INS NYC 2024 Program

Poster	Poster Session 03 Program Schedule 02/15/2024 09:30 am - 10:40 am Room: Majestic Complex (Posters 61-120) Poster Session 03: Neurotrauma \| Neurovascular Final Abstract #87 Understanding the Relationship Between Post-Concussion Symptoms and Physiological Depression in Traumatic Brain Injury: Implications for Rehabilitation. Nekabari Yakpogoro, The University Of Arizona, Tucson, United States Palmer Grabner, The University Of Arizona, Tucson, United States Shivani Desai, The University Of Arizona, Tucson, United States Lindsey Hildebrand, The University Of Arizona, Tucson, United States Alisa Huskey, The University Of Arizona, Tucson, United States William Killgore, The University Of Arizona, Tucson, United States Category: Acquired Brain Injury (TBI/Cerebrovascular Injury and Disease - Adult) Keyword 1: depression Keyword 2: brain injury Objective: Prior research studies have indicated increased prevalence of depression after a concussion (Vargas et al., 2015).However, research has not explored the relationship between physiological depression and its effects on both early post-concussive symptoms that emerge shortly after the injury, and later post-concussive symptoms, which manifest in the days, weeks, or months following the injury. Prevalent post-concussive symptoms include headaches, irritability, anxiety, dizziness, fatigue, and impaired concentration (Herrmann M.D. et al., 2009). We aim to contribute to a deeper understanding of the role of physiological depression in shaping the course of post-concussive recovery. We hypothesize that physiological depression is a predictive factor for both early and later post-concussive symptom severity, with potentially distinct effects on each stage. Participants and Methods: There were a total of one-hundred and fifty adults with mTBI(M_age= 24.48, SD= 6.80). Thirty of these adults were in the healthy control group. The measures were collected at two weeks (N=12), one month (N= 30), three months (N= 34), six months (N= 33) or one year post TBI (N= 42). For this analysis, we excluded the healthy control group and analyzed one-hundred and thirteen adults from this data. The Rivermead Post Concussion Symptoms Questionnaire (RPCSQ) was used to assess the severity of both early and late post-concussive symptoms. Higher RPCSQ scores correspond to heightened severity of post-concussive symptoms. The Personality Assessment Inventory was used to assess the physiological features of depression. Pearson correlations and a multiple regression were conducted to determine whether later post concussive symptoms or earlier post concussive symptoms significantly predicted physiological depression. Results: The regression analysis demonstrated that physiological depression accounted for approximately 9.7% of the variance in early post concussive symptoms (R² = 0.097, F(1,110)= 12.362). With an increase in physiological depression corresponding to an increase in the level of early post- concussive symptoms (=0.325, p<.001). A multiple regression analysis demonstrated that physiological depression predicts 24% of the variance in late post concussive symptoms (R²=0.240, F(2,110) =34.421) with an increase in physiological depression increasing the level of early post concussive symptoms (=0.497, p<0.001). Conclusions: The results suggest that physiological depression is predictive of both early and late post-concussive symptomatology, but further shows that physiological depression accounts for nearly 2.5 times more variance in late post-concussive symptomatology compared to early symptoms. This suggests the relevance of physiological depression as a factor to consider when evaluating and managing post-concussive symptoms in individuals recuperating from traumatic brain injury. Depression symptoms, such as fatigue and cognitive difficulties, can overlap with other TBI-related symptoms, making it challenging to distinguish between them. Given this challenge and the high prevalence of depression, prioritizing depression monitoring becomes a more feasible construct for screening in individuals with TBI. Early management of depression can aid in improvement in various TBI-related outcomes by boosting engagement in rehabilitation, stabilizing mood, and reducing emotional and cognitive barriers.

Poster

02/15/2024
09:30 am - 10:40 am
Room: Majestic Complex (Posters 61-120)

Poster Session 03: Neurotrauma | Neurovascular

Final Abstract #87

Understanding the Relationship Between Post-Concussion Symptoms and Physiological Depression in Traumatic Brain Injury: Implications for Rehabilitation.

Nekabari Yakpogoro, The University Of Arizona, Tucson, United States
Palmer Grabner, The University Of Arizona, Tucson, United States
Shivani Desai, The University Of Arizona, Tucson, United States
Lindsey Hildebrand, The University Of Arizona, Tucson, United States
Alisa Huskey, The University Of Arizona, Tucson, United States
William Killgore, The University Of Arizona, Tucson, United States

Category: Acquired Brain Injury (TBI/Cerebrovascular Injury and Disease - Adult)

Keyword 1: depression
Keyword 2: brain injury

Objective:

Prior research studies have indicated increased prevalence of depression after a concussion (Vargas et al., 2015).However, research has not explored the relationship between physiological depression and its effects on both early post-concussive symptoms that emerge shortly after the injury, and later post-concussive symptoms, which manifest in the days, weeks, or months following the injury. Prevalent post-concussive symptoms include headaches, irritability, anxiety, dizziness, fatigue, and impaired concentration (Herrmann M.D. et al., 2009). We aim to contribute to a deeper understanding of the role of physiological depression in shaping the course of post-concussive recovery. We hypothesize that physiological depression is a predictive factor for both early and later post-concussive symptom severity, with potentially distinct effects on each stage.

Participants and Methods:

There were a total of one-hundred and fifty adults with mTBI(M_age= 24.48, SD= 6.80). Thirty of these adults were in the healthy control group. The measures were collected at two weeks (N=12), one month (N= 30), three months (N= 34), six months (N= 33) or one year post TBI (N= 42). For this analysis, we excluded the healthy control group and analyzed one-hundred and thirteen adults from this data. The Rivermead Post Concussion Symptoms Questionnaire (RPCSQ) was used to assess the severity of both early and late post-concussive symptoms. Higher RPCSQ scores correspond to heightened severity of post-concussive symptoms. The Personality Assessment Inventory was used to assess the physiological features of depression. Pearson correlations and a multiple regression were conducted to determine whether later post concussive symptoms or earlier post concussive symptoms significantly predicted physiological depression.

Results:

The regression analysis demonstrated that physiological depression accounted for approximately 9.7% of the variance in early post concussive symptoms (R² = 0.097, F(1,110)= 12.362). With an increase in physiological depression corresponding to an increase in the level of early post- concussive symptoms (=0.325, p<.001). A multiple regression analysis demonstrated that physiological depression predicts 24% of the variance in late post concussive symptoms (R²=0.240, F(2,110) =34.421) with an increase in physiological depression increasing the level of early post concussive symptoms (=0.497, p<0.001).

Conclusions:

The results suggest that physiological depression is predictive of both early and late post-concussive symptomatology, but further shows that physiological depression accounts for nearly 2.5 times more variance in late post-concussive symptomatology compared to early symptoms. This suggests the relevance of physiological depression as a factor to consider when evaluating and managing post-concussive symptoms in individuals recuperating from traumatic brain injury. Depression symptoms, such as fatigue and cognitive difficulties, can overlap with other TBI-related symptoms, making it challenging to distinguish between them. Given this challenge and the high prevalence of depression, prioritizing depression monitoring becomes a more feasible construct for screening in individuals with TBI. Early management of depression can aid in improvement in various TBI-related outcomes by boosting engagement in rehabilitation, stabilizing mood, and reducing emotional and cognitive barriers.