| Poster | Poster Session 04 Program Schedule
02/15/2024
12:00 pm - 01:15 pm
Room: Majestic Complex (Posters 61-120)
Poster Session 04: Neuroimaging | Neurostimulation/Neuromodulation | Teleneuropsychology/Technology
Final Abstract #63
Purpose in Life Moderates the Association between Age-Related Left Hippocampal Volume and Memory Function in Older Adults
Hyunjeong Kwak, Department of Psychology, Seoul National University, Seoul, Korea, Republic of
Hyeyoung Park, Department of Psychology, Seoul National University, Seoul, Korea, Republic of
Jinkook Lee, Center for Economic and Social Research, University of Southern California, Los Angeles, United States
Jeanyung Chey, Department of Psychology, Seoul National University, Seoul, Korea, Republic of
Category: Aging
Keyword 1: cognitive reserve
Keyword 2: aging (normal)
Keyword 3: hippocampus
Objective:
Purpose in life(PIL), which is a central component of the eudemonic paradigm of well-being, has been associated with cognitive function as well as physical function in late life. However, it is unclear how PIL affects cognitive function with age. Therefore, we examined how the effects of age on memory function through hippocampal volume are modified by purpose in life in healthy older adults.
Participants and Methods:
Ninety-six healthy adults aged 60 years or older (mean age=69.8, SD=5.46) underwent an assessment of Purpose in life(Ryff, 1989) and a memory function test. Participants completed T1-structural scans, which were used to estimate the left hippocampal volume with CAT12 toolbox, and were divided into two groups based on the average PIL score, such as high PIL and low PIL. Gender, education level, and depressive symptoms were included as covariates in all analyses. This study conducted the moderated-mediation analysis using SPSS and Process macro 4.2.
Results:
In the mediation analysis, gray matter volume in the left hippocampus fully mediated the association between age and memory performance(B=.014, 95% CI= -.031, -.002), and also this indirect effect was moderated by PIL controlling for covariates(B=.018, 95% CI= .001, .047). In other words, age negatively affected memory performance through reduced hippocampal volume, and age-related memory function through left hippocampal volume was significant in older adults who had lower PIL, but not in those who had higher PIL.
Conclusions:
The results show that higher purpose in life may protect the late-life memory function against age-related reductions of left hippocampal volume. These findings suggest that interventions aimed at promoting an individual’s purpose in life may mitigate age-induced memory impairment in older adults.
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