INS NYC 2024 Program

Poster	Poster Session 08 Program Schedule 02/16/2024 01:45 pm - 03:00 pm Room: Shubert Complex (Posters 1-60) Poster Session 08: Cognition \| Cognitive Reserve Variables Final Abstract #7 Association of Atherosclerotic Cardiovascular Risk with Cognitive Performance in a Representative Community Sample: A Ten-Year Follow-Up Danyah Ahmed, UT Southwestern, Dallas, United States Anthony Longoria, UT Southwestern, Dallas, United States Jessica Helphrey, UT Southwesten.edu, Dallas, United States James de Lemos, UT Southwesten, Dallas, United States Christian LoBue, UT Southwestern, Dallas, United States Laura Lacritz, UT Southwestern, Dallas, United States Category: MCI (Mild Cognitive Impairment) Keyword 1: cardiovascular disease Keyword 2: cognitive functioning Keyword 3: neuropsychological assessment Objective: The Framingham risk score is a well-established tool used to estimate the 10-year cardiovascular disease (CVD) risk of an individual. Cross-sectional studies have established that higher risk scores are associated with poorer cognitive functioning, though there are fewer longitudinal studies to determine impact on cognitive abilities over time. The aim of this study is to investigate the association between the Framingham CVD risk score and cognitive functioning 10 years later among a community-dwelling sample of older adults. Participants and Methods: Participants (N= 588; Age M̄ =61.7, Female= 59.6%, Non-Hispanic Black 40.0%, Hispanic/Latinx=10.4%, Education M=14.7) completed Phase 2 of the Dallas Heart Study (DHS-2; Time 1) and returned approximately 10 years later for Phase 3 (Time 2). At Time 1, a 10-year Framingham CVD risk score (Range: 1-25; M̄= 3.4. SD=4.5) was calculated based on age, sex, cholesterol, glucose, and hemoglobin levels (obtained from a lab sequence), history of hypertension, average of three blood pressure readings, presence/absence of diabetes, and smoking status. Participants were administered the Montreal Cognitive Assessment (MoCA) at baseline. At Time 2, a cognitive battery that included the MoCA, Wechsler Test of Adult Reading (WTAR), CERAD list-learning task, Trails A&B, Wechsler Adult Intelligence Scale - Fourth Edition (WAIS-IV) Coding, and Animal Fluency was conducted. Z-scores were calculated for each test. Change in MoCA was calculated as the ratio of change in MoCA total score over baseline total score. A series of multiple linear regressions were conducted to determine if baseline CVD risk scores were associated with cognitive performance at Time 2. Results: Of the total sample at Time 1, 8% had diabetes, 14.5% were current smokers, 22.1% were past smokers, 35.9% were hypertensive, and 28.1% were hypercholesterolemic. Eighty-eight percent of participants were classified as low (<10% chance of developing CVD), 7.3% were moderate risk (10-20%), and 1.6% were high risk (>20%). Regression analyses revealed that higher Framingham CVD risk scores were associated with poorer performance on CERAD total words (β=-0.29, p<.001) and Trails-B (β=0.11, p<.05), and predicted a larger reduction in MoCA total scores (β=0.14, p<.05) from Time 1 to Time 2 controlling for age, sex, ethnoracial group, estimated intelligence, and income level. Conclusions: This study evaluated the association of Framingham risk scores with cognitive performance 10 years later in a probabilistic community sample. Consistent with previous literature, significant associations were found between cardiovascular risk and decreased cognitive performance. This is particularly noteworthy given that the sample contained predominantly low risk individuals. Future research may benefit from examining trajectories of cognitive decline by baseline level of CVD risk (i.e., low, medium, high) to better understand what threshold of CVD risk is most likely to be associated with future cognitive decline.

Poster

02/16/2024
01:45 pm - 03:00 pm
Room: Shubert Complex (Posters 1-60)

Poster Session 08: Cognition | Cognitive Reserve Variables

Final Abstract #7

Association of Atherosclerotic Cardiovascular Risk with Cognitive Performance in a Representative Community Sample: A Ten-Year Follow-Up

Danyah Ahmed, UT Southwestern, Dallas, United States
Anthony Longoria, UT Southwestern, Dallas, United States
Jessica Helphrey, UT Southwesten.edu, Dallas, United States
James de Lemos, UT Southwesten, Dallas, United States
Christian LoBue, UT Southwestern, Dallas, United States
Laura Lacritz, UT Southwestern, Dallas, United States

Category: MCI (Mild Cognitive Impairment)

Keyword 1: cardiovascular disease
Keyword 2: cognitive functioning
Keyword 3: neuropsychological assessment

Objective:

The Framingham risk score is a well-established tool used to estimate the 10-year cardiovascular disease (CVD) risk of an individual. Cross-sectional studies have established that higher risk scores are associated with poorer cognitive functioning, though there are fewer longitudinal studies to determine impact on cognitive abilities over time. The aim of this study is to investigate the association between the Framingham CVD risk score and cognitive functioning 10 years later among a community-dwelling sample of older adults.

Participants and Methods:

Participants (N= 588; Age M̄ =61.7, Female= 59.6%, Non-Hispanic Black 40.0%, Hispanic/Latinx=10.4%, Education M=14.7) completed Phase 2 of the Dallas Heart Study (DHS-2; Time 1) and returned approximately 10 years later for Phase 3 (Time 2). At Time 1, a 10-year Framingham CVD risk score (Range: 1-25; M̄= 3.4. SD=4.5) was calculated based on age, sex, cholesterol, glucose, and hemoglobin levels (obtained from a lab sequence), history of hypertension, average of three blood pressure readings, presence/absence of diabetes, and smoking status. Participants were administered the Montreal Cognitive Assessment (MoCA) at baseline. At Time 2, a cognitive battery that included the MoCA, Wechsler Test of Adult Reading (WTAR), CERAD list-learning task, Trails A&B, Wechsler Adult Intelligence Scale - Fourth Edition (WAIS-IV) Coding, and Animal Fluency was conducted. Z-scores were calculated for each test. Change in MoCA was calculated as the ratio of change in MoCA total score over baseline total score. A series of multiple linear regressions were conducted to determine if baseline CVD risk scores were associated with cognitive performance at Time 2.

Results:

Of the total sample at Time 1, 8% had diabetes, 14.5% were current smokers, 22.1% were past smokers, 35.9% were hypertensive, and 28.1% were hypercholesterolemic. Eighty-eight percent of participants were classified as low (<10% chance of developing CVD), 7.3% were moderate risk (10-20%), and 1.6% were high risk (>20%). Regression analyses revealed that higher Framingham CVD risk scores were associated with poorer performance on CERAD total words (β=-0.29, p<.001) and Trails-B (β=0.11, p<.05), and predicted a larger reduction in MoCA total scores (β=0.14, p<.05) from Time 1 to Time 2 controlling for age, sex, ethnoracial group, estimated intelligence, and income level.

Conclusions:

This study evaluated the association of Framingham risk scores with cognitive performance 10 years later in a probabilistic community sample. Consistent with previous literature, significant associations were found between cardiovascular risk and decreased cognitive performance. This is particularly noteworthy given that the sample contained predominantly low risk individuals. Future research may benefit from examining trajectories of cognitive decline by baseline level of CVD risk (i.e., low, medium, high) to better understand what threshold of CVD risk is most likely to be associated with future cognitive decline.