INS NYC 2024 Program

Poster	Poster Session 03 Program Schedule 02/15/2024 09:30 am - 10:40 am Room: Shubert Complex (Posters 1-60) Poster Session 03: Neurotrauma \| Neurovascular Final Abstract #33 Cognitive Implications of Microstructural White Matter Abnormalities in Aneurysmal and Angiographically Negative Subarachnoid Hemorrhage: a Diffusion Kurtosis Imaging Study Sara Khosdelazad, University Medical Centre Groningen, Groningen, Netherlands Harm-Jan Van der Horn, University Medical Centre Groningen, Groningen, Netherlands Lieke Jorna, University Medical Centre Groningen, Groningen, Netherlands Sandra Rakers, University Medical Centre Groningen, Groningen, Netherlands Anouk Van der Hoorn, University Medical Centre Groningen, Groningen, Netherlands Anne Buunk, University Medical Centre Groningen, Groningen, Netherlands Rob Groen, University Medical Centre Groningen, Groningen, Netherlands Jacoba Spikman, University Medical Centre Groningen, Groningen, Netherlands Category: Neuroimaging Keyword 1: neuroimaging: structural connectivity Keyword 2: subarachnoid hemorrhage Keyword 3: cognitive functioning Objective: Aneurysmal subarachnoid hemorrhage (aSAH) and angiographically negative subarachnoid hemorrhage (anSAH) can cause white matter injury from the abrupt rise in intracranial pressure, which directly damages the white matter tracts due to shearing forces. This study is the first to investigate whole-brain white matter abnormalities with diffusion kurtosis imaging (DKI) after both aSAH and anSAH and explored whether these abnormalities were associated with cognitive functioning Participants and Methods: We included 34 patients with aSAH, 24 patients with anSAH, and 17 healthy controls (HC). Five months post-ictus DKI MRI scanning and neuropsychological tests were conducted. We examined differences in DKI parameters (fractional anisotropy, mean diffusivity, axial diffusivity [AD], radial diffusivity [RD], and mean kurtosis) using tract-based spatial statistics. Significant voxel masks were then correlated with neuropsychological tests for the entire SAH group Results: Significant differences were found for all DKI parameters between patients with aSAH and HC, while differences between patients with anSAH and HC were only observed for RD. No significant differences were found between the two SAH groups on all DKI parameters. Slower psychomotor speed seems to be associated with higher AD and RD values, and poorer emotion recognition is linked to higher RD values Conclusions: Patients with aSAH have microstructural white matter abnormalities, and for the first time, these are also observed in the anSAH group, although less pronounced. Cognitive functioning seems to be associated with white matter injury after SAH, emphasizing the need for neuropsychological assessments in both SAH groups.

Poster

02/15/2024
09:30 am - 10:40 am
Room: Shubert Complex (Posters 1-60)

Poster Session 03: Neurotrauma | Neurovascular

Final Abstract #33

Cognitive Implications of Microstructural White Matter Abnormalities in Aneurysmal and Angiographically Negative Subarachnoid Hemorrhage: a Diffusion Kurtosis Imaging Study

Sara Khosdelazad, University Medical Centre Groningen, Groningen, Netherlands
Harm-Jan Van der Horn, University Medical Centre Groningen, Groningen, Netherlands
Lieke Jorna, University Medical Centre Groningen, Groningen, Netherlands
Sandra Rakers, University Medical Centre Groningen, Groningen, Netherlands
Anouk Van der Hoorn, University Medical Centre Groningen, Groningen, Netherlands
Anne Buunk, University Medical Centre Groningen, Groningen, Netherlands
Rob Groen, University Medical Centre Groningen, Groningen, Netherlands
Jacoba Spikman, University Medical Centre Groningen, Groningen, Netherlands

Category: Neuroimaging

Keyword 1: neuroimaging: structural connectivity
Keyword 2: subarachnoid hemorrhage
Keyword 3: cognitive functioning

Objective:

Aneurysmal subarachnoid hemorrhage (aSAH) and angiographically negative subarachnoid hemorrhage (anSAH) can cause white matter injury from the abrupt rise in intracranial pressure, which directly damages the white matter tracts due to shearing forces. This study is the first to investigate whole-brain white matter abnormalities with diffusion kurtosis imaging (DKI) after both aSAH and anSAH and explored whether these abnormalities were associated with cognitive functioning

Participants and Methods:

We included 34 patients with aSAH, 24 patients with anSAH, and 17 healthy controls (HC). Five months post-ictus DKI MRI scanning and neuropsychological tests were conducted. We examined differences in DKI parameters (fractional anisotropy, mean diffusivity, axial diffusivity [AD], radial diffusivity [RD], and mean kurtosis) using tract-based spatial statistics. Significant voxel masks were then correlated with neuropsychological tests for the entire SAH group

Results:

Significant differences were found for all DKI parameters between patients with aSAH and HC, while differences between patients with anSAH and HC were only observed for RD. No significant differences were found between the two SAH groups on all DKI parameters. Slower psychomotor speed seems to be associated with higher AD and RD values, and poorer emotion recognition is linked to higher RD values

Conclusions:

Patients with aSAH have microstructural white matter abnormalities, and for the first time, these are also observed in the anSAH group, although less pronounced. Cognitive functioning seems to be associated with white matter injury after SAH, emphasizing the need for neuropsychological assessments in both SAH groups.