INS NYC 2024 Program

Epilepsy is one of the most common brain disorders, may occur at all ages and have many possible explanations and causes Factors such as early reaction to underlying etiology, medication, and number of seizures prior to initiation of treatment have frequently been found to be predictive of seizure cognitive outcomes in epilepsy patients. In addition, Wide range of cognitive difficulties are reported frequently in epilepsy, Studies suggest that the relationship between neurological insult and cognitive outcome can be moderated by cognitive reserve (CR) and brain reserve (BR) which claim that intellectual enrichment and intelligence, and larger brain size protect against neuropathology. There is scant data on CR, BR, epilepsy, and cognitive outcome of chronic epilepsy. The purpose of the current study is to investigate the interaction between severity of the disease, BR, CR, and cognitive status in epilepsy patients. This study is a retrospective study involves a consecutive series of 40 patients with TLE epilepsy that were admitted to the epilepsy clinic at Rambam Medical Center, Israel. Cognitive reserve as an independent variable will be estimate by years of education, employment status, family status, socioeconomic status and Brain reserve as an independent variable will be estimated by using various brain measures based on the MRI scanning of the patients, Cognitive outcome will be estimate by neurocognitive tests such as Wisconsin Card Sorting Test and Figural Learning Test DCS. In order to test these hypotheses, we are going to use Linear Regression analyses and Path modeling analyses.