| Poster | Poster Session 06 Program Schedule
02/15/2024
04:00 pm - 05:15 pm
Room: Shubert Complex (Posters 1-60)
Poster Session 06: Aging | MCI | Neurodegenerative Disease - PART 2
Final Abstract #31
Purpose in Life and Brain Health in Older Adults
Jeanyung Chey, Seoul National University, Seoul, Korea, Republic of
Sung-Ha Lee, Seoul National University, Seoul, Korea, Republic of
Hyunjeong Kwak, Seoul National University, Seoul, Korea, Republic of
Undrakh Tuguldur, Seoul National University, Seoul, Korea, Republic of
Category: Aging
Keyword 1: quality of life
Keyword 2: brain function
Keyword 3: cognitive functioning
Objective:
Psychological well-being (PWB) have been associated with various health outcomes (Fredrickson et al., 2015), including cardiovascular function (Cohen, 2016) and risk of dementia (Wilson et al., 2013). The pathways or mechanism underlying the association between PWB and cognitive or brain aging, however, have been elusive. In this presentation, we explore possible pathways or mechanisms underlying the association focused on purpose in life (PIL) in older adults.
Participants and Methods:
A battery of neuropsychological, PSW, structural/functional brain imaging data of 126 participants were obtained from the Korean Social, Health and Aging Project (KSHAP). To investigate the neural mechanism underlying between PIL and brain aging, we first analyzed the total and regional brain volumes obtained from the T1 MR images, WMH from the T2 flair images and examined its association with the PIL subscale of the Ryff’s Psychological Well-Being (1989, 2014) survey, controlling age, sex, education and intracranial cavity volume(ICV). Further we investigated the moderating effects of PIL (W) between the volumetric measures’(M) mediation of age (X) effects on cognitive performance (Y). Statistical analyses were conducted using the SPSS 23 and PROCESS macro 4.2.
Results:
We found increased grey matter volumes associated with higher scores on PIL, when controlled for age, sex, education and ICV. We also found evidences suggesting regional volumes mediated the effects of age on cognitive performance in some domains, such as memory, which was further moderated by PIL. More detailed results will be presented at the meeting.
Conclusions:
In this study, older adults who reported greater sense of purpose in life demonstrated significantly greater brain volume in older adults, suggestive of better brain health. Further, PIL appear to moderate the mediating effects of brain volumes between age and cognitive performance. The benefits of having greater purpose in life in terms of brain and cognitive health in older adults are discussed.
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