INS NYC 2024 Program

Poster	Poster Session 06 Program Schedule 02/15/2024 04:00 pm - 05:15 pm Room: Shubert Complex (Posters 1-60) Poster Session 06: Aging \| MCI \| Neurodegenerative Disease - PART 2 Final Abstract #46 Exploring the Relationship of White Matter Hyperintensities with Subjective Cognitive Decline and Financial Management Among Cognitively Normal Older Adults Christopher Gonzalez, Rosalind Franklin University of Medicine and Sciences, Chicago, United States Janna Guilfoyle, Northwestern University's Feinberg School of Medicine, Chicago, United States Jared Cherry, Rosalind Franklin University of Medicine and Science, North Chicago, United States Jairo Martinez, Boston University, Boston, United States Hannah VanLandingham, Rosalind Franklin University of Medicine and Sciences, North Chicago, United States Karen Basurto, Rosalind Franklin University of Medicine and Sciences, North Chicago, United States Humza Khan, Illinois Institute of Technology, Chicago, United States Preeti Sunderaraman, Boston University Medical Campus, Boston, United States Adam Brickman, Columbia University, New York, United States Rachael Ellison, Rosalind Franklin University of Medicine and Sciences, North Chicago, United States Silvia Chapman, Columbia University, New York, United States Category: Aging Keyword 1: activities of daily living Keyword 2: neuroimaging: structural Keyword 3: memory complaints Objective: Cerebrovascular disease markers such as white matter hyperintensities (WMHs) are frequently observed in older adults and can increase the risk for cognitive impairment as well as Alzheimer’s disease and related dementia (ADRD). However, few studies examine the association of WMH and subtle cognitive and functional difficulties in cognitively unimpaired older adults. Older adults can present with subtle difficulties in cognitive functioning in the form of subjective cognitive decline (SCD) and in their instrumental activities of daily living (e.g., managing finances). Therefore, this study examined whether increased WMH volume is associated with SCD and financial management among cognitively unimpaired older adults. Participants and Methods: Data from 465 cognitively healthy older adults in the Alzheimer’s disease Neuroimaging Initiative 3 (ADNI-3) study were included. The sample was 57% female with a M_age=74.86 years (SD=7.91) and M_education=16.77 years (SD=2.38). The Financial Capacity Instrument-Short Form (FCI-SF), consisting of 38 objective items, was used to measure financial management. SCD was assessed via the Everyday Cognition (ECog) questionnaire, a 39-item subjective questionnaire where participants rate the frequency and difficulty of cognitive experiences across various domains. Small vessel cerebrovascular disease was operationalized as total white matter hyperintensity (WMH) volumes derived from T2-weighted fluid-attenuated inversion recovery (FLAIR) images. Two separate linear regression models examined the association of WMH volume with SCD and FCI-SF. Analyses included age, sex, and education as covariates. Results: Increased WMH volume was associated with decreased financial management ability (β =-.220, p<.001), and the overall model accounted for 14% of the variance, with older age (β =-.117, p<.001) and lower education attainment (β =.683, p<.001) associated with worse performance on the FCI. In addition, increased WMH volume was associated with higher levels of SCD (β =.007, p<.05), and the overall model accounted for 3% of the variance with lower education attainment being associated with higher scores on the ECog measure (β =-.029, p<.001). Conclusions: Although these results are cross-sectional, findings suggest that WMH volume may play a critical role in the development of subtle cognitive and functional difficulties in older adults. In addition, WMH was associated more strongly with FCI than SCD. Future longitudinal studies should examine whether these brain-behavior patterns reflect an early manifestation of neurodegenerative disease.

Poster

02/15/2024
04:00 pm - 05:15 pm
Room: Shubert Complex (Posters 1-60)

Poster Session 06: Aging | MCI | Neurodegenerative Disease - PART 2

Final Abstract #46

Exploring the Relationship of White Matter Hyperintensities with Subjective Cognitive Decline and Financial Management Among Cognitively Normal Older Adults

Christopher Gonzalez, Rosalind Franklin University of Medicine and Sciences, Chicago, United States
Janna Guilfoyle, Northwestern University's Feinberg School of Medicine, Chicago, United States
Jared Cherry, Rosalind Franklin University of Medicine and Science, North Chicago, United States
Jairo Martinez, Boston University, Boston, United States
Hannah VanLandingham, Rosalind Franklin University of Medicine and Sciences, North Chicago, United States
Karen Basurto, Rosalind Franklin University of Medicine and Sciences, North Chicago, United States
Humza Khan, Illinois Institute of Technology, Chicago, United States
Preeti Sunderaraman, Boston University Medical Campus, Boston, United States
Adam Brickman, Columbia University, New York, United States
Rachael Ellison, Rosalind Franklin University of Medicine and Sciences, North Chicago, United States
Silvia Chapman, Columbia University, New York, United States

Category: Aging

Keyword 1: activities of daily living
Keyword 2: neuroimaging: structural
Keyword 3: memory complaints

Objective:

Cerebrovascular disease markers such as white matter hyperintensities (WMHs) are frequently observed in older adults and can increase the risk for cognitive impairment as well as Alzheimer’s disease and related dementia (ADRD). However, few studies examine the association of WMH and subtle cognitive and functional difficulties in cognitively unimpaired older adults. Older adults can present with subtle difficulties in cognitive functioning in the form of subjective cognitive decline (SCD) and in their instrumental activities of daily living (e.g., managing finances). Therefore, this study examined whether increased WMH volume is associated with SCD and financial management among cognitively unimpaired older adults.

Participants and Methods:

Data from 465 cognitively healthy older adults in the Alzheimer’s disease Neuroimaging Initiative 3 (ADNI-3) study were included. The sample was 57% female with a M_age=74.86 years (SD=7.91) and M_education=16.77 years (SD=2.38). The Financial Capacity Instrument-Short Form (FCI-SF), consisting of 38 objective items, was used to measure financial management. SCD was assessed via the Everyday Cognition (ECog) questionnaire, a 39-item subjective questionnaire where participants rate the frequency and difficulty of cognitive experiences across various domains. Small vessel cerebrovascular disease was operationalized as total white matter hyperintensity (WMH) volumes derived from T2-weighted fluid-attenuated inversion recovery (FLAIR) images. Two separate linear regression models examined the association of WMH volume with SCD and FCI-SF. Analyses included age, sex, and education as covariates.

Results:

Increased WMH volume was associated with decreased financial management ability (β =-.220, p<.001), and the overall model accounted for 14% of the variance, with older age (β =-.117, p<.001) and lower education attainment (β =.683, p<.001) associated with worse performance on the FCI. In addition, increased WMH volume was associated with higher levels of SCD (β =.007, p<.05), and the overall model accounted for 3% of the variance with lower education attainment being associated with higher scores on the ECog measure (β =-.029, p<.001).

Conclusions:

Although these results are cross-sectional, findings suggest that WMH volume may play a critical role in the development of subtle cognitive and functional difficulties in older adults. In addition, WMH was associated more strongly with FCI than SCD. Future longitudinal studies should examine whether these brain-behavior patterns reflect an early manifestation of neurodegenerative disease.