INS NYC 2024 Program

Poster	Poster Session 04 Program Schedule 02/15/2024 12:00 pm - 01:15 pm Room: Shubert Complex (Posters 1-60) Poster Session 04: Neuroimaging \| Neurostimulation/Neuromodulation \| Teleneuropsychology/Technology Final Abstract #43 Subcortical Shape Changes at Age 10 Predictive of Non-Suicidal Self-Injury in Adolescents 2 Years Later: Findings from the ABCD Study Sonya Gupta, Northwestern University Feinberg School of Medicine, Chicago, United States Tiffanie Che, Northwestern University Feinberg School of Medicine, Chicago, United States Ashley Heywood, Northwestern University Feinberg School of Medicine, Chicago, United States Maryam Kouchakidivkolaei, Simon Fraser University, Burnaby, Canada Melinda Schreiner, University of Utah, Salt Lake City, United States Kwang-Youn Kim, Northwestern University Feinberg School of Medicine, Chicago, United States Jason Washburn, Northwestern University Feinberg School of Medicine, Chicago, United States Stew Shankman, Northwestern University Feinberg School of Medicine, Chicago, United States Lei Wang, Ohio State University College of Medicine, Columbus, United States Lisanne Jenkins, Northwestern University Feinberg School of Medicine, Chicago, United States Category: Neuroimaging Keyword 1: adolescence Keyword 2: brain structure Keyword 3: emotional processes Objective: Non-suicidal self-injury (NSSI) is the deliberate destruction of one’s body tissue without suicidal intent. Typical age of onset of NSSI is around 13-14, and the lifetime prevalence is 17-18%. NSSI in adolescents is associated with emergency department visits, hospitalizations, and suicide; however, few neuroimaging studies examining NSSI in adolescents exist, particularly in males, and most are cross-sectional. Evidence suggests that NSSI is associated with emotional regulation deficits and increased activity in the salience and cognitive control networks. However, the subcortical structural underpinnings are poorly understood. Using longitudinal data from the Adolescent Brain Cognitive Development (ABCD) study, the current study aimed to identify subcortical structural MRI abnormalities at baseline that predicted onset of NSSI by Year 2 (Y2). Participants and Methods: NSSI at Y2 was defined from the suicidal module of the self-report Kiddie Schedule for Affective Disorders and Schizophrenia from ABCD 5.0 release. 141 individuals (ages 9-10 at baseline, 71=female) with NSSI were matched to 141 controls without NSSI at Y2 on sex, race, ethnicity, pubertal stage, parental marital status, family income, and mood/anxiety diagnoses. Exclusion criteria for both groups were baseline NSSI and suicidal ideation or attempt at baseline or Y2. Due to incomplete data and quality assessments, 133 NSSI participants and 133 matched controls were included. Regions of interest (ROIs) were the amygdala, caudate, hippocampus, nucleus accumbens, pallidum, putamen, and thalamus. Covariates were pubertal stage, race, intracranial volume, and age. Surface analysis compared groups on baseline T1-weighted MRIs using FreeSurfer-initiated Large-Deformation Diffeomorphic Metric Mapping, applying a random field theory of p<0.01 and FWER at p<0.007 to correct for seven ROIs. Females and males were analyzed separately due to sex differences in brain development. Results: Relative to controls, females with NSSI had positive associations (indicative of outward deformations) on the right posterior subiculum of the hippocampus and inferior putamen. Females also showed negative associations (indicative of inward deformations) on the right superior putamen and inferior thalamus, left anterior pallidum, and bilateral caudate head and superior body. Males with NSSI showed negative associations on the posterior hippocampal tail in the CA1 region, and posterior subiculum, relative to matched controls. Exploratory correlation analyses revealed that inward hippocampal deformation in males was associated with higher sensation-seeking and lower parental acceptance at baseline. In females, inward deformation of the bilateral caudate head was associated with higher parental acceptance and more favorable school environment. Inward putamen deformation was also associated with higher parental acceptance and higher sensation-seeking. Conclusions: This is the first study to identify subcortical morphology associated with subsequent development of NSSI. Our results show consistency with previous cross-sectional subcortical volumetric studies of NSSI in adolescents. Further, our finding of opposing relationships by sex between subcortical deformations and behavioral variables is consistent with our previous work, emphasizing the importance of considering sex differences and environmental risk factors for NSSI. A major strength of this study is the large, longitudinal sample and considerable proportion of males. Our findings offer significant insights into the biology of NSSI in adolescents, reflecting potential deficits in regions associated with cognitive control of emotion.

Poster

02/15/2024
12:00 pm - 01:15 pm
Room: Shubert Complex (Posters 1-60)

Poster Session 04: Neuroimaging | Neurostimulation/Neuromodulation | Teleneuropsychology/Technology

Final Abstract #43

Subcortical Shape Changes at Age 10 Predictive of Non-Suicidal Self-Injury in Adolescents 2 Years Later: Findings from the ABCD Study

Sonya Gupta, Northwestern University Feinberg School of Medicine, Chicago, United States
Tiffanie Che, Northwestern University Feinberg School of Medicine, Chicago, United States
Ashley Heywood, Northwestern University Feinberg School of Medicine, Chicago, United States
Maryam Kouchakidivkolaei, Simon Fraser University, Burnaby, Canada
Melinda Schreiner, University of Utah, Salt Lake City, United States
Kwang-Youn Kim, Northwestern University Feinberg School of Medicine, Chicago, United States
Jason Washburn, Northwestern University Feinberg School of Medicine, Chicago, United States
Stew Shankman, Northwestern University Feinberg School of Medicine, Chicago, United States
Lei Wang, Ohio State University College of Medicine, Columbus, United States
Lisanne Jenkins, Northwestern University Feinberg School of Medicine, Chicago, United States

Category: Neuroimaging

Keyword 1: adolescence
Keyword 2: brain structure
Keyword 3: emotional processes

Objective:

Non-suicidal self-injury (NSSI) is the deliberate destruction of one’s body tissue without suicidal intent. Typical age of onset of NSSI is around 13-14, and the lifetime prevalence is 17-18%. NSSI in adolescents is associated with emergency department visits, hospitalizations, and suicide; however, few neuroimaging studies examining NSSI in adolescents exist, particularly in males, and most are cross-sectional. Evidence suggests that NSSI is associated with emotional regulation deficits and increased activity in the salience and cognitive control networks. However, the subcortical structural underpinnings are poorly understood. Using longitudinal data from the Adolescent Brain Cognitive Development (ABCD) study, the current study aimed to identify subcortical structural MRI abnormalities at baseline that predicted onset of NSSI by Year 2 (Y2).

Participants and Methods:

NSSI at Y2 was defined from the suicidal module of the self-report Kiddie Schedule for Affective Disorders and Schizophrenia from ABCD 5.0 release. 141 individuals (ages 9-10 at baseline, 71=female) with NSSI were matched to 141 controls without NSSI at Y2 on sex, race, ethnicity, pubertal stage, parental marital status, family income, and mood/anxiety diagnoses. Exclusion criteria for both groups were baseline NSSI and suicidal ideation or attempt at baseline or Y2. Due to incomplete data and quality assessments, 133 NSSI participants and 133 matched controls were included. Regions of interest (ROIs) were the amygdala, caudate, hippocampus, nucleus accumbens, pallidum, putamen, and thalamus. Covariates were pubertal stage, race, intracranial volume, and age. Surface analysis compared groups on baseline T1-weighted MRIs using FreeSurfer-initiated Large-Deformation Diffeomorphic Metric Mapping, applying a random field theory of p<0.01 and FWER at p<0.007 to correct for seven ROIs. Females and males were analyzed separately due to sex differences in brain development.

Results:

Relative to controls, females with NSSI had positive associations (indicative of outward deformations) on the right posterior subiculum of the hippocampus and inferior putamen. Females also showed negative associations (indicative of inward deformations) on the right superior putamen and inferior thalamus, left anterior pallidum, and bilateral caudate head and superior body. Males with NSSI showed negative associations on the posterior hippocampal tail in the CA1 region, and posterior subiculum, relative to matched controls. Exploratory correlation analyses revealed that inward hippocampal deformation in males was associated with higher sensation-seeking and lower parental acceptance at baseline. In females, inward deformation of the bilateral caudate head was associated with higher parental acceptance and more favorable school environment. Inward putamen deformation was also associated with higher parental acceptance and higher sensation-seeking.

Conclusions:

This is the first study to identify subcortical morphology associated with subsequent development of NSSI. Our results show consistency with previous cross-sectional subcortical volumetric studies of NSSI in adolescents. Further, our finding of opposing relationships by sex between subcortical deformations and behavioral variables is consistent with our previous work, emphasizing the importance of considering sex differences and environmental risk factors for NSSI. A major strength of this study is the large, longitudinal sample and considerable proportion of males. Our findings offer significant insights into the biology of NSSI in adolescents, reflecting potential deficits in regions associated with cognitive control of emotion.