INS NYC 2024 Program

Poster	Poster Session 05 Program Schedule 02/15/2024 02:30 pm - 03:45 pm Room: Shubert Complex (Posters 1-60) Poster Session 05: Neuropsychiatry \| Addiction/Dependence \| Stress/Coping \| Emotional/Social Processes Final Abstract #20 Event-related potentials during Go/NoGo tasks predict neuropsychological functioning in veterans with chronic symptoms from traumatic brain injury Hsueh-sheng Chiang, University of Texas Southwestern Medical Center, Dallas, United States Michael Kraut, The Johns Hopkins University School of Medicine, Baltimore, United States Michael Motes, The University of Texas at Dallas, Richardson, United States Christian LoBue, University of Texas Southwestern Medical Center, Dallas, United States C Cullum, University of Texas Southwestern Medical Center, Dallas, United States John Hart Jr, The University of Texas at Dallas, Richardson, United States Category: Acquired Brain Injury (TBI/Cerebrovascular Injury and Disease - Adult) Keyword 1: traumatic brain injury Keyword 2: cognitive functioning Keyword 3: neurophysiology Objective: Long-term cognitive effects of traumatic brain injury (TBI) in military personnel have been reported but their underlying biological mechanisms remain complex and unclear. We assessed how event-related potentials (ERPs) during two Go/NoGo tasks, indicative of cognitive control and response monitoring, predicted cognitive performance and how TBI history with and without loss of consciousness (LOC) affected this relationship. Participants and Methods: Veterans (N = 55, age = 41.6 ± 10.5, 4 women) with a self-reported history of TBI (at least one year since the last injury) and chronic cognitive symptoms underwent a cognitive battery and two Go/NoGo tasks with concurrent EEG recording. During these Go/NoGo tasks, subjects were instructed to push a button for certain stimuli while withholding responses for others. The Go and NoGo trials were pictures of cars and dogs in one task, and pictures of non-animal objects and animals in the other, respectively. Two classic ERP components, frontal N2 (150-300 msec post stimulus onset) and fronto-central P3 (250-600 msec post stimulus onset), were analyzed. Peak latency and mean amplitude of the N2 and P3 components were used as variables in generalized linear models to predict composite scores from tests of executive function (Trail-Making Test B, Stroop Color and Word Interference), word retrieval (Boston Naming Test, Letter and Category Fluency), processing speed (Trail Making Test A, Stroop Color and Word Naming/Reading), and episodic memory (Rey-Auditory Verbal Learning Test-total learning and delayed recall), while controlling for age, sex, years of education, Becker Depression Inventory-II score, and behavioral measures (reaction time and accuracy) from the Go/NoGo tasks. This analysis was performed for the entire group and separately for 3 subgroups who had TBIs with or without LOC (N=12 with 0, N = 21 with 1-2, N = 22 with >2 of TBIs with LOC). Results: P3 amplitude for both Go and NoGo trials predicted neuropsychological composite measures in word retrieval, executive function, and processing speed (all ps < 0.05), but not episodic memory (p > 0.1). Smaller P3 amplitude correlated with lower cognitive performance (R²of 0.1 to 0.21). In contrast, N2 latency/amplitude and P3 latency did not consistently predict performance for any measures. In subgroup analyses, prediction using P3 amplitude was only significant for those reporting TBIs resulting in LOC. Conclusions: Our findings suggest that persistent cognitive symptoms due to TBI, especially in those with LOC, may be selectively mediated by neural processes associated with P3. This fronto-central P3 ERP component is thought to indicate response monitoring (for both response selection and inhibition) and summation of coordinated activity from a wide network of cortical regions, which could be impacted by TBI. This may serve as a potentially sensitive brain marker to detect cognitive sequelae in non-recovered TBI and to monitor effects in those who undergo intervention for cognitive deficits.

Poster

02/15/2024
02:30 pm - 03:45 pm
Room: Shubert Complex (Posters 1-60)

Poster Session 05: Neuropsychiatry | Addiction/Dependence | Stress/Coping | Emotional/Social Processes

Final Abstract #20

Event-related potentials during Go/NoGo tasks predict neuropsychological functioning in veterans with chronic symptoms from traumatic brain injury

Hsueh-sheng Chiang, University of Texas Southwestern Medical Center, Dallas, United States
Michael Kraut, The Johns Hopkins University School of Medicine, Baltimore, United States
Michael Motes, The University of Texas at Dallas, Richardson, United States
Christian LoBue, University of Texas Southwestern Medical Center, Dallas, United States
C Cullum, University of Texas Southwestern Medical Center, Dallas, United States
John Hart Jr, The University of Texas at Dallas, Richardson, United States

Category: Acquired Brain Injury (TBI/Cerebrovascular Injury and Disease - Adult)

Keyword 1: traumatic brain injury
Keyword 2: cognitive functioning
Keyword 3: neurophysiology

Objective:

Long-term cognitive effects of traumatic brain injury (TBI) in military personnel have been reported but their underlying biological mechanisms remain complex and unclear. We assessed how event-related potentials (ERPs) during two Go/NoGo tasks, indicative of cognitive control and response monitoring, predicted cognitive performance and how TBI history with and without loss of consciousness (LOC) affected this relationship.

Participants and Methods:

Veterans (N = 55, age = 41.6 ± 10.5, 4 women) with a self-reported history of TBI (at least one year since the last injury) and chronic cognitive symptoms underwent a cognitive battery and two Go/NoGo tasks with concurrent EEG recording. During these Go/NoGo tasks, subjects were instructed to push a button for certain stimuli while withholding responses for others. The Go and NoGo trials were pictures of cars and dogs in one task, and pictures of non-animal objects and animals in the other, respectively. Two classic ERP components, frontal N2 (150-300 msec post stimulus onset) and fronto-central P3 (250-600 msec post stimulus onset), were analyzed. Peak latency and mean amplitude of the N2 and P3 components were used as variables in generalized linear models to predict composite scores from tests of executive function (Trail-Making Test B, Stroop Color and Word Interference), word retrieval (Boston Naming Test, Letter and Category Fluency), processing speed (Trail Making Test A, Stroop Color and Word Naming/Reading), and episodic memory (Rey-Auditory Verbal Learning Test-total learning and delayed recall), while controlling for age, sex, years of education, Becker Depression Inventory-II score, and behavioral measures (reaction time and accuracy) from the Go/NoGo tasks. This analysis was performed for the entire group and separately for 3 subgroups who had TBIs with or without LOC (N=12 with 0, N = 21 with 1-2, N = 22 with >2 of TBIs with LOC).

Results:

P3 amplitude for both Go and NoGo trials predicted neuropsychological composite measures in word retrieval, executive function, and processing speed (all ps < 0.05), but not episodic memory (p > 0.1). Smaller P3 amplitude correlated with lower cognitive performance (R²of 0.1 to 0.21). In contrast, N2 latency/amplitude and P3 latency did not consistently predict performance for any measures. In subgroup analyses, prediction using P3 amplitude was only significant for those reporting TBIs resulting in LOC.

Conclusions:

Our findings suggest that persistent cognitive symptoms due to TBI, especially in those with LOC, may be selectively mediated by neural processes associated with P3. This fronto-central P3 ERP component is thought to indicate response monitoring (for both response selection and inhibition) and summation of coordinated activity from a wide network of cortical regions, which could be impacted by TBI. This may serve as a potentially sensitive brain marker to detect cognitive sequelae in non-recovered TBI and to monitor effects in those who undergo intervention for cognitive deficits.