INS NYC 2024 Program

Poster	Poster Session 05 Program Schedule 02/15/2024 02:30 pm - 03:45 pm Room: Majestic Complex (Posters 61-120) Poster Session 05: Neuropsychiatry \| Addiction/Dependence \| Stress/Coping \| Emotional/Social Processes Final Abstract #84 Impulsivity, Inhibition, and Motivation in Children with Mild Traumatic Brain Injury Using True Prospective Measurement Pre- and Post-Injury Emma Read, University of Utah, Salt Lake City, United States Wenjing Meng, University of California, San Diego, La Jolla, United States Elisabeth Wilde, University of Utah, Salt Lake City, United States Emily Dennis, University of Utah, Salt Lake City, United States Joanna Jacobus, University of California, San Diego, La Jolla, United States Naomi Goodrich Hunsaker, University of Utah, Salt Lake City, United States Emily Troyer, University of California, San Diego, La Jolla, United States Tracy Abildskov, University of Utah, Salt Lake City, United States Xia Yang, University of California, Los Angeles, Los Angeles, United States Michael Cheng, University of California, Los Angeles, Los Angeles, United States Erin Bigler, Brigham Young University, Provo, United States Florin Vaida, University of California, San Diego, La Jolla, United States Jeffrey Max, University of California, San Diego, La Jolla, United States Category: Concussion/Mild TBI (Child) Keyword 1: traumatic brain injury Keyword 2: pediatric neuropsychology Keyword 3: inhibitory control Objective: Mild traumatic brain injury (mTBI) during childhood has been associated with behavioral traits, including sensation-seeking and impulsivity. However, prior studies have been limited in assessing whether these attributes develop pre- or post-TBI. The longitudinal Adolescent Brain Cognitive Development (ABCD) study provides a unique opportunity to examine behavioral measures assessed prior to injury in children that later sustain mTBI. Participants and Methods: Participants were selected from 11,866 children enrolled in the ABCD study. Our analysis included three groups: mTBI(n=98), children with no injury at baseline or year-1 who developed mTBI by their year-2 follow-up; orthopedic injury (OI,n=264) children with no injury at baseline or year-1 who developed OI by year-2; and no injury (NI,n=264), children randomly selected with no injury by year-2. We used difference-in-differences linear mixed-effects models analysis adjusting for age, sex, income, education, and race/ethnicity to compare longitudinal changes in behavioral scores (UPPS-P Impulsive Behavior Scale – parent-report impulsivity measure; Behavioral Inhibition System/Behavioral Activation System [BIS/BAS] – measure of motivation and response to threat/reward) between groups at baseline (pre-injury) and year-2 follow-up (post-injury). Results: At baseline, children in the mTBI group had higher scores on UPPS-P Sensation-Seeking (pre-injury) as compared to the uninjured group (p=0.020), reflecting greater sensation-seeking behavior. Although the OI group did not differ significantly from the mTBI group, its mean score was between the other groups. Additionally, the mTBI and NI groups differed on Positive Urgency (p=0.006), and the mTBI and OI groups marginally differed (p=0.051) showing greater impulsive behavior in the mTBI group. There were no group differences in Negative Urgency, Lack of Planning, or Lack of Perseverance. Additionally, children with mTBI demonstrated a marginally lower BIS-subscale score than children in the NI group (p=0.074) indicating lower threat-sensitivity pre-injury/baseline. No significant differences existed for any BAS-subscale score (Reward Responsivity, Drive, Fun Seeking). In longitudinal analyses for Sensation-Seeking, the group-by-time interaction was not significant; however, the mTBI group retained higher Sensation-Seeking than the other groups and didn’t increase disproportionately to the other cohorts. Similarly, there was no group-by-time interaction for Positive Urgency, Lack of Planning, or Lack of Perseverance. However, there was a significant group-by-time interaction for Negative Urgency (p=0.024) whereby there was a greater improvement over time in rash reactions to negative emotions in the NI group as compared to the mTBI group, which stayed relatively constant. There was also a marginally significant difference in change of BIS subscale score (p=0.052), between the NI group (who decreased over time reflecting increased threat-sensitivity), and mTBI group, who remained constant. Conclusions: This prospective study design allows a unique opportunity to examine whether behavioral differences in children post-injury (including impulsivity, threat-sensitivity, and motivation) can be attributed solely to injury or if preexisting behavioral traits increase injury susceptibility. Our findings suggest that injury might not be the sole cause of these behavioral differences post-mTBI; rather, some behavioral traits, such as Sensation Seeking, may predate injury — though injury may also attenuate behavioral development of traits such as Negative Urgency and threat-sensitivity. Both research and clinical practice should consider each possibility.

Poster

02/15/2024
02:30 pm - 03:45 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 05: Neuropsychiatry | Addiction/Dependence | Stress/Coping | Emotional/Social Processes

Final Abstract #84

Impulsivity, Inhibition, and Motivation in Children with Mild Traumatic Brain Injury Using True Prospective Measurement Pre- and Post-Injury

Emma Read, University of Utah, Salt Lake City, United States
Wenjing Meng, University of California, San Diego, La Jolla, United States
Elisabeth Wilde, University of Utah, Salt Lake City, United States
Emily Dennis, University of Utah, Salt Lake City, United States
Joanna Jacobus, University of California, San Diego, La Jolla, United States
Naomi Goodrich Hunsaker, University of Utah, Salt Lake City, United States
Emily Troyer, University of California, San Diego, La Jolla, United States
Tracy Abildskov, University of Utah, Salt Lake City, United States
Xia Yang, University of California, Los Angeles, Los Angeles, United States
Michael Cheng, University of California, Los Angeles, Los Angeles, United States
Erin Bigler, Brigham Young University, Provo, United States
Florin Vaida, University of California, San Diego, La Jolla, United States
Jeffrey Max, University of California, San Diego, La Jolla, United States

Category: Concussion/Mild TBI (Child)

Keyword 1: traumatic brain injury
Keyword 2: pediatric neuropsychology
Keyword 3: inhibitory control

Objective:

Mild traumatic brain injury (mTBI) during childhood has been associated with behavioral traits, including sensation-seeking and impulsivity. However, prior studies have been limited in assessing whether these attributes develop pre- or post-TBI. The longitudinal Adolescent Brain Cognitive Development (ABCD) study provides a unique opportunity to examine behavioral measures assessed prior to injury in children that later sustain mTBI.

Participants and Methods:

Participants were selected from 11,866 children enrolled in the ABCD study. Our analysis included three groups: mTBI(n=98), children with no injury at baseline or year-1 who developed mTBI by their year-2 follow-up; orthopedic injury (OI,n=264) children with no injury at baseline or year-1 who developed OI by year-2; and no injury (NI,n=264), children randomly selected with no injury by year-2. We used difference-in-differences linear mixed-effects models analysis adjusting for age, sex, income, education, and race/ethnicity to compare longitudinal changes in behavioral scores (UPPS-P Impulsive Behavior Scale – parent-report impulsivity measure; Behavioral Inhibition System/Behavioral Activation System [BIS/BAS] – measure of motivation and response to threat/reward) between groups at baseline (pre-injury) and year-2 follow-up (post-injury).

Results:

At baseline, children in the mTBI group had higher scores on UPPS-P Sensation-Seeking (pre-injury) as compared to the uninjured group (p=0.020), reflecting greater sensation-seeking behavior. Although the OI group did not differ significantly from the mTBI group, its mean score was between the other groups. Additionally, the mTBI and NI groups differed on Positive Urgency (p=0.006), and the mTBI and OI groups marginally differed (p=0.051) showing greater impulsive behavior in the mTBI group. There were no group differences in Negative Urgency, Lack of Planning, or Lack of Perseverance. Additionally, children with mTBI demonstrated a marginally lower BIS-subscale score than children in the NI group (p=0.074) indicating lower threat-sensitivity pre-injury/baseline. No significant differences existed for any BAS-subscale score (Reward Responsivity, Drive, Fun Seeking).

In longitudinal analyses for Sensation-Seeking, the group-by-time interaction was not significant; however, the mTBI group retained higher Sensation-Seeking than the other groups and didn’t increase disproportionately to the other cohorts. Similarly, there was no group-by-time interaction for Positive Urgency, Lack of Planning, or Lack of Perseverance. However, there was a significant group-by-time interaction for Negative Urgency (p=0.024) whereby there was a greater improvement over time in rash reactions to negative emotions in the NI group as compared to the mTBI group, which stayed relatively constant. There was also a marginally significant difference in change of BIS subscale score (p=0.052), between the NI group (who decreased over time reflecting increased threat-sensitivity), and mTBI group, who remained constant.

Conclusions:

This prospective study design allows a unique opportunity to examine whether behavioral differences in children post-injury (including impulsivity, threat-sensitivity, and motivation) can be attributed solely to injury or if preexisting behavioral traits increase injury susceptibility. Our findings suggest that injury might not be the sole cause of these behavioral differences post-mTBI; rather, some behavioral traits, such as Sensation Seeking, may predate injury — though injury may also attenuate behavioral development of traits such as Negative Urgency and threat-sensitivity. Both research and clinical practice should consider each possibility.