INS NYC 2024 Program

Poster	Poster Session 05 Program Schedule 02/15/2024 02:30 pm - 03:45 pm Room: Majestic Complex (Posters 61-120) Poster Session 05: Neuropsychiatry \| Addiction/Dependence \| Stress/Coping \| Emotional/Social Processes Final Abstract #71 Self-Report Anterograde and Retrograde Memory Outcomes Following Electroconvulsive Therapy in Adults with Major Depressive Disorder Tulip Marawi, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada Isabella Sewell, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada Georgia Gopinath, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada Claire Lauzon, Department of Psychology, York University, Toronto, Canada Peter Giacobbe, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada Sean Nestor, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada Stefan Köhler, Department of Psychology, University of Western Ontario, London, Canada R. Rosenbaum, Department of Psychology, Centre for Vision Research, York University, Toronto, Canada Sandra Black, Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and Sunnybrook Research Institute, University of Toronto, Toronto, Canada Maged Goubran, LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada Nir Lipsman, Division of Neurosurgery, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada Jennifer Rabin, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada Category: Psychiatric Disorders Keyword 1: depression Keyword 2: neuromodulation Keyword 3: memory complaints Objective: Electroconvulsive therapy (ECT) is widely recognized as an effective treatment for major depressive disorder (MDD). However, there are concerns regarding its effect on memory. Recent research suggests that ECT may disproportionally affect memories formed in close temporal proximity to ECT, while older memories remain unaffected. In the present study, we developed a novel self-report scale of retrograde memory to test this hypothesis. We also contrasted performance on this scale with a validated self-report measure of anterograde memory. Participants and Methods: Individuals diagnosed with unipolar or bipolar depression were tested before and approximately 1 month (mean=28.6 days) after an acute course of ECT. Healthy control participants were tested at a single time point. To assess retrograde memory, participants completed a novel self-report scale known as the Subjective Appraisal of Retrospective Memory (SARM). The SARM uses a visual analogue scale to assess the extent to which participants can vividly and confidently recall detailed events across 5 distinct life periods: the past month, 1 to 6 months, 6 to 12 months, 1 to 5 years, and 5 to 10 years. Participants also completed a published self-report measure of anterograde memory (Multifactorial Memory Questionnaire (MMQ): Memory Mistakes scale). This scale assesses self-perceived everyday memory abilities by asking participants to rate how frequently they experience each of 20 common memory mistakes over the previous 2 weeks. Memory abilities were compared between patients and controls at baseline using ANCOVA, adjusting for age and sex. ECT-related memory changes were assessed using paired t-tests. Results: The study included 17 individuals with treatment-refractory MDD (mean age: 42.3 [SD:12.5] years; 10 [58.9%] female) and 5 control participants (mean age: 44.6 [SD:20.5], 1 [20.0%] female). Compared to controls, individuals with MDD reported greater difficulty remembering past events across all time periods on the SARM (p-value range: 0.005-0.1) and endorsed more pronounced memory difficulties on the MMQ Memory Mistakes scale (F(1,16) = 6.14, p = 0.025). Regarding changes in retrograde memory due to ECT, individuals with MDD reported significantly greater difficulty remembering events from the month immediately preceding ECT treatment (t(13) = 2.2, p=0.048). However, there were no significant changes in memory recall for the other time periods on the SARM, including 1 to 6 months (t(13) = -0.0089, p =0.99), 6 to 12 months (t(13) = -0.77, p=0.46), 1 to 5 years (t(13) = -1.69, p=0.11), and 5 to 10 years ago (t(13) = -1.06, p=0.31). In terms of anterograde memory, there were no significant changes following ECT on the MMQ Memory Mistakes scale (t(13) = 1.67, p =0.12). Conclusions: Using a novel self-report scale, our findings suggest that ECT may negatively impact the recall of episodic memories formed within the month prior to treatment, while more remote memories are unchanged. In addition, self-perceived anterograde memory does not seem to be affected by ECT. Future work will examine the relationships between hippocampal morphometry and retrograde/anterograde subjective memory performance following ECT.

Poster

02/15/2024
02:30 pm - 03:45 pm
Room: Majestic Complex (Posters 61-120)

Poster Session 05: Neuropsychiatry | Addiction/Dependence | Stress/Coping | Emotional/Social Processes

Final Abstract #71

Self-Report Anterograde and Retrograde Memory Outcomes Following Electroconvulsive Therapy in Adults with Major Depressive Disorder

Tulip Marawi, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada
Isabella Sewell, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada
Georgia Gopinath, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada
Claire Lauzon, Department of Psychology, York University, Toronto, Canada
Peter Giacobbe, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada
Sean Nestor, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada
Stefan Köhler, Department of Psychology, University of Western Ontario, London, Canada
R. Rosenbaum, Department of Psychology, Centre for Vision Research, York University, Toronto, Canada
Sandra Black, Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and Sunnybrook Research Institute, University of Toronto, Toronto, Canada
Maged Goubran, LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada
Nir Lipsman, Division of Neurosurgery, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
Jennifer Rabin, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada

Category: Psychiatric Disorders

Keyword 1: depression
Keyword 2: neuromodulation
Keyword 3: memory complaints

Objective:

Electroconvulsive therapy (ECT) is widely recognized as an effective treatment for major depressive disorder (MDD). However, there are concerns regarding its effect on memory. Recent research suggests that ECT may disproportionally affect memories formed in close temporal proximity to ECT, while older memories remain unaffected. In the present study, we developed a novel self-report scale of retrograde memory to test this hypothesis. We also contrasted performance on this scale with a validated self-report measure of anterograde memory.

Participants and Methods:

Individuals diagnosed with unipolar or bipolar depression were tested before and approximately 1 month (mean=28.6 days) after an acute course of ECT. Healthy control participants were tested at a single time point. To assess retrograde memory, participants completed a novel self-report scale known as the Subjective Appraisal of Retrospective Memory (SARM). The SARM uses a visual analogue scale to assess the extent to which participants can vividly and confidently recall detailed events across 5 distinct life periods: the past month, 1 to 6 months, 6 to 12 months, 1 to 5 years, and 5 to 10 years. Participants also completed a published self-report measure of anterograde memory (Multifactorial Memory Questionnaire (MMQ): Memory Mistakes scale). This scale assesses self-perceived everyday memory abilities by asking participants to rate how frequently they experience each of 20 common memory mistakes over the previous 2 weeks. Memory abilities were compared between patients and controls at baseline using ANCOVA, adjusting for age and sex. ECT-related memory changes were assessed using paired t-tests.

Results:

The study included 17 individuals with treatment-refractory MDD (mean age: 42.3 [SD:12.5] years; 10 [58.9%] female) and 5 control participants (mean age: 44.6 [SD:20.5], 1 [20.0%] female). Compared to controls, individuals with MDD reported greater difficulty remembering past events across all time periods on the SARM (p-value range: 0.005-0.1) and endorsed more pronounced memory difficulties on the MMQ Memory Mistakes scale (F(1,16) = 6.14, p = 0.025). Regarding changes in retrograde memory due to ECT, individuals with MDD reported significantly greater difficulty remembering events from the month immediately preceding ECT treatment (t(13) = 2.2, p=0.048). However, there were no significant changes in memory recall for the other time periods on the SARM, including 1 to 6 months (t(13) = -0.0089, p =0.99), 6 to 12 months (t(13) = -0.77, p=0.46), 1 to 5 years (t(13) = -1.69, p=0.11), and 5 to 10 years ago (t(13) = -1.06, p=0.31). In terms of anterograde memory, there were no significant changes following ECT on the MMQ Memory Mistakes scale (t(13) = 1.67, p =0.12).

Conclusions:

Using a novel self-report scale, our findings suggest that ECT may negatively impact the recall of episodic memories formed within the month prior to treatment, while more remote memories are unchanged. In addition, self-perceived anterograde memory does not seem to be affected by ECT. Future work will examine the relationships between hippocampal morphometry and retrograde/anterograde subjective memory performance following ECT.