INS NYC 2024 Program

Poster	Poster Session 05 Program Schedule 02/15/2024 02:30 pm - 03:45 pm Room: Majestic Complex (Posters 61-120) Poster Session 05: Neuropsychiatry \| Addiction/Dependence \| Stress/Coping \| Emotional/Social Processes Final Abstract #96 Subjective, but not Objective, Measures Differ between Remitted Late-Life Depression and Age-Matched Controls Sarah Szymkowicz, Vanderbilt University Medical Center, Nashville, United States Meryl Butters, University of Pittsburgh Medical Center, Pittsburgh, United States Olusola Ajilore, University of Illinois Chicago, Chicago, United States Carmen Andreescu, University of Pittsburgh Medical Center, Pittsburgh, United States Warren Taylor, Vanderbilt University Medical Center, Nashville, United States Category: Mood and Anxiety Disorders Keyword 1: depression Keyword 2: cognitive functioning Keyword 3: neuroimaging: structural Objective: Remitted late-life depression (rLLD) is associated with negative outcomes that persist after remission, including neurobiological (e.g., decreased hippocampal volume, higher white matter hyperintensities burden) and cognitive outcomes (e.g., memory and executive impairment). There has been recent interest in the role that resilience plays in LLD outcomes and the current study focused on relationships between resilience and demographic, medical, cognitive, and neurobiological factors in rLLD and age-matched control participants. Participants and Methods: Non-demented individuals with rLLD (n = 99, mean age = 66.61±4.18 years, 68% female, 89% Caucasian, mean MADRS = 5.35±3.30, mean MoCA = 26.13±2.00) and control participants (n = 49, mean age = 66.76±5.11 years, 57% female, 78% Caucasian, mean MADRS = 0.98±1.44, mean MoCA = 26.24±1.41) were recruited for a multi-site study investigating factors that predict LLD recurrence risk. Individuals with LLD were treated to remission (defined as MADRS < 10) before beginning study procedures. Baseline demographic and clinical characteristics were collected and participants completed a standard neuropsychological battery and 3T neuroimaging. Resilience was measured with the Connor-Davidson Resilience Scale-10 (CD-RISC-10), medical burden with the Cumulative Illness Rating Scale-Geriatrics (CIRS-G), perceived disability with the WHO Disability Assessment Schedule (WHODAS), and subjective cognitive complaints with the Everyday Cognition Scale-12 (ECog-12). Raw scores from the three immediate and delayed recall memory tests on the RBANS were converted to age-adjusted z-scores based on the manual and Immediate Memory and Delayed Recall composites were created by averaging the z-scores within the domain. Volumes for white matter lesions (WML) and total right and left hippocampus were extracted via FreeSurfer 7. Within-group associations and unadjusted between-group differences were investigated with correlations and ANOVAs. ANCOVAs examined between group differences on the various factors and whether resilience predicted specific outcomes. Results: Differential within-group relationships with resilience were found, such that lower resilience in rLLD was associated with higher perceived disability, greater depressive symptom severity, and lower immediate memory scores, while lower resilience in control participants was only related to greater subjective cognitive complaints (p’s < 0.05). Group differences were identified in education, medical burden, and subjective scales, such that rLLD had lower education (p < 0.05), greater medical burden, and higher / worse ratings on the MADRS, CD-RISC-10, WHODAS, and ECog-12 (all p’s < 0.001). There were no group differences in the other demographic or objective measures (MoCA, Immediate or Delayed Recall composites, WML or hippocampal volumes). After covariate adjustment, group differences remained on the CD-RISC-10, WHODAS, and ECog-12 (with current depressive symptoms not accounting for these differences; p’s < 0.05). Higher resilience did predict better scores for perceived disability and subjective cognitive ratings (p’s = 0.002 and 0.006, respectively; did not differ by condition). There were no group differences and resilience did not predict the objective cognitive or neurobiological measures. Conclusions: Despite having similar objective cognitive performances and neurobiological measures, the rLLD reported less resilience, higher perceived disability, and more subjective cognitive complaints than control participants. Higher resilience predicted lower perceived disability and better subjective cognition regardless of group; thus, resilience-building interventions may improve subjective symptoms.

Poster

02/15/2024
02:30 pm - 03:45 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 05: Neuropsychiatry | Addiction/Dependence | Stress/Coping | Emotional/Social Processes

Final Abstract #96

Subjective, but not Objective, Measures Differ between Remitted Late-Life Depression and Age-Matched Controls

Sarah Szymkowicz, Vanderbilt University Medical Center, Nashville, United States
Meryl Butters, University of Pittsburgh Medical Center, Pittsburgh, United States
Olusola Ajilore, University of Illinois Chicago, Chicago, United States
Carmen Andreescu, University of Pittsburgh Medical Center, Pittsburgh, United States
Warren Taylor, Vanderbilt University Medical Center, Nashville, United States

Category: Mood and Anxiety Disorders

Keyword 1: depression
Keyword 2: cognitive functioning
Keyword 3: neuroimaging: structural

Objective:

Remitted late-life depression (rLLD) is associated with negative outcomes that persist after remission, including neurobiological (e.g., decreased hippocampal volume, higher white matter hyperintensities burden) and cognitive outcomes (e.g., memory and executive impairment). There has been recent interest in the role that resilience plays in LLD outcomes and the current study focused on relationships between resilience and demographic, medical, cognitive, and neurobiological factors in rLLD and age-matched control participants.

Participants and Methods:

Non-demented individuals with rLLD (n = 99, mean age = 66.61±4.18 years, 68% female, 89% Caucasian, mean MADRS = 5.35±3.30, mean MoCA = 26.13±2.00) and control participants (n = 49, mean age = 66.76±5.11 years, 57% female, 78% Caucasian, mean MADRS = 0.98±1.44, mean MoCA = 26.24±1.41) were recruited for a multi-site study investigating factors that predict LLD recurrence risk. Individuals with LLD were treated to remission (defined as MADRS < 10) before beginning study procedures. Baseline demographic and clinical characteristics were collected and participants completed a standard neuropsychological battery and 3T neuroimaging. Resilience was measured with the Connor-Davidson Resilience Scale-10 (CD-RISC-10), medical burden with the Cumulative Illness Rating Scale-Geriatrics (CIRS-G), perceived disability with the WHO Disability Assessment Schedule (WHODAS), and subjective cognitive complaints with the Everyday Cognition Scale-12 (ECog-12). Raw scores from the three immediate and delayed recall memory tests on the RBANS were converted to age-adjusted z-scores based on the manual and Immediate Memory and Delayed Recall composites were created by averaging the z-scores within the domain. Volumes for white matter lesions (WML) and total right and left hippocampus were extracted via FreeSurfer 7. Within-group associations and unadjusted between-group differences were investigated with correlations and ANOVAs. ANCOVAs examined between group differences on the various factors and whether resilience predicted specific outcomes.

Results:

Differential within-group relationships with resilience were found, such that lower resilience in rLLD was associated with higher perceived disability, greater depressive symptom severity, and lower immediate memory scores, while lower resilience in control participants was only related to greater subjective cognitive complaints (p’s < 0.05). Group differences were identified in education, medical burden, and subjective scales, such that rLLD had lower education (p < 0.05), greater medical burden, and higher / worse ratings on the MADRS, CD-RISC-10, WHODAS, and ECog-12 (all p’s < 0.001). There were no group differences in the other demographic or objective measures (MoCA, Immediate or Delayed Recall composites, WML or hippocampal volumes). After covariate adjustment, group differences remained on the CD-RISC-10, WHODAS, and ECog-12 (with current depressive symptoms not accounting for these differences; p’s < 0.05). Higher resilience did predict better scores for perceived disability and subjective cognitive ratings (p’s = 0.002 and 0.006, respectively; did not differ by condition). There were no group differences and resilience did not predict the objective cognitive or neurobiological measures.

Conclusions:

Despite having similar objective cognitive performances and neurobiological measures, the rLLD reported less resilience, higher perceived disability, and more subjective cognitive complaints than control participants. Higher resilience predicted lower perceived disability and better subjective cognition regardless of group; thus, resilience-building interventions may improve subjective symptoms.