INS NYC 2024 Program

Poster	Poster Session 03 Program Schedule 02/15/2024 09:30 am - 10:40 am Room: Shubert Complex (Posters 1-60) Poster Session 03: Neurotrauma \| Neurovascular Final Abstract #17 The Effects of Hazardous Alcohol Use on Emotional Regulation during TBI Recovery Shivani Desai, University of Arizona, Tucson, United States Melissa Reich-Fuehrer, University of Arizona, Tucson, United States Palmer Grabner, University of Arizona, Tucson, United States Lindsey Hildebrand, University of Arizona, Tucson, United States Alisa Huskey, University of Arizona, Tucson, United States William Killgore, University of Arizona, Tucson, United States Category: Concussion/Mild TBI (Adult) Keyword 1: alcohol Keyword 2: anxiety Keyword 3: depression Objective: Alcohol use has been documented to delay traumatic brain injury recovery by negatively affecting factors like concentration and memory; however, the effects of excess alcohol consumption on specific measures of emotional state after injury have not yet been examined. We hypothesized that individuals who engage in hazardous alcohol consumption will have higher levels of traumatic stress, anxiety, and depressive symptoms throughout their recovery period after a TBI compared to healthy individuals. Participants and Methods: Within a cross-sectional study design, we examined a total of 30 healthy participants and 106 participants with varying durations of time since injury (N_2weeks=10, N_1month=21, N_3months=23, N_6months=20, and N_12months=32). We further divided our participants based on their Alcohol Use Disorders Identification Test (AUDIT); scores below 8 were considered baseline and scores above 8 qualified as hazardous alcohol use according to official guidelines set by the World Health Organization (WHO). Measures of emotional state were collected using subscales of traumatic stress, anxiety, and depression on the Personality Assessment Inventories (PAI). We ran a MANOVA and applied False Discovery Rate (FDR) correction for multiple comparisons. Results: Overall, individuals who use hazardous amounts of alcohol had higher rates of traumatic stress, anxiety, and depression compared to non-hazardous alcohol users at 1-month post injury. Those 1-month post injury who reported higher alcohol consumption also reported higher levels of traumatic stress (M = 66.00, SD = 32.527) compared to the non-hazardous alcohol consumption group (M = 49.53, SD = 8.195) (p = 0.028). Those at 1 month that also consumed higher amounts of alcohol reported higher levels of depression (M = 65.00, SD = 21.213) compared to the non-hazardous alcohol consumption group (M = 49.79, SD = 7.330) (p = 0.031). Lastly, the high alcohol consumption group reported higher levels of generalized anxiety (M = 65.00, SD = 31.113) than the non-hazardous alcohol consumption group (M = 48.89, SD = 7.992) (p = 0.033) 1-month post-injury. To correct for multiple comparisons, we applied an FDR correction in which differences in depression (p = 0.033) and anxiety (p = 0.033) remained significant, but traumatic stress did not. Conclusions: We found that individuals who meet the criteria for hazardous alcohol use had significantly higher PAI scores for anxiety and depression at 1-month post-injury, while the group without hazardous alcohol use stayed relatively consistent with those PAI scores throughout their recovery period from 2 weeks post-injury to 1-year post-injury. This pattern indicates that during TBI recovery, individuals who have a history of engaging in excess consumption of alcohol may need additional psychiatric support or resources available for them to aid in their recovery. Future research can be done to examine underlying neurobiological mechanisms that result from high levels of alcohol use and impact TBI recovery.

Poster

02/15/2024
09:30 am - 10:40 am
Room: Shubert Complex (Posters 1-60)

Poster Session 03: Neurotrauma | Neurovascular

Final Abstract #17

The Effects of Hazardous Alcohol Use on Emotional Regulation during TBI Recovery

Shivani Desai, University of Arizona, Tucson, United States
Melissa Reich-Fuehrer, University of Arizona, Tucson, United States
Palmer Grabner, University of Arizona, Tucson, United States
Lindsey Hildebrand, University of Arizona, Tucson, United States
Alisa Huskey, University of Arizona, Tucson, United States
William Killgore, University of Arizona, Tucson, United States

Category: Concussion/Mild TBI (Adult)

Keyword 1: alcohol
Keyword 2: anxiety
Keyword 3: depression

Objective:

Alcohol use has been documented to delay traumatic brain injury recovery by negatively affecting factors like concentration and memory; however, the effects of excess alcohol consumption on specific measures of emotional state after injury have not yet been examined. We hypothesized that individuals who engage in hazardous alcohol consumption will have higher levels of traumatic stress, anxiety, and depressive symptoms throughout their recovery period after a TBI compared to healthy individuals.

Participants and Methods:

Within a cross-sectional study design, we examined a total of 30 healthy participants and 106 participants with varying durations of time since injury (N_2weeks=10, N_1month=21, N_3months=23, N_6months=20, and N_12months=32). We further divided our participants based on their Alcohol Use Disorders Identification Test (AUDIT); scores below 8 were considered baseline and scores above 8 qualified as hazardous alcohol use according to official guidelines set by the World Health Organization (WHO). Measures of emotional state were collected using subscales of traumatic stress, anxiety, and depression on the Personality Assessment Inventories (PAI). We ran a MANOVA and applied False Discovery Rate (FDR) correction for multiple comparisons.

Results:

Overall, individuals who use hazardous amounts of alcohol had higher rates of traumatic stress, anxiety, and depression compared to non-hazardous alcohol users at 1-month post injury. Those 1-month post injury who reported higher alcohol consumption also reported higher levels of traumatic stress (M = 66.00, SD = 32.527) compared to the non-hazardous alcohol consumption group (M = 49.53, SD = 8.195) (p = 0.028). Those at 1 month that also consumed higher amounts of alcohol reported higher levels of depression (M = 65.00, SD = 21.213) compared to the non-hazardous alcohol consumption group (M = 49.79, SD = 7.330) (p = 0.031). Lastly, the high alcohol consumption group reported higher levels of generalized anxiety (M = 65.00, SD = 31.113) than the non-hazardous alcohol consumption group (M = 48.89, SD = 7.992) (p = 0.033) 1-month post-injury. To correct for multiple comparisons, we applied an FDR correction in which differences in depression (p = 0.033) and anxiety (p = 0.033) remained significant, but traumatic stress did not.

Conclusions:

We found that individuals who meet the criteria for hazardous alcohol use had significantly higher PAI scores for anxiety and depression at 1-month post-injury, while the group without hazardous alcohol use stayed relatively consistent with those PAI scores throughout their recovery period from 2 weeks post-injury to 1-year post-injury. This pattern indicates that during TBI recovery, individuals who have a history of engaging in excess consumption of alcohol may need additional psychiatric support or resources available for them to aid in their recovery. Future research can be done to examine underlying neurobiological mechanisms that result from high levels of alcohol use and impact TBI recovery.