| Poster | Poster Session 03 Program Schedule
02/15/2024
09:30 am - 10:40 am
Room: Majestic Complex (Posters 61-120)
Poster Session 03: Neurotrauma | Neurovascular
Final Abstract #66
Cognitive Functioning across Ictal and Interictal Migraine Phases: An Ecological Momentary Assessment Study
Laura Sebrow, Department of Neurology, Northwell Health, Manhasset, United States
Alexandra Schwartz, Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, United States
Talia Korn, Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, United States
Megan Lacritz, Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, United States
Elizabeth Seng, Ferkauf Graduate School of Psychology, Yeshiva University; Department of Neurology, Albert Einstein College of Medicine, Bronx, United States
Category: Medical/Neurological Disorders/Other (Adult)
Keyword 1: chronic pain
Keyword 2: cognitive functioning
Keyword 3: anxiety
Objective:
Evaluate cognitive functioning during ictal and interictal migraine phases. Evaluate influence of psychological factors on cognitive performance during ictal and interictal phases.
Participants and Methods:
In this longitudinal study, 19 adults with migraine (Mdn age = 34.0, IQR = 27.0-39.0, 68.4% female, 84.2% white, M number of completed years of education = 16.5, SD = 2.48) completed baseline demographic and psychological questionnaires (PROMIS Anxiety and Cogniphobia Scale [CS-HD]), and an EMA (Ecological Momentary Assessment) protocol (five times per day for two to four weeks), which included a cognitive battery (i.e., Trail Making Test [TMT], Stroop Test, Spatial Memory Test), and headache questions. Separate mixed effects models were run for each cognitive outcome (each cognitive task) and each psychological factor (PROMIS Anxiety and CS-HD).
Results:
During ictal phases, there were fewer Spatial Memory successes (Estimate = -.20, CI = -.38, -.01, p = .038), Spatial Memory largest game successes (Estimate = -.22, CI = -.43, -.01, p = .038), and Stroop non-congruent items correct (Estimate = -.37, CI = -.70, -.03, p = .006; OR=3.03, CI=1.26-7.26, p = .013), and a greater number of Stroop non-congruent item errors (Estimate = .23, CI = .02, .44, p = .031). TMT parts A and B did not significantly differ based on migraine phase. Results also revealed that higher CS-HD scores were associated with a greater amount of Stroop non-congruent errors (Estimate = .13, CI = .02, .24, p = .029; OR=.90, CI=.83-.98, p = .010). No association was found between PROMIS Anxiety and any cognitive variables. Additionally, results revealed that migraine phase moderated relationships between PROMIS Anxiety scores and TMT B (Estimate = .12, CI = .04, .20, p = .003), PROMIS Anxiety scores and Stroop non-congruent items correct (Estimate = -.06, CI = -.10, -.02, p = .006), PROMIS Anxiety scores and Stroop non-congruent errors (Estimate = .04, CI = .02, .07, p = <.001; OR=.94, CI=.90, .98, p = .004), CS-HD Score and Stroop non-congruent items correct (Estimate = -.04, CI = -.07, -.01, p = .018), and CS-HD score and Stroop non-congruent errors (OR=.96, CI=.93, 1.00, p = .025).
Conclusions:
This was the first study to evaluate cognitive functioning across multiple migraine attacks via EMA. This study demonstrated that cognitive performance differed based on migraine phase, with weaker performance during ictal phases relative to the interictal phases. This study also showed that psychological factors (i.e., anxiety and Cogniphobia) impacted cognitive performance. Findings highlight cognition as a potential digital biomarker for identifying headache attacks; tracking real-time cognitive changes can provide valuable insight into timing and nature of cognitive difficulties related to migraine episodes.
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