INS NYC 2024 Program

Poster	Poster Session 06 Program Schedule 02/15/2024 04:00 pm - 05:15 pm Room: Majestic Complex (Posters 61-120) Poster Session 06: Aging \| MCI \| Neurodegenerative Disease - PART 2 Final Abstract #82 Mild Cognitive Impairment Subtypes Associated with Abnormal Functional Activation During Response Inhibition Jessica Pommy, Medical College of Wisconsin, Milwaukee, United States Alexander Cohen, Medical College of Wisconsin, Milwaukee, United States Zachariah Hoell, Medical College of Wisconsin, milwaukee, United States Kelly Ristow, Medical College of Wisconsin, Milwaukee, United States Laura Umfleet, Medical College of Wisconsin, Milwaukee, United States Malgorzata Franczak, Medical College of Wisconsin, Milwaukee, United States Andrew Bryant, Ohio State University, Columbus, United States Colette Smart, University of Victoria, Victoria, Canada Carrie Cook, OhioHealth, Columbus, United States Lilly Mason, Medical College of Wisconsin, Milwaukee, United States Yang Wang, Medical College of Wisconsin, Milwaukee, United States Category: MCI (Mild Cognitive Impairment) Keyword 1: inhibitory control Keyword 2: mild cognitive impairment Keyword 3: neuroimaging: functional Objective: The ability to inhibit responses decreases in both typical aging and neurodegeneration including mild cognitive impairment (MCI). The increased utilization of frontoparietal regions during tasks requiring response inhibition has been interpreted as the manifestation of a compensatory mechanism in older adults. While electrophysiological research indicates that the decrease in response inhibition in MCI is comparable to the process seen in normal aging, albeit more pronounced, a comprehensive investigation using functional MRI (fMRI) is yet to be conducted. Specifically, the variations between MCI subtypes have not been fully determined. Participants and Methods: 22 adult patients with MCI (M age=67.2, 14 male, 12 amnestic, 10 non-amnestic) and 31 cognitively normal older adults (M age=73.6, 9 male) performed a Go/NoGo task during a functional MR scan acquired using the novel multiband multi-echo (MBME) techniques. Group differences in task performance (i.e., reaction time, accuracy) were examined. Individual BOLD signal change during the GNG task was examined and then a voxel-wise group comparison was conducted for MCI vs. HC groups, using age, gender, education, and gray matter density as covariates. Permutation-estimated cluster size at alpha <.05 was defined to correct for errors of multiple comparisons. Results: Although the MCI group made a significantly greater number of errors during Go and NoGo trials (p<.001, p=.032, respectively), there were no significant group differences between MCI subtypes. However, during go trials, the MCI group exhibited greater activation in the Default Mode Network (DMN) and right insula (corrected p<0.05) compared to the HC group, while during NoGo trials, the MCI group showed greater activation in the anterior default mode network (DMN), right dorsolateral prefrontal cortex (DLPFC), and motor areas. Although there were no significant task performance differences between MCI subtypes (amnestic vs. non-amnestic), amnestic MCI (aMCI) showed more activation in the posterior DMN and dorsal attention area during NoGo trials (corrected p<0.05). Follow-up analyses revealed that group differences between MCI subtypes were driven by differences in deactivation, with Amnestic MCI exhibiting significantly lower deactivation (with no significant differences in activation) than non-amnestic MCI in a cluster within the posterior DMN compared to non-amnestic MCI. Conclusions: Compared to a typical group of older adults, the cohort with MCI demonstrated significantly greater activation during both Go and NoGo trials and made significantly more errors. Although the MCI subtypes did not exhibit differences in task performance, group differences in activation between MCI subtypes were revealed by lower deactivation within the amnestic MCI subtype. Our findings suggest that the MCI cohort exhibits inefficient suppression of the DMN during task performance, particularly in the aMCI subgroup.

Poster

02/15/2024
04:00 pm - 05:15 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 06: Aging | MCI | Neurodegenerative Disease - PART 2

Final Abstract #82

Mild Cognitive Impairment Subtypes Associated with Abnormal Functional Activation During Response Inhibition

Jessica Pommy, Medical College of Wisconsin, Milwaukee, United States
Alexander Cohen, Medical College of Wisconsin, Milwaukee, United States
Zachariah Hoell, Medical College of Wisconsin, milwaukee, United States
Kelly Ristow, Medical College of Wisconsin, Milwaukee, United States
Laura Umfleet, Medical College of Wisconsin, Milwaukee, United States
Malgorzata Franczak, Medical College of Wisconsin, Milwaukee, United States
Andrew Bryant, Ohio State University, Columbus, United States
Colette Smart, University of Victoria, Victoria, Canada
Carrie Cook, OhioHealth, Columbus, United States
Lilly Mason, Medical College of Wisconsin, Milwaukee, United States
Yang Wang, Medical College of Wisconsin, Milwaukee, United States

Category: MCI (Mild Cognitive Impairment)

Keyword 1: inhibitory control
Keyword 2: mild cognitive impairment
Keyword 3: neuroimaging: functional

Objective:

The ability to inhibit responses decreases in both typical aging and neurodegeneration including mild cognitive impairment (MCI). The increased utilization of frontoparietal regions during tasks requiring response inhibition has been interpreted as the manifestation of a compensatory mechanism in older adults. While electrophysiological research indicates that the decrease in response inhibition in MCI is comparable to the process seen in normal aging, albeit more pronounced, a comprehensive investigation using functional MRI (fMRI) is yet to be conducted. Specifically, the variations between MCI subtypes have not been fully determined.

Participants and Methods:

22 adult patients with MCI (M age=67.2, 14 male, 12 amnestic, 10 non-amnestic) and 31 cognitively normal older adults (M age=73.6, 9 male) performed a Go/NoGo task during a functional MR scan acquired using the novel multiband multi-echo (MBME) techniques. Group differences in task performance (i.e., reaction time, accuracy) were examined. Individual BOLD signal change during the GNG task was examined and then a voxel-wise group comparison was conducted for MCI vs. HC groups, using age, gender, education, and gray matter density as covariates. Permutation-estimated cluster size at alpha <.05 was defined to correct for errors of multiple comparisons.

Results:

Although the MCI group made a significantly greater number of errors during Go and NoGo trials (p<.001, p=.032, respectively), there were no significant group differences between MCI subtypes. However, during go trials, the MCI group exhibited greater activation in the Default Mode Network (DMN) and right insula (corrected p<0.05) compared to the HC group, while during NoGo trials, the MCI group showed greater activation in the anterior default mode network (DMN), right dorsolateral prefrontal cortex (DLPFC), and motor areas. Although there were no significant task performance differences between MCI subtypes (amnestic vs. non-amnestic), amnestic MCI (aMCI) showed more activation in the posterior DMN and dorsal attention area during NoGo trials (corrected p<0.05). Follow-up analyses revealed that group differences between MCI subtypes were driven by differences in deactivation, with Amnestic MCI exhibiting significantly lower deactivation (with no significant differences in activation) than non-amnestic MCI in a cluster within the posterior DMN compared to non-amnestic MCI.

Conclusions:

Compared to a typical group of older adults, the cohort with MCI demonstrated significantly greater activation during both Go and NoGo trials and made significantly more errors. Although the MCI subtypes did not exhibit differences in task performance, group differences in activation between MCI subtypes were revealed by lower deactivation within the amnestic MCI subtype. Our findings suggest that the MCI cohort exhibits inefficient suppression of the DMN during task performance, particularly in the aMCI subgroup.