Poster Session 03 Program Schedule
02/15/2024
09:30 am - 10:40 am
Room: Shubert Complex (Posters 1-60)
Poster Session 03: Neurotrauma | Neurovascular
Final Abstract #36
Executive Dysfunction Related to Binge Drinking in Ischemic Stroke - a 9-year follow-up
Siiri Laari, HUS Helsinki University Hospital, Helsinki, Finland
Tatu Kauranen, Lapland Hospital District, Rovaniemi, Finland
Katri Turunen, University of Helsinki, Helsinki, Finland
Satu Mustanoja, HUS Helsinki University Hospital, Helsinki, Finland
Turgut Tatlisumak, University of Helsinki, Helsinki, Finland
Erja Poutiainen, University of Helsinki, Helsinki, Finland
Category: Stroke/Cerebrovascular Injury and Disease (Adult)
Keyword 1: stroke
Keyword 2: substance abuse
Keyword 3: executive functions
Objective:
A recent study has shown that subdiagnostic binge drinking, which refers to social drinking that does not meet the criteria for Alcohol Use Disorder, could potentially worsen the negative impacts of ischemic stroke on executive cognitive function. However, it remains unclear whether prior binge drinking exerts a cumulative long-term impact on cognitive functioning of adults who have experienced a stroke.
We conducted a 9-year follow-up study to examine whether cognitive impairment following a stroke is related to a prior history of subdiagnostic binge drinking among patients who had experienced their first and only ischemic stroke.
Participants and Methods:
Participants were part of a prospective, two-center cohort study that initially recruited consecutive 18–65 year-old patients with acute stroke (206 stroke patients and 50 healthy, demographically comparable adults).
The participants in this long-term follow-up study consisted of 85 first-ever ischemic stroke patients (mean age 53 years at inclusion) and 31 healthy participants who participated in every visit including the final 9-year follow-up and fulfilled the criteria. Participants with alcohol use disorder, any additional brain etc. disease were excluded.
The non–binge-drinking group included 97 participants. The binge-drinking group included 19 participants. A multivariate analysis of covariance was used to compare nine cognitive functions between non-binge and binge-drinking groups, with age, education, and stroke severity used as covariates.
Results:
Binge drinking had a significant negative main effect on executive function (P = 0.032) 9 years after first-ever and only stroke. The binge-drinking group performed poorer than the non–binge-drinking group on the Stroop Test; Stroop difference time was significantly higher in the binge- drinking group than in the non–binge- drinking group (P = 0.013). Besides effect of binge drinking, there were main effects of both age, education and stroke severity for executive function, as expected.
Conclusions:
Subdiagnostic binge drinking may exacerbate the adverse effects of ischemic stroke on executive dysfunction 9-year post-stroke.
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