| Poster | Poster Session 06 Program Schedule
02/15/2024
04:00 pm - 05:15 pm
Room: Shubert Complex (Posters 1-60)
Poster Session 06: Aging | MCI | Neurodegenerative Disease - PART 2
Final Abstract #45
Bouts of sedentary behavior over 20 minutes are associated with neurodegeneration and worse cognition in older adults over a 7-year follow-up period
Marissa Gogniat, University of Pittsburgh School of Medicine, Pittsburgh, United States
Brina Ratangee, Vanderbilt Memory and Alzheimer's Center, Nashville, United States
Omair Khan, Vanderbilt Memory and Alzheimer's Center, Nashville, United States
Judy Li, Vanderbilt Memory and Alzheimer's Center, Nashville, United States
Chorong Park, Vanderbilt University, School of Nursing, Nashville, United States
Kimberly Pechman, Vanderbilt Memory and Alzheimer's Center, Nashville, United States
Dandan Liu, Vanderbilt Memory and Alzheimer's Center, Nashville, United States
Bennett Landman, Vanderbilt University, Nashville, United States
Corey Bolton, Vanderbilt Memory and Alzheimer's Center, Nashville, United States
Katherine Gifford, Vanderbilt Memory and Alzheimer's Center, Nashville, United States
Timothy Hohman, Vanderbilt Memory and Alzheimer's Center, Nashville, United States
Kelsie Full, Vanderbilt University Medical Center, Division of Epidemiology, Nashville, United States
Angela Jefferson, Vanderbilt Memory and Alzheimer's Center, Nashville, United States
Category: Aging
Keyword 1: neuropsychological assessment
Keyword 2: aging disorders
Keyword 3: movement
Objective:
Sedentary behavior is a highly prevalent and modifiable risk factor for poor health outcomes in older adulthood, and modification may be preventative for Alzheimer’s disease (AD). Less is known about how the duration of sedentary behavior influences brain health and cognition over time, which has important clinical implications.
Participants and Methods:
Vanderbilt Memory and Aging Project participants (n=265, 74±8 years, 37% female) completed at least 7 days of wrist actigraphy, neuropsychological assessment, and 3T brain MRI serially over a 7-year follow-up period (mean follow-up time=4.1 years). Linear mixed effects regression analyses related average daily number of sedentary behavior bouts lasting at least 20+ minutes and at least 30+ minutes to brain structure and cognition, adjusting for age, sex, race/ethnicity, education, modified Framingham Stroke Risk Profile score, apolipoprotein E-e4 status, and cognitive status.
Results:
Participants spent an average of 13.8 hours per day sedentary, with 11.6 hours per day in sedentary bouts lasting at least 20 minutes. Bouts of sedentary behavior lasting an average of 20 minutes or more per day were associated with hippocampal atrophy (β=-0.081, p=0.02) and worse episodic memory performance (β=-0.0001, p=0.03), executive function (β=-0.0001, p=0.03), naming (β=-0.001, p=0.01), and processing speed (β=-0.002, p=0.03) over the follow-up period. Average time spent in bouts of sedentary behavior lasting at least 30 minutes was not associated with any cognitive or brain health outcomes over the follow-up periods.
Conclusions:
Among community-dwelling older adults, average time spent in sedentary bouts lasting at least 20 minutes was associated with hippocampal shrinkage and worse cognitive functioning over a 7-year follow-up period. These results suggest that the frequency of being sedentary for at least 20 minutes at a time has negative implications for brain health and cognition. While replication is needed, these results suggest that prolonged periods of being sedentary greater than 20 minutes confer risk for neurodegeneration and cognitive decline in domains impacted by AD.
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