INS NYC 2024 Program

Poster	Poster Session 03 Program Schedule 02/15/2024 09:30 am - 10:40 am Room: Shubert Complex (Posters 1-60) Poster Session 03: Neurotrauma \| Neurovascular Final Abstract #51 Neuroinflammatory Response Post Cardiac Event as Measured by Radioligand with Matched Affinity Binding and its Possible Role in Cognitive Performance Terina Myers, University of Alabama at Birmingham, Birmingham, United States Benjamin Jones, University of Alabama at Birmingham, Birmingham, United States Jonathan McConathy, University of Alabama at Birmingham, Birmingham, United States Yu-Hua Fang, University of Alabama at Birmingham, Birmingham, United States Adam Gerstenecker, University of Alabama at Birmingham, Birmingham, United States Christopher Collette, University of Alabama at Birmingham, Birmingham, United States David Standaert, University of Alabama at Birmingham, Birmingham, United States Talene Yacoubian, University of Alabama at Birmingham, Birmingham, United States Nita Limdi, University of Alabama at Birmingham, Birmingham, United States Anna Price, University of Alabama at Birmingham, Birmingham, United States Ronald Lazar, University of Alabama at Birmingham, Birmingham, United States Category: Other Keyword 1: cardiovascular disease Keyword 2: cognitive functioning Keyword 3: neuroimmunology Objective: To investigate the presence of neuroinflammation among individuals, post-cardiac event, along with its relationship with cognitive performance. Participants and Methods: We recruited 6 patients receiving either a percutaneous coronary intervention (PCI) following myocardial infarction (MI) or underwent an elective PCI as a preventative measure (2 MI and 4 elective PCI) who presented for treatment at the University of Alabama at Birmingham (UAB). Eligibility required individuals to undergo genotyping to determine whether they were a high, mixed, or low-affinity binder for the translocator protein (TSPO) DPA-714 to measure neuroinflammation by way of PET imaging. Only high and mixed binders were asked to participate in the study as they are the best determinants of microglial activation. Additionally, patients underwent a comprehensive neuropsychological battery, and serum blood samples were collected. Cognitive data was divided into an overall Cognitive Composite score and five cognitive domains (i.e., Verbal Memory, Working Memory, Executive Function, Language, and Attention) using z-score averages. Healthy control data was obtained for comparison from the Udall Center of Excellence in Parkinson’s Disease Research. Cognitive testing for the healthy controls (n=60) was compared to that of our study population to determine if the presence of cardiovascular disease, with or without cardiac event, affected cognitive performance. A subset of healthy controls (n=28) underwent genotyping and PET imaging procedures which were used to compare neuroinflammation to that of our study cohort. Results: Significant differences among high-affinity binders (n=3) emerged across multiple brain regions: thalamus (t(32)=3.554, p=.0001), hippocampus (t(32)=2.718, p=.011), frontal (t(32)=2.616, p=.013), temporal (t(32)=2.325, p=.027), occipital (t(32)=.942, p=.006), parietal (t(32)=2.980, p=.006), amygdala (t(32)=2.998, p=.005), striatum (t(32)=3.717, p=.0008), and cerebellum (t(32)=4.057, p=.0003). No significant differences were found among mixed-affinity binders (n=3). Cognitive data showed a significant difference in verbal memory delayed recall with our study population performing below that of healthy controls (F(1,64) = 14.722 p=<.001). Conclusions: Studies investigating associations between neuroinflammation and cognition following a cardiac event are lacking. Results from PET imaging data along with observed poorer performance in delayed verbal memory suggest a possible association between cardiovascular events and a neuroinflammatory response leading to changes in cognitive performance. These findings in a sample of patients with cardiovascular disease highlight the need for further research exploring the relationship between neuroinflammation and cognition in cardiovascular disease.

Poster

02/15/2024
09:30 am - 10:40 am
Room: Shubert Complex (Posters 1-60)

Poster Session 03: Neurotrauma | Neurovascular

Final Abstract #51

Neuroinflammatory Response Post Cardiac Event as Measured by Radioligand with Matched Affinity Binding and its Possible Role in Cognitive Performance

Terina Myers, University of Alabama at Birmingham, Birmingham, United States
Benjamin Jones, University of Alabama at Birmingham, Birmingham, United States
Jonathan McConathy, University of Alabama at Birmingham, Birmingham, United States
Yu-Hua Fang, University of Alabama at Birmingham, Birmingham, United States
Adam Gerstenecker, University of Alabama at Birmingham, Birmingham, United States
Christopher Collette, University of Alabama at Birmingham, Birmingham, United States
David Standaert, University of Alabama at Birmingham, Birmingham, United States
Talene Yacoubian, University of Alabama at Birmingham, Birmingham, United States
Nita Limdi, University of Alabama at Birmingham, Birmingham, United States
Anna Price, University of Alabama at Birmingham, Birmingham, United States
Ronald Lazar, University of Alabama at Birmingham, Birmingham, United States

Category: Other

Keyword 1: cardiovascular disease
Keyword 2: cognitive functioning
Keyword 3: neuroimmunology

Objective:

To investigate the presence of neuroinflammation among individuals, post-cardiac event, along with its relationship with cognitive performance.

Participants and Methods:

We recruited 6 patients receiving either a percutaneous coronary intervention (PCI) following myocardial infarction (MI) or underwent an elective PCI as a preventative measure (2 MI and 4 elective PCI) who presented for treatment at the University of Alabama at Birmingham (UAB). Eligibility required individuals to undergo genotyping to determine whether they were a high, mixed, or low-affinity binder for the translocator protein (TSPO) DPA-714 to measure neuroinflammation by way of PET imaging. Only high and mixed binders were asked to participate in the study as they are the best determinants of microglial activation. Additionally, patients underwent a comprehensive neuropsychological battery, and serum blood samples were collected. Cognitive data was divided into an overall Cognitive Composite score and five cognitive domains (i.e., Verbal Memory, Working Memory, Executive Function, Language, and Attention) using z-score averages. Healthy control data was obtained for comparison from the Udall Center of Excellence in Parkinson’s Disease Research. Cognitive testing for the healthy controls (n=60) was compared to that of our study population to determine if the presence of cardiovascular disease, with or without cardiac event, affected cognitive performance. A subset of healthy controls (n=28) underwent genotyping and PET imaging procedures which were used to compare neuroinflammation to that of our study cohort.

Results:

Significant differences among high-affinity binders (n=3) emerged across multiple brain regions: thalamus (t(32)=3.554, p=.0001), hippocampus (t(32)=2.718, p=.011), frontal (t(32)=2.616, p=.013), temporal (t(32)=2.325, p=.027), occipital (t(32)=.942, p=.006), parietal (t(32)=2.980, p=.006), amygdala (t(32)=2.998, p=.005), striatum (t(32)=3.717, p=.0008), and cerebellum (t(32)=4.057, p=.0003). No significant differences were found among mixed-affinity binders (n=3). Cognitive data showed a significant difference in verbal memory delayed recall with our study population performing below that of healthy controls (F(1,64) = 14.722 p=<.001).

Conclusions:

Studies investigating associations between neuroinflammation and cognition following a cardiac event are lacking. Results from PET imaging data along with observed poorer performance in delayed verbal memory suggest a possible association between cardiovascular events and a neuroinflammatory response leading to changes in cognitive performance. These findings in a sample of patients with cardiovascular disease highlight the need for further research exploring the relationship between neuroinflammation and cognition in cardiovascular disease.