INS NYC 2024 Program

Poster	Poster Session 06 Program Schedule 02/15/2024 04:00 pm - 05:15 pm Room: Shubert Complex (Posters 1-60) Poster Session 06: Aging \| MCI \| Neurodegenerative Disease - PART 2 Final Abstract #35 Comparing Neural Correlates of Object-Location Associations in Healthy Aging and Alzheimer's Disease: A Multi-Modal Approach Victor Di Rita, Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, United States Anthony Moceri, Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, United States Jordyn Herrington, Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, United States Megan Schumer, Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, United States Annalise Rahman-Filipiak, Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, United States Alexandre DaSilva, Headache and Orofacial Pain Effort Laboratory, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan, Ann Arbor, United States Benjamin Hampstead, Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, United States Alexandru Iordan, Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, United States Category: Neuroimaging Keyword 1: dementia - Alzheimer's disease Objective: Amnestic mild cognitive impairment (aMCI), a precursor to Alzheimer's-type dementia (DAT), is characterized by associative memory deficits, such as difficulty recalling object-location placements. Detecting these difficulties and their corresponding neural signatures early is crucial for devising effective interventions. Although functional magnetic resonance imaging (fMRI) is the established benchmark for investigating brain activity, its limitations, including discomfort, metal implant constraints, and high expenses, warrant the exploration of alternative methods. Functional near-infrared spectroscopy (fNIRS) offers a more comfortable, cost-effective, and adaptable solution. Nevertheless, the degree of correspondence between fNIRS and fMRI-based activations remains uncertain. Therefore, we compared the patterns of activation observed during object-location association encoding using both fMRI and fNIRS in cognitively intact older adults (CIOA) and individuals with amnestic mild cognitive impairment (aMCI) or dementia of the Alzheimer’s type (DAT). Participants and Methods: Thirty-eight CIOA (19 females), 12 participants with aMCI (2 females), and 13 participants with DAT (8 females) completed fNIRS and fMRI sessions that were counterbalanced and performed on separate days. During each session, participants performed an object-location association (OLA) memory task in which they were asked to remember novel objects placed in plausible locations within rooms in a virtual house (“Novel” OLA). A control condition presented two object-locations repeatedly (“Repeated” OLA) to control for perceptual effects. Our fNIRS probe consisted of 107 long channels and 8 fixed-distance short channels, providing full-brain coverage. We acquired fNIRS data using two continuous-wave NIRSport2 devices and used the Brain AnalyzIR and EasyTopo Matlab toolboxes for pre-processing, analysis, and visualization. Whole-brain fMRI volumes were also acquired and preprocessed using SPM12 following typical steps: slice-timing, realignment, coregistration, and normalization. fMRI analyses were performed using SPM12. Results: Overall, fMRI and fNIRS results were partially congruent, with fMRI typically showing more extensive brain activation. CIOA showed consistent activation of prefrontal, parieto-occipital, and occipital regions during the encoding of novel versus repeated OLAs, across both fMRI and fNIRS modalities. Relative to CIOA, those with memory deficits (i.e., aMCI and DAT together) showed lower activation in the left posterior dorsolateral frontal cortex when encoding novel versus repeated OLAs across both imaging modalities. Finally, within the memory-impaired group, individuals with aMCI showed greater activation in the right lateral prefrontal cortex for novel versus repeated OLAs, relative to those with DAT, across both imaging modalities. Conclusions: The partially congruent patterns of brain activation across the two modalities during novel OLA encoding suggest that fNIRS may be a viable alternative for those unable to undergo fMRI. In addition, the reduced activation of the left posterior dorsolateral frontal cortex during the encoding of novel OLAs in the combined memory impaired group suggests a common neural signature of encoding impairment across modalities. Finally, greater activation in the right lateral prefrontal in aMCI relative to DAT, regardless of imaging modality, suggests potential functional preservation in the early stages of cognitive decline.

Poster

02/15/2024
04:00 pm - 05:15 pm
Room: Shubert Complex (Posters 1-60)

Poster Session 06: Aging | MCI | Neurodegenerative Disease - PART 2

Final Abstract #35

Comparing Neural Correlates of Object-Location Associations in Healthy Aging and Alzheimer's Disease: A Multi-Modal Approach

Victor Di Rita, Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, United States
Anthony Moceri, Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, United States
Jordyn Herrington, Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, United States
Megan Schumer, Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, United States
Annalise Rahman-Filipiak, Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, United States
Alexandre DaSilva, Headache and Orofacial Pain Effort Laboratory, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan, Ann Arbor, United States
Benjamin Hampstead, Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, United States
Alexandru Iordan, Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, United States

Category: Neuroimaging

Keyword 1: dementia - Alzheimer's disease

Objective:

Amnestic mild cognitive impairment (aMCI), a precursor to Alzheimer's-type dementia (DAT), is characterized by associative memory deficits, such as difficulty recalling object-location placements. Detecting these difficulties and their corresponding neural signatures early is crucial for devising effective interventions. Although functional magnetic resonance imaging (fMRI) is the established benchmark for investigating brain activity, its limitations, including discomfort, metal implant constraints, and high expenses, warrant the exploration of alternative methods. Functional near-infrared spectroscopy (fNIRS) offers a more comfortable, cost-effective, and adaptable solution. Nevertheless, the degree of correspondence between fNIRS and fMRI-based activations remains uncertain. Therefore, we compared the patterns of activation observed during object-location association encoding using both fMRI and fNIRS in cognitively intact older adults (CIOA) and individuals with amnestic mild cognitive impairment (aMCI) or dementia of the Alzheimer’s type (DAT).

Participants and Methods:

Thirty-eight CIOA (19 females), 12 participants with aMCI (2 females), and 13 participants with DAT (8 females) completed fNIRS and fMRI sessions that were counterbalanced and performed on separate days. During each session, participants performed an object-location association (OLA) memory task in which they were asked to remember novel objects placed in plausible locations within rooms in a virtual house (“Novel” OLA). A control condition presented two object-locations repeatedly (“Repeated” OLA) to control for perceptual effects. Our fNIRS probe consisted of 107 long channels and 8 fixed-distance short channels, providing full-brain coverage. We acquired fNIRS data using two continuous-wave NIRSport2 devices and used the Brain AnalyzIR and EasyTopo Matlab toolboxes for pre-processing, analysis, and visualization. Whole-brain fMRI volumes were also acquired and preprocessed using SPM12 following typical steps: slice-timing, realignment, coregistration, and normalization. fMRI analyses were performed using SPM12.

Results:

Overall, fMRI and fNIRS results were partially congruent, with fMRI typically showing more extensive brain activation. CIOA showed consistent activation of prefrontal, parieto-occipital, and occipital regions during the encoding of novel versus repeated OLAs, across both fMRI and fNIRS modalities. Relative to CIOA, those with memory deficits (i.e., aMCI and DAT together) showed lower activation in the left posterior dorsolateral frontal cortex when encoding novel versus repeated OLAs across both imaging modalities. Finally, within the memory-impaired group, individuals with aMCI showed greater activation in the right lateral prefrontal cortex for novel versus repeated OLAs, relative to those with DAT, across both imaging modalities.

Conclusions:

The partially congruent patterns of brain activation across the two modalities during novel OLA encoding suggest that fNIRS may be a viable alternative for those unable to undergo fMRI. In addition, the reduced activation of the left posterior dorsolateral frontal cortex during the encoding of novel OLAs in the combined memory impaired group suggests a common neural signature of encoding impairment across modalities. Finally, greater activation in the right lateral prefrontal in aMCI relative to DAT, regardless of imaging modality, suggests potential functional preservation in the early stages of cognitive decline.