INS NYC 2024 Program

Poster	Poster Session 06 Program Schedule 02/15/2024 04:00 pm - 05:15 pm Room: Majestic Complex (Posters 61-120) Poster Session 06: Aging \| MCI \| Neurodegenerative Disease - PART 2 Final Abstract #72 Determinants of Confrontation Naming Deficits on the Boston Naming Test in Participants with TAR DNA-Binding Protein 43 Carling Robinson, Mayo Clini, Rochester, United States Austin Goodrich, Mayo Clinic, Rochester, United States Stephen Weigand, Mayo Clinic, Rochester, United States Nha Trang Thu Pham, Mayo Clinic, Rochester, United States Arenn Carlos, Mayo Clinic, Rochester, United States Marina Buciuc, Medical University of South Carolina, Charleston, United States Melissa Murray, Mayo Clinic, Jacksonville, United States Aivi Nguyen, Mayo Clinic, Rochester, United States R. Reichard, Mayo Clinic, Rochester, United States David Knopman, Mayo Clinic, Rochester, United States Ronald Petersen, Mayo Clinic, Rochester, United States Dennis Dickson, Mayo Clinic, Jacksonville, United States Rene Utianski, Mayo Clinic, Rochester, United States Jennifer Whitwell, Mayo Clinic, Rochester, United States Keith Josephs, Mayo Clinic, Rochester, United States Mary Machulda, Mayo Clinic, Rochester, United States Category: Neurodegenerative Disorders Keyword 1: naming Objective: To examine performance on the Boston Naming Test (BNT) in individuals with Alzheimer’s disease neuropathologic changes (ADNC) who are TAR DNA-binding protein of 43 kDa positive (TDP-43+). We hypothesized that TDP-43+ participants would benefit less from phonemic cues, thus suggesting a loss of word knowledge rather than retrieval-based difficulties. Participants and Methods: We performed a retrospective clinicopathologic study on 282 participants with ADNC and known TDP-43 status. We evaluated item-level performance in response to phonemic cues on the 60-item BNT for first and last available assessments. We fit cross-sectional negative binomial count models that assessed (1) total number of BNT errors; and (2) number correct with phonemic cue (i.e., retrieval-based deficit) versus “I don’t know” (IDK) responses (i.e., interpreted as loss of word knowledge) at the first and last assessments. Models included TDP-43 status and adjusted for sex, age at the time of BNT test, years of education, years from the test to death, and ADNC rating. A sensitivity analysis stratified by high vs low-intermediate ADNC was also performed. For models that evaluated the last assessment, we adjusted for number of prior exposures to the BNT. Results: Of the 282 participants, 42.5% were TDP-43+ and 57.5% were TDP-43-. Median ages at baseline were similar (81 years and 82 years, respectively; p =.62), but the TDP-43+ group had a trend for a higher fraction of women (58% vs. 48%; p=.07). The TDP-43+ group had more APOE e4 carriers (40% vs 28%; p=.036) and a longer time from baseline to death (median 8.4 years vs. 6.1 years; p=.001) compared to the TDP-43- group. The TDP-43+ group had worse performance on the BNT total score at the first (median 52 vs. 54; p=.013) and last assessment (47 vs 52; p=<.001) compared to the TDP-43- group. At the last assessment, the TDP-43+ group had a longer time to death (p=.001). At the first assessment, individuals who were TDP-43+ had an estimated 29% (95% CI 6%–56%) higher mean number of errors, after adjusting for covariates, and a 16% (95% CI 0%–34%) higher fraction of IDK responses versus correct with a phonemic cue, compared to TDP-43-. At the last assessment, TDP-43+ participants had a 30% (95% CI 5%–61%; p=.002) higher mean number of errors than those who were TDP-43- but did not show a higher fraction of IDK responses. The TDP-43 effect appeared to be greater among those with low-intermediate ADNC, however, we did not find clear evidence for a difference in TDP-43 effect in those with high ADNC versus those with low-intermediate ADNC. Conclusions: This study expands on our knowledge of the effect of TDP-43 pathology on brain function. We found that TDP-43+ individuals had a higher total number of errors at first and last assessment on the BNT, with TDP-43+ participants showing approximately one third more errors at their last assessment when controlling for ADNC. By examining responses to phonemic cues, we also found that TDP-43+ participants are more likely to experience loss of word knowledge rather than retrieval-based difficulties.

Poster

02/15/2024
04:00 pm - 05:15 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 06: Aging | MCI | Neurodegenerative Disease - PART 2

Final Abstract #72

Determinants of Confrontation Naming Deficits on the Boston Naming Test in Participants with TAR DNA-Binding Protein 43

Carling Robinson, Mayo Clini, Rochester, United States
Austin Goodrich, Mayo Clinic, Rochester, United States
Stephen Weigand, Mayo Clinic, Rochester, United States
Nha Trang Thu Pham, Mayo Clinic, Rochester, United States
Arenn Carlos, Mayo Clinic, Rochester, United States
Marina Buciuc, Medical University of South Carolina, Charleston, United States
Melissa Murray, Mayo Clinic, Jacksonville, United States
Aivi Nguyen, Mayo Clinic, Rochester, United States
R. Reichard, Mayo Clinic, Rochester, United States
David Knopman, Mayo Clinic, Rochester, United States
Ronald Petersen, Mayo Clinic, Rochester, United States
Dennis Dickson, Mayo Clinic, Jacksonville, United States
Rene Utianski, Mayo Clinic, Rochester, United States
Jennifer Whitwell, Mayo Clinic, Rochester, United States
Keith Josephs, Mayo Clinic, Rochester, United States
Mary Machulda, Mayo Clinic, Rochester, United States

Category: Neurodegenerative Disorders

Keyword 1: naming

Objective:

To examine performance on the Boston Naming Test (BNT) in individuals with Alzheimer’s disease neuropathologic changes (ADNC) who are TAR DNA-binding protein of 43 kDa positive (TDP-43+). We hypothesized that TDP-43+ participants would benefit less from phonemic cues, thus suggesting a loss of word knowledge rather than retrieval-based difficulties.

Participants and Methods:

We performed a retrospective clinicopathologic study on 282 participants with ADNC and known TDP-43 status. We evaluated item-level performance in response to phonemic cues on the 60-item BNT for first and last available assessments. We fit cross-sectional negative binomial count models that assessed (1) total number of BNT errors; and (2) number correct with phonemic cue (i.e., retrieval-based deficit) versus “I don’t know” (IDK) responses (i.e., interpreted as loss of word knowledge) at the first and last assessments. Models included TDP-43 status and adjusted for sex, age at the time of BNT test, years of education, years from the test to death, and ADNC rating. A sensitivity analysis stratified by high vs low-intermediate ADNC was also performed. For models that evaluated the last assessment, we adjusted for number of prior exposures to the BNT.

Results:

Of the 282 participants, 42.5% were TDP-43+ and 57.5% were TDP-43-. Median ages at baseline were similar (81 years and 82 years, respectively; p =.62), but the TDP-43+ group had a trend for a higher fraction of women (58% vs. 48%; p=.07). The TDP-43+ group had more APOE e4 carriers (40% vs 28%; p=.036) and a longer time from baseline to death (median 8.4 years vs. 6.1 years; p=.001) compared to the TDP-43- group. The TDP-43+ group had worse performance on the BNT total score at the first (median 52 vs. 54; p=.013) and last assessment (47 vs 52; p=<.001) compared to the TDP-43- group. At the last assessment, the TDP-43+ group had a longer time to death (p=.001). At the first assessment, individuals who were TDP-43+ had an estimated 29% (95% CI 6%–56%) higher mean number of errors, after adjusting for covariates, and a 16% (95% CI 0%–34%) higher fraction of IDK responses versus correct with a phonemic cue, compared to TDP-43-. At the last assessment, TDP-43+ participants had a 30% (95% CI 5%–61%; p=.002) higher mean number of errors than those who were TDP-43- but did not show a higher fraction of IDK responses. The TDP-43 effect appeared to be greater among those with low-intermediate ADNC, however, we did not find clear evidence for a difference in TDP-43 effect in those with high ADNC versus those with low-intermediate ADNC.

Conclusions:

This study expands on our knowledge of the effect of TDP-43 pathology on brain function. We found that TDP-43+ individuals had a higher total number of errors at first and last assessment on the BNT, with TDP-43+ participants showing approximately one third more errors at their last assessment when controlling for ADNC. By examining responses to phonemic cues, we also found that TDP-43+ participants are more likely to experience loss of word knowledge rather than retrieval-based difficulties.