INS NYC 2024 Program

Poster	Poster Session 06 Program Schedule 02/15/2024 04:00 pm - 05:15 pm Room: Majestic Complex (Posters 61-120) Poster Session 06: Aging \| MCI \| Neurodegenerative Disease - PART 2 Final Abstract #87 Quality of Life in Patients with Korsakoff’s Syndrome Yvonne Rensen, Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, Netherlands Corrie Waal, 2Regional Expertise Centre Het Dijckhuis, het Parkhuis, Dordrecht, Netherlands Roy Kessels, Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, Netherlands Category: Memory Functions/Amnesia Keyword 1: quality of life Keyword 2: Korsakoff's syndrome/Wernicke’s encephalopathy Keyword 3: assessment Objective: Due to severe cognitive impairments and neuropsychiatric symptoms, most patients with Korsakoff’s syndrome (KS) are in need of lifelong specialized care. Unfortunately, many patients with KS become frustrated in long-term care settings, as they may not fully comprehend why they are unable to live independently, due to lack of illness insight. This might negatively influence their overall quality of life (QoL). Recently, the QUALIKO was developed, an observation scale for assessing QoL in residential patients with KS. There are no instruments available for measuring self-reported QoL in patients with KS. The aim of this study was to validate a self-report version of the QUALIKO, which includes the same subscales as the informant version. We examined 1) differences in self- and informant rated QoL in patients with KS, 2) the construct validity of the self-report QoL instrument, and 3) examined whether QoL and cognitive functioning was significantly related. Participants and Methods: One hundred-seventeen patients with KS participated in this study, recruited from three nursing homes with a regional expertise centre (REC) status, and one regular nursing home, all having specialized units exclusively for patients with KS. The QUALIKO was completed by caregivers who knew the patients well. Patients filled in the self-report version, the QUALIKO-SR, the Manchester Short Assessment of Quality of Life-16 (MANSA-16) and they completed the Montreal Cognitive Assessment 8.1 (MoCA 8.1). Results: 1) There was no significant difference between the patients and caregivers ratings of the overall QoL (both rated a 6.9 on a scale from 1 = very bad to 10 = very good). There were no significant differences in the ratings of the patients and caregivers on the QUALIKO subscales Care Relationship, Positive Affect, Restless Tense Behavior, Positive Self-image, Social Relations, and Meaningful activity. Patients rated themselves significantly lower than their caregivers on the subscales: Autonomy, Negative Affect, Social Isolation and Feeling at Home. 2) Significant, positive correlations were found between the QUALIBO total score and 7 out of 9 subscales and the MANSA-16 total score. 3) Self-reported and caregiver reported QoL was not significantly related to cognitive performance on the MoCA. Conclusions: Overall, caregivers and patients with KS agree on the general QoL of the patients and on most subscales of a QoL instrument. However, patients rated themselves lower on autonomy, negative affect, social isolation and feeling at home. Negative feelings of patients with KS in nursing homes on these topics might be underestimated by caregivers. Despite the severe cognitive impairments and lack of illness insight, it is important to (also) ask the patients themselves, when assessing their QoL. This first study with the QUALIKO-SP indicates that the this might be a valid self-report instrument for assessing QoL in patients with KS, and can be used next to the informant version.

Poster

02/15/2024
04:00 pm - 05:15 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 06: Aging | MCI | Neurodegenerative Disease - PART 2

Final Abstract #87

Quality of Life in Patients with Korsakoff’s Syndrome

Yvonne Rensen, Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, Netherlands
Corrie Waal, 2Regional Expertise Centre Het Dijckhuis, het Parkhuis, Dordrecht, Netherlands
Roy Kessels, Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, Netherlands

Category: Memory Functions/Amnesia

Keyword 1: quality of life
Keyword 2: Korsakoff's syndrome/Wernicke’s encephalopathy
Keyword 3: assessment

Objective:

Due to severe cognitive impairments and neuropsychiatric symptoms, most patients with Korsakoff’s syndrome (KS) are in need of lifelong specialized care. Unfortunately, many patients with KS become frustrated in long-term care settings, as they may not fully comprehend why they are unable to live independently, due to lack of illness insight. This might negatively influence their overall quality of life (QoL). Recently, the QUALIKO was developed, an observation scale for assessing QoL in residential patients with KS. There are no instruments available for measuring self-reported QoL in patients with KS. The aim of this study was to validate a self-report version of the QUALIKO, which includes the same subscales as the informant version. We examined 1) differences in self- and informant rated QoL in patients with KS, 2) the construct validity of the self-report QoL instrument, and 3) examined whether QoL and cognitive functioning was significantly related.

Participants and Methods:

One hundred-seventeen patients with KS participated in this study, recruited from three nursing homes with a regional expertise centre (REC) status, and one regular nursing home, all having specialized units exclusively for patients with KS. The QUALIKO was completed by caregivers who knew the patients well. Patients filled in the self-report version, the QUALIKO-SR, the Manchester Short Assessment of Quality of Life-16 (MANSA-16) and they completed the Montreal Cognitive Assessment 8.1 (MoCA 8.1).

Results:

1) There was no significant difference between the patients and caregivers ratings of the overall QoL (both rated a 6.9 on a scale from 1 = very bad to 10 = very good). There were no significant differences in the ratings of the patients and caregivers on the QUALIKO subscales Care Relationship, Positive Affect, Restless Tense Behavior, Positive Self-image, Social Relations, and Meaningful activity. Patients rated themselves significantly lower than their caregivers on the subscales: Autonomy, Negative Affect, Social Isolation and Feeling at Home. 2) Significant, positive correlations were found between the QUALIBO total score and 7 out of 9 subscales and the MANSA-16 total score. 3) Self-reported and caregiver reported QoL was not significantly related to cognitive performance on the MoCA.

Conclusions:

Overall, caregivers and patients with KS agree on the general QoL of the patients and on most subscales of a QoL instrument. However, patients rated themselves lower on autonomy, negative affect, social isolation and feeling at home. Negative feelings of patients with KS in nursing homes on these topics might be underestimated by caregivers. Despite the severe cognitive impairments and lack of illness insight, it is important to (also) ask the patients themselves, when assessing their QoL. This first study with the QUALIKO-SP indicates that the this might be a valid self-report instrument for assessing QoL in patients with KS, and can be used next to the informant version.