Poster Session 04 Program Schedule
02/15/2024
12:00 pm - 01:15 pm
Room: Majestic Complex (Posters 61-120)
Poster Session 04: Neuroimaging | Neurostimulation/Neuromodulation | Teleneuropsychology/Technology
Final Abstract #65
A Systematic Review of Inflammatory Markers Structural Neuroimaging and Cognition in Older Adults without Cognitive Impairment
Kailey Langer, University of Florida, Gainesville, United States
Ronald Cohen, University of Florida, Gainesville, United States
Adam Woods, University of Florida, Gainesville, United States
Category: Aging
Keyword 1: aging (normal)
Keyword 2: cognitive functioning
Keyword 3: brain structure
Objective:
Objectives include assessing research support for relationships between various peripheral markers of inflammation and cognitive as well as structural brain health outcomes in healthy older adults.
Participants and Methods:
Systematic review was conducted by searching terms related to inflammatory markers, cognitive performance, and structural neuroimaging in older adults without cognitive impairment. The following databases were searched 8/25/2022: PubMed, PsycInfo (EBSCO), Web of Science, and Psychological and Behavioral Sciences Collection. Exclusion criteria included age < 55, cognitive impairment, animal research, publication not in English, and collection of cerebrospinal fluid to assess inflammatory markers. Cochrane risk of bias tool version 2 was used.
Results:
27 studies were included with most studies focusing on cognitive outcomes. Overall evidence was characterized by low certainty and small effects. CRP was the most reliably associated with outcomes, consistently providing larger effect sizes compared with other markers. IL-6 and CRP were the mostly frequently analyzed. The most consistent evidence with the highest overall magnitude of effect was observed for grey matter though memory was most investigated as an outcome. Missing data was the most prominent cause of reduced certainty.
Conclusions:
Evidence was severely limited by poor certainty and inconsistent methodology. Recommendations include avoiding inflammatory composite score, quantify inflammatory markers categorically rather than continuously, and improve consistency in the cognitive battery. One possible solution is incorporating validated, fixed research batteries to assess cognitive functioning.
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