INS NYC 2024 Program

Poster	Poster Session 06 Program Schedule 02/15/2024 04:00 pm - 05:15 pm Room: Majestic Complex (Posters 61-120) Poster Session 06: Aging \| MCI \| Neurodegenerative Disease - PART 2 Final Abstract #90 Factors Predicting Fear of Alzheimer’s Disease Among Women with a Family History Jessica Rodrigues, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States Katie Stypulkowski, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States Nikki Kaplan, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States Shehroo Pudumjee, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States Jessica Caldwell, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States Category: Aging Keyword 1: memory complaints Objective: The Women’s Alzheimer’s Movement Prevention Center at Cleveland Clinic (WAMPC) assesses women’s current overall health and offers lifestyle modifications to reduce risk of Alzheimer’s disease (AD) and promote optimal brain health, specifically for women with an established family history of AD or confirmed genetic risk. We sought to examine factors that predicted a fear of developing AD within this at-risk cohort. Participants and Methods: For women who consented to be part of a research registry (n=166; 91% White, M_age=53.38, SD_age=10.16), questionnaire data from initial clinic visits were reviewed. Measures of interest included the Center for Epidemiologic Studies Depression Scale (CES-D), Beck Anxiety Inventory (BAI), Medical Outcomes Scale (MOS: Sleep Problems Index), the Memory Controllability Inventory (MCI), and the Fear of Alzheimer’s Disease Scale (FADS). A stepwise regression model was constructed including age, years of education, depression, anxiety, and sleep as predictors of fear of AD. A second stepwise regression model examined women’s perceptions about their memory using the MCI subscales as predictors of fear of Alzheimer’s disease, including beliefs about one’s memory performance, ability to change their memory, and the inevitability of cognitive decline or dementia. Results: The CESD predicted fear of AD (β=.34, t(149)=4.45, p;<.01) and explained 11.7% of the variance (R²=.12, F(1, 149)=19.76, p <.01). Participant age, years of education, anxiety, and sleep problems were not significant predictors and were excluded from the model. In the second model, the Alzheimer’s Likelihood subscale explained 41.2% (R²=.41, β=.537, F(1, 164)=115.04, p<.01) of the variance in total FADS score, with an additional 4.1% (β=.20) of the variance explained by the Inevitable Decrement subscale and another 1.5% (β=-.13) explained by the Present Ability subscale. MCI subscales of Potential Improvement and Effort Utility were not significant predictors of FADS total score. Conclusions: In a sample of women at risk for AD, greater self-reported depression symptoms predicted increased fear of developing AD. Additionally, when looking at women’s attitudes about their own memory, stronger beliefs in the inevitability of cognitive decline and AD, as well as belief that their present memory is poor, were predictive of fear of developing AD. Considering women’s perception about their ability to improve their memory was not a significant factor in predicting fear of AD, the present analyses suggest more work is needed to assess whether more pessimistic judgments of future memory outcomes contribute to a perceived lack of control about memory and cognition. As depression and negative outlooks about the present and future were separately determined to increase fear of AD, future research may examine how these factors interact. Further, future directions include examining whether addressing depression and women’s perception about their cognitive functioning and possible cognitive decline will 1) impact adherence to lifestyle modifications and 2) impact future fear of AD.

Poster

02/15/2024
04:00 pm - 05:15 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 06: Aging | MCI | Neurodegenerative Disease - PART 2

Final Abstract #90

Factors Predicting Fear of Alzheimer’s Disease Among Women with a Family History

Jessica Rodrigues, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States
Katie Stypulkowski, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States
Nikki Kaplan, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States
Shehroo Pudumjee, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States
Jessica Caldwell, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States

Category: Aging

Keyword 1: memory complaints

Objective:

The Women’s Alzheimer’s Movement Prevention Center at Cleveland Clinic (WAMPC) assesses women’s current overall health and offers lifestyle modifications to reduce risk of Alzheimer’s disease (AD) and promote optimal brain health, specifically for women with an established family history of AD or confirmed genetic risk. We sought to examine factors that predicted a fear of developing AD within this at-risk cohort.

Participants and Methods:

For women who consented to be part of a research registry (n=166; 91% White, M_age=53.38, SD_age=10.16), questionnaire data from initial clinic visits were reviewed. Measures of interest included the Center for Epidemiologic Studies Depression Scale (CES-D), Beck Anxiety Inventory (BAI), Medical Outcomes Scale (MOS: Sleep Problems Index), the Memory Controllability Inventory (MCI), and the Fear of Alzheimer’s Disease Scale (FADS). A stepwise regression model was constructed including age, years of education, depression, anxiety, and sleep as predictors of fear of AD. A second stepwise regression model examined women’s perceptions about their memory using the MCI subscales as predictors of fear of Alzheimer’s disease, including beliefs about one’s memory performance, ability to change their memory, and the inevitability of cognitive decline or dementia.

Results:

The CESD predicted fear of AD (β=.34, t(149)=4.45, p;<.01) and explained 11.7% of the variance (R²=.12, F(1, 149)=19.76, p <.01). Participant age, years of education, anxiety, and sleep problems were not significant predictors and were excluded from the model. In the second model, the Alzheimer’s Likelihood subscale explained 41.2% (R²=.41, β=.537, F(1, 164)=115.04, p<.01) of the variance in total FADS score, with an additional 4.1% (β=.20) of the variance explained by the Inevitable Decrement subscale and another 1.5% (β=-.13) explained by the Present Ability subscale. MCI subscales of Potential Improvement and Effort Utility were not significant predictors of FADS total score.

Conclusions:

In a sample of women at risk for AD, greater self-reported depression symptoms predicted increased fear of developing AD. Additionally, when looking at women’s attitudes about their own memory, stronger beliefs in the inevitability of cognitive decline and AD, as well as belief that their present memory is poor, were predictive of fear of developing AD. Considering women’s perception about their ability to improve their memory was not a significant factor in predicting fear of AD, the present analyses suggest more work is needed to assess whether more pessimistic judgments of future memory outcomes contribute to a perceived lack of control about memory and cognition. As depression and negative outlooks about the present and future were separately determined to increase fear of AD, future research may examine how these factors interact. Further, future directions include examining whether addressing depression and women’s perception about their cognitive functioning and possible cognitive decline will 1) impact adherence to lifestyle modifications and 2) impact future fear of AD.