INS NYC 2024 Program

Poster	Poster Session 06 Program Schedule 02/15/2024 04:00 pm - 05:15 pm Room: Shubert Complex (Posters 1-60) Poster Session 06: Aging \| MCI \| Neurodegenerative Disease - PART 2 Final Abstract #37 Insulin Resistance Exhibits Sex-Specific Prognostication of Memory Decline in Cognitively Unimpaired Older Adults Valentina Diaz, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States Miwa Tucker, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States Lana Callies, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States Savannah Hallgarth, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States Coty Chen, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States Caitlin Wei-Ming Watson, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States Emily Paolillo, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States Kaitlin Casaletto, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States Joel Kramer, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States Rowan Saloner, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States Category: Aging Keyword 1: aging (normal) Keyword 2: diabetes Keyword 3: memory disorders Objective: Insulin resistance is an established risk factor for Alzheimer’s disease (AD) and adverse cognitive aging, including memory decline. Prior work suggests a stronger link between insulin dysregulation, including diabetes, and AD-related outcomes in females compared to males; however, the role of insulin resistance and sex differences in longitudinal memory trajectories in non-diabetic and cognitively unimpaired older adults is less understood. The present study examined how sex differences in verbal and visual memory trajectories are influenced by markers of subclinical insulin resistance. Participants and Methods: Participants were 171 non-diabetic functionally intact (Clinical Dementia Rating = 0; mean [range] age: 72 [53-94], 51% female, mean education=17.9 years) adults enrolled in the UCSF Brain Aging Network for Cognitive Health (BrANCH). Participants had at least 3 longitudinal fasting blood draws (maximum=7) and neuropsychological assessments (maximum 10; average [max] years of follow-up= 7.8 [14.4]). Serum samples were measured for glucose and insulin, which were used to calculate mean and variability (SD) of Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) across the study period. Verbal and visual memory were quantified by CVLT-II long-delay free recall and Benson Figure free recall, respectively. Linear mixed-effects models examined sex differences in the relationship between HOMA-IR (mean and SD) and memory trajectories, adjusting for baseline age, education, and APOE-e4 status. Person-specific random intercepts and random effects of time were modeled. Results: Males and females did not differ on mean or SD HOMA-IR (ps>.10). Sex differences in memory were observed on average across the entire study period (verbal: female>male, p<.001; visual: male>female; p=.03), yet males and females did not differ on rates of memory change (ps>.10). In primary analyses, sex significantly moderated the effect of mean HOMA-IR on verbal memory (sex x mean HOMA-IR x time: b=-0.14, p=.02) such that higher mean HOMA-IR predicted steeper verbal memory decline in females (β=-0.10, p=.04), but not males (β=0.04, p=.33). In contrast, sex significantly moderated the effect of SD HOMA-IR on visual memory (sex x SD HOMA-IR x time: b=-0.18, p=.01) such that higher SD HOMA-IR predicted steeper visual memory decline in males (β=-0.10, p=.04), but not females (β=0.04, p=.33). Conclusions: Insulin resistance exhibited sex-specific effects on memory decline in typically-aging older adults. Higher insulin resistance disproportionately impacted female verbal memory trajectories, whereas higher fluctuations in insulin resistance disproportionately impacted male visual memory trajectories. These data provide evidence of sex-specific pathways by which insulin dysregulation impacts memory. These data converge with prior studies showing sex differences in insulin-related health outcomes. Future work incorporating multiple metabolic and imaging markers could further elucidate how subclinical insulin resistance, including overall burden and fluctuations, impact brain and cognitive aging.

Poster

02/15/2024
04:00 pm - 05:15 pm
Room: Shubert Complex (Posters 1-60)

Poster Session 06: Aging | MCI | Neurodegenerative Disease - PART 2

Final Abstract #37

Insulin Resistance Exhibits Sex-Specific Prognostication of Memory Decline in Cognitively Unimpaired Older Adults

Valentina Diaz, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States
Miwa Tucker, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States
Lana Callies, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States
Savannah Hallgarth, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States
Coty Chen, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States
Caitlin Wei-Ming Watson, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States
Emily Paolillo, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States
Kaitlin Casaletto, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States
Joel Kramer, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States
Rowan Saloner, Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States

Category: Aging

Keyword 1: aging (normal)
Keyword 2: diabetes
Keyword 3: memory disorders

Objective:

Insulin resistance is an established risk factor for Alzheimer’s disease (AD) and adverse cognitive aging, including memory decline. Prior work suggests a stronger link between insulin dysregulation, including diabetes, and AD-related outcomes in females compared to males; however, the role of insulin resistance and sex differences in longitudinal memory trajectories in non-diabetic and cognitively unimpaired older adults is less understood. The present study examined how sex differences in verbal and visual memory trajectories are influenced by markers of subclinical insulin resistance.

Participants and Methods:

Participants were 171 non-diabetic functionally intact (Clinical Dementia Rating = 0; mean [range] age: 72 [53-94], 51% female, mean education=17.9 years) adults enrolled in the UCSF Brain Aging Network for Cognitive Health (BrANCH). Participants had at least 3 longitudinal fasting blood draws (maximum=7) and neuropsychological assessments (maximum 10; average [max] years of follow-up= 7.8 [14.4]). Serum samples were measured for glucose and insulin, which were used to calculate mean and variability (SD) of Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) across the study period. Verbal and visual memory were quantified by CVLT-II long-delay free recall and Benson Figure free recall, respectively. Linear mixed-effects models examined sex differences in the relationship between HOMA-IR (mean and SD) and memory trajectories, adjusting for baseline age, education, and APOE-e4 status. Person-specific random intercepts and random effects of time were modeled.

Results:

Males and females did not differ on mean or SD HOMA-IR (ps>.10). Sex differences in memory were observed on average across the entire study period (verbal: female>male, p<.001; visual: male>female; p=.03), yet males and females did not differ on rates of memory change (ps>.10). In primary analyses, sex significantly moderated the effect of mean HOMA-IR on verbal memory (sex x mean HOMA-IR x time: b=-0.14, p=.02) such that higher mean HOMA-IR predicted steeper verbal memory decline in females (β=-0.10, p=.04), but not males (β=0.04, p=.33). In contrast, sex significantly moderated the effect of SD HOMA-IR on visual memory (sex x SD HOMA-IR x time: b=-0.18, p=.01) such that higher SD HOMA-IR predicted steeper visual memory decline in males (β=-0.10, p=.04), but not females (β=0.04, p=.33).

Conclusions:

Insulin resistance exhibited sex-specific effects on memory decline in typically-aging older adults. Higher insulin resistance disproportionately impacted female verbal memory trajectories, whereas higher fluctuations in insulin resistance disproportionately impacted male visual memory trajectories. These data provide evidence of sex-specific pathways by which insulin dysregulation impacts memory. These data converge with prior studies showing sex differences in insulin-related health outcomes. Future work incorporating multiple metabolic and imaging markers could further elucidate how subclinical insulin resistance, including overall burden and fluctuations, impact brain and cognitive aging.