INS NYC 2024 Program

Poster	Poster Session 06 Program Schedule 02/15/2024 04:00 pm - 05:15 pm Room: Shubert Complex (Posters 1-60) Poster Session 06: Aging \| MCI \| Neurodegenerative Disease - PART 2 Final Abstract #28 DRD3 Predicts Cognitive Impairment in Parkinson’s Disease: Susceptibility Effects Alexandra Gonçalves, Centro Hospitalar Universitário de Santo António, Porto, Portugal Alexandre Mendes, Centro Hospitalar Universitário de Santo António, Porto, Portugal Nuno Vila-Chã, Centro Hospitalar Universitário de Santo António, Porto, Portugal Joana Damásio, Centro Hospitalar Universitário de Santo António, Porto, Portugal Daniela Boleixa, Instituto Ciências Biomédicas Abel Salazar, Porto, Portugal Bárbara Leal, Instituto Ciências Biomédicas Abel Salazar, Porto, Portugal Sara Cavaco, Centro Hospitalar Universitário de Santo António, Porto, Portugal Category: Movement and Movement Disorders Keyword 1: Parkinson's disease Keyword 2: genetics Objective: A possible genetic contribution of dopamine D3 receptor (DRD3) to cognitive impairment in Parkinson’s disease (PD) has yet to be investigated. The aim of this study was to explore the effects of rs6280 (Ser9Gly) genotype on PD patients’ cognitive performance. Participants and Methods: Two hundred and fifty-three consecutive PD patients underwent neurological and neuropsychological evaluations, which included: Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn & Yahr scale (H&Y), Dementia Rating Scale-2 (DRS-2) and Hospital Anxiety and Depression Scale (HADS). rs6280 polymorphism was genotyped for all PD patients and for 270 ethnically matched healthy volunteers (HC). Non-parametric group comparisons and logistic regressions were used for data analyses. Results: rs6280 genotype did not differ between PD and HC groups. PD patients with rs6280 CC genotype had more impaired cognitive performance (i.e., <1^st percentile of demographically adjusted norms) on DRS-2 subscales Initiation/Perseveration (p=0.004) and Construction (p<0.001) than those with TT genotype. These associations remained statistically significant when other covariates (e.g., demographic features, disease duration, severity of motor symptoms in OFF and ON states, anti-parkinsonian medication, and psychopathology symptoms) were taken into consideration. Conclusions: Study findings suggest that rs6280 is not a genotypic susceptibility factor for PD. Though, the presence of two C alleles predisposes to executive dysfunction and visuoconstructional deficits.

Poster

02/15/2024
04:00 pm - 05:15 pm
Room: Shubert Complex (Posters 1-60)

Poster Session 06: Aging | MCI | Neurodegenerative Disease - PART 2

Final Abstract #28

DRD3 Predicts Cognitive Impairment in Parkinson’s Disease: Susceptibility Effects

Alexandra Gonçalves, Centro Hospitalar Universitário de Santo António, Porto, Portugal
Alexandre Mendes, Centro Hospitalar Universitário de Santo António, Porto, Portugal
Nuno Vila-Chã, Centro Hospitalar Universitário de Santo António, Porto, Portugal
Joana Damásio, Centro Hospitalar Universitário de Santo António, Porto, Portugal
Daniela Boleixa, Instituto Ciências Biomédicas Abel Salazar, Porto, Portugal
Bárbara Leal, Instituto Ciências Biomédicas Abel Salazar, Porto, Portugal
Sara Cavaco, Centro Hospitalar Universitário de Santo António, Porto, Portugal

Category: Movement and Movement Disorders

Keyword 1: Parkinson's disease
Keyword 2: genetics

Objective:

A possible genetic contribution of dopamine D3 receptor (DRD3) to cognitive impairment in Parkinson’s disease (PD) has yet to be investigated. The aim of this study was to explore the effects of rs6280 (Ser9Gly) genotype on PD patients’ cognitive performance.

Participants and Methods:

Two hundred and fifty-three consecutive PD patients underwent neurological and neuropsychological evaluations, which included: Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn & Yahr scale (H&Y), Dementia Rating Scale-2 (DRS-2) and Hospital Anxiety and Depression Scale (HADS). rs6280 polymorphism was genotyped for all PD patients and for 270 ethnically matched healthy volunteers (HC). Non-parametric group comparisons and logistic regressions were used for data analyses.

Results:

rs6280 genotype did not differ between PD and HC groups. PD patients with rs6280 CC genotype had more impaired cognitive performance (i.e., <1^st percentile of demographically adjusted norms) on DRS-2 subscales Initiation/Perseveration (p=0.004) and Construction (p<0.001) than those with TT genotype. These associations remained statistically significant when other covariates (e.g., demographic features, disease duration, severity of motor symptoms in OFF and ON states, anti-parkinsonian medication, and psychopathology symptoms) were taken into consideration.

Conclusions:

Study findings suggest that rs6280 is not a genotypic susceptibility factor for PD. Though, the presence of two C alleles predisposes to executive dysfunction and visuoconstructional deficits.