INS NYC 2024 Program

Poster	Poster Session 05 Program Schedule 02/15/2024 02:30 pm - 03:45 pm Room: Shubert Complex (Posters 1-60) Poster Session 05: Neuropsychiatry \| Addiction/Dependence \| Stress/Coping \| Emotional/Social Processes Final Abstract #55 Semantic Fluency Across Biotypes and Diagnoses Elmma Khalid, Rosalind Franklin University of Medicine and Science, North Chicago, United States Madison Dykins, Rosalind Franklin University of Medicine and Science, North Chicago, United States Sophia Parmacek, Rosalind Franklin University of Medicine and Science, North Chicago, United States Mira Leese, Rosalind Franklin University of Medicine and Science, North Chicago, United States Izhani Rosa, Rosalind Franklin University of Medicine and Science, North Chicago, United States Nancy Lundin, Ohio State University Wexner Medical Center, Columbus, United States Scot Hill, Rosalind Franklin University of Medicine and Science, North Chicago, United States Category: Schizophrenia/Psychosis Keyword 1: fluency Keyword 2: semantic processing Keyword 3: schizophrenia Objective: Cognitive dysfunction associated with psychosis spectrum disorders includes impaired verbal fluency characterized by deficits in semantic strategies such as increased switching and decreased clustering. Previous research has focused on semantic fluency deficits in traditional DSM diagnoses. However, recently the Bipolar Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium has developed biologically relevant classifications for psychotic disorders called “biotypes” based on neurophysiological and neuropsychological measures. The present study compared semantic fluency performance across DSM psychosis spectrum diagnoses and the B-SNIP “biotypes” to assess the sensitivity of both classification systems to verbal fluency deficits. Participants and Methods: Participants were 250 outpatients diagnosed with schizophrenia, bipolar disorder with psychosis, or schizoaffective disorder and categorized into one of three biotypes as well as 150 demographically similar healthy controls. The present sample consisted of males and females (50.4% male, 49.6% female) who were middle-aged on average (M_age=39.29, SD=11.54) and racially diverse (40.0% Caucasian/White, 41.4% African American/Black, 18.7% Other race or ethnicity). All participants were administered a semantic fluency test (i.e., animal names) as part of a larger cognitive battery. A series of one-way analysis of variance were conducted to examine potential group differences. Results: All three biotypes produced significantly fewer correct responses compared to healthy controls. Biotypes 1 and 2 generated significantly less switches compared to healthy controls. However, only Biotype 1 differed significantly from controls in terms of the proportion of correct responses that were switches. The DSM groups did not differ significantly from controls or each other in terms of switches, mean cluster size, and proportion of correct responses that were switches. Conclusions: Findings indicated that Biotype 1 generated fewer correct responses and clusters, yet had a greater proportion of switches. This pattern suggests a more disorganized, inefficient approach to semantic fluency tasks in Biotype 1 compared to healthy controls. The lack of DSM group differentiation also suggests that the biotype approach may be more sensitive to semantic fluency dysfunction and the organizational clustering and switching inherent in the task. Traditional scoring of semantic fluency (i.e., total correct responses) may not be sensitive to the unique organizational dysfunction displayed by Biotype 1 patients.

Poster

02/15/2024
02:30 pm - 03:45 pm
Room: Shubert Complex (Posters 1-60)

Poster Session 05: Neuropsychiatry | Addiction/Dependence | Stress/Coping | Emotional/Social Processes

Final Abstract #55

Semantic Fluency Across Biotypes and Diagnoses

Elmma Khalid, Rosalind Franklin University of Medicine and Science, North Chicago, United States
Madison Dykins, Rosalind Franklin University of Medicine and Science, North Chicago, United States
Sophia Parmacek, Rosalind Franklin University of Medicine and Science, North Chicago, United States
Mira Leese, Rosalind Franklin University of Medicine and Science, North Chicago, United States
Izhani Rosa, Rosalind Franklin University of Medicine and Science, North Chicago, United States
Nancy Lundin, Ohio State University Wexner Medical Center, Columbus, United States
Scot Hill, Rosalind Franklin University of Medicine and Science, North Chicago, United States

Category: Schizophrenia/Psychosis

Keyword 1: fluency
Keyword 2: semantic processing
Keyword 3: schizophrenia

Objective:

Cognitive dysfunction associated with psychosis spectrum disorders includes impaired verbal fluency characterized by deficits in semantic strategies such as increased switching and decreased clustering. Previous research has focused on semantic fluency deficits in traditional DSM diagnoses. However, recently the Bipolar Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium has developed biologically relevant classifications for psychotic disorders called “biotypes” based on neurophysiological and neuropsychological measures. The present study compared semantic fluency performance across DSM psychosis spectrum diagnoses and the B-SNIP “biotypes” to assess the sensitivity of both classification systems to verbal fluency deficits.

Participants and Methods:

Participants were 250 outpatients diagnosed with schizophrenia, bipolar disorder with psychosis, or schizoaffective disorder and categorized into one of three biotypes as well as 150 demographically similar healthy controls. The present sample consisted of males and females (50.4% male, 49.6% female) who were middle-aged on average (M_age=39.29, SD=11.54) and racially diverse (40.0% Caucasian/White, 41.4% African American/Black, 18.7% Other race or ethnicity). All participants were administered a semantic fluency test (i.e., animal names) as part of a larger cognitive battery. A series of one-way analysis of variance were conducted to examine potential group differences.

Results:

All three biotypes produced significantly fewer correct responses compared to healthy controls. Biotypes 1 and 2 generated significantly less switches compared to healthy controls. However, only Biotype 1 differed significantly from controls in terms of the proportion of correct responses that were switches. The DSM groups did not differ significantly from controls or each other in terms of switches, mean cluster size, and proportion of correct responses that were switches.

Conclusions:

Findings indicated that Biotype 1 generated fewer correct responses and clusters, yet had a greater proportion of switches. This pattern suggests a more disorganized, inefficient approach to semantic fluency tasks in Biotype 1 compared to healthy controls. The lack of DSM group differentiation also suggests that the biotype approach may be more sensitive to semantic fluency dysfunction and the organizational clustering and switching inherent in the task. Traditional scoring of semantic fluency (i.e., total correct responses) may not be sensitive to the unique organizational dysfunction displayed by Biotype 1 patients.