep duration as categorical variable (e.g., <6 hrs vs. 7-8 hours vs. 8+ hours), examining sleep duration as continuous variable would enhance analytic power and allow us to test both linear and quadratic terms, which could clarify the role of sleep duration on cognitive health furthermore. While depression is also associated with aberrant sleep durations (short or excessive) and cognitive performance, it is also crucial to assess the role of depressive symptoms in the relationship between sleep and cognition. Therefore, the current study investigated the role of habitual sleep duration in middle-aged and older adults on cognitive changes over 4 years. The role of depressive symptoms was also examined. Participants and Methods: Study sample included 2,286 individuals from the Korean Genome and Epidemiology Study (KoGES) (mean age 58.8±6.9) at baseline, 48.2% female) who were dementia-free and had both sleep and neuropsychological test data at the baseline examination (Years 2011-2014). Follow-up examinations were conducted during years 2015-2018. Sleep duration was measured at each visit as part of the Pittsburgh Sleep Quality Index, and presented in average hours per night during the past one month as a continuous variable. Additionally, sleep duration was presented in both linear and quadratic terms (sleep duration hours2) to test non-linear relationship between sleep duration and cognitive performance. Cognitive outcomes included measures of verbal and visual memory (Logical Memory and Visual Reproductions) along with measures of frontal network functioning, such as attention and executive functions (Trail Making Tests A and B, Digit Symbol, and Stroop Word and Color Word tests). The interaction between sleep duration and apolipoprotein-e4 genotype (APOE4) on cognitive outcomes was evaluated using the linear regressions, controlling for age, sex, education, body mass index, cardiovascular diseases, smoking, alcohol consumption, sedatives/hypnotics use, and depressive symptoms (using the Beck Depression Inventory [BDI]). Results: Sleep duration at baseline, examined as a linear term, had a significant association with changes in the Digit Symbol test (β=2.23, F=5.04, P=0.02) over the course of 4 years, indicating a significantly faster decline in performance with shorter baseline sleep duration. When sleep duration was examined in quadratic terms (sleep2), it was not associated with the Digit Symbol but was significantly associated with performance change on the TMT-B test (F=9.63, P=0.002), suggesting that both short and excessive sleep durations were associated with poorer performance (inverted U-shape curve). These associations remained significant even after adjusting for total BDI score. Conclusions: Habitual sleep duration in late-middle adulthood and early older adulthood was significantly associated with some areas of frontal network functioning, including sustained attention, working memory, and executive functions (particularly set shifting). This relationship was not modified by the presence of depressive symptoms. Our findings suggest that causes of short or excessive sleep duration should be carefully examined and targeted in the aging population for enhanced cognitive health.

Poster

02/16/2024
01:45 pm - 03:00 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 08: Cognition | Cognitive Reserve Variables

Final Abstract #69

The association between habitual sleep duration, depressive symptoms, and cognitive performance changes in a community-based sample of middle-aged adults and older adults

Aren Tucker, New York State Psychiatric Institute, New York, United States
Hyun Kim, New York State Psychiatric Institute; Columbia University Irving Medical Center, New York, United States
Soriul Kim, Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Korea, Republic of
Daniel Cohen, University of Arizona, Phoenix, United States
Seungku Lee, Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Korea, Republic of
Nicole Jisoo Lee, Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Korea, Republic of
Seonjoo Lee, New York State Psychiatric Institute; Mailman School of Public Health, Columbia University, New York, United States
Terry Goldberg, New York State Psychiatric Institute; Columbia University Irving Medical Center, New York, United States
Chol Shin, Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Korea, Republic of

Category: Sleep and Sleep Disorders

Keyword 1: sleep
Keyword 2: depression
Keyword 3: cognitive functioning

Objective:

Cumulating evidence suggests that habitual sleep duration is an important health indicator that also impacts cognitive and brain aging. While most previous studies examined sleep duration as categorical variable (e.g., <6 hrs vs. 7-8 hours vs. 8+ hours), examining sleep duration as continuous variable would enhance analytic power and allow us to test both linear and quadratic terms, which could clarify the role of sleep duration on cognitive health furthermore. While depression is also associated with aberrant sleep durations (short or excessive) and cognitive performance, it is also crucial to assess the role of depressive symptoms in the relationship between sleep and cognition. Therefore, the current study investigated the role of habitual sleep duration in middle-aged and older adults on cognitive changes over 4 years. The role of depressive symptoms was also examined.

Participants and Methods:

Study sample included 2,286 individuals from the Korean Genome and Epidemiology Study (KoGES) (mean age 58.8±6.9) at baseline, 48.2% female) who were dementia-free and had both sleep and neuropsychological test data at the baseline examination (Years 2011-2014). Follow-up examinations were conducted during years 2015-2018. Sleep duration was measured at each visit as part of the Pittsburgh Sleep Quality Index, and presented in average hours per night during the past one month as a continuous variable. Additionally, sleep duration was presented in both linear and quadratic terms (sleep duration hours2) to test non-linear relationship between sleep duration and cognitive performance. Cognitive outcomes included measures of verbal and visual memory (Logical Memory and Visual Reproductions) along with measures of frontal network functioning, such as attention and executive functions (Trail Making Tests A and B, Digit Symbol, and Stroop Word and Color Word tests). The interaction between sleep duration and apolipoprotein-e4 genotype (APOE4) on cognitive outcomes was evaluated using the linear regressions, controlling for age, sex, education, body mass index, cardiovascular diseases, smoking, alcohol consumption, sedatives/hypnotics use, and depressive symptoms (using the Beck Depression Inventory [BDI]).

Results:

Sleep duration at baseline, examined as a linear term, had a significant association with changes in the Digit Symbol test (β=2.23, F=5.04, P=0.02) over the course of 4 years, indicating a significantly faster decline in performance with shorter baseline sleep duration. When sleep duration was examined in quadratic terms (sleep2), it was not associated with the Digit Symbol but was significantly associated with performance change on the TMT-B test (F=9.63, P=0.002), suggesting that both short and excessive

sleep durations were associated with poorer performance (inverted U-shape curve). These associations remained significant even after adjusting for total BDI score.

Conclusions:

Habitual sleep duration in late-middle adulthood and early older adulthood was significantly associated with some areas of frontal network functioning, including sustained attention, working memory, and executive functions (particularly set shifting). This relationship was not modified by the presence of depressive symptoms. Our findings suggest that causes of short or excessive sleep duration should be carefully examined and targeted in the aging population for enhanced cognitive health.