INS NYC 2024 Program

Poster	Poster Session 02 Program Schedule 02/15/2024 08:00 am - 09:15 am Room: Majestic Complex (Posters 61-120) Poster Session 02: Aging \| MCI \| Neurodegenerative Disease - PART 1 Final Abstract #102 Prospective Parental Diagnosis of Dementia is Associated White Matter Hyperintensities in Middle Age Rafael Lippert, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States Jeffrey Pyne, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States Indira Turney, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States Patrick Lao, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States A. Zarina Kraal, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States Natalie Edwards, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States Mohamad Alshikho, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States Joncarlos Berroa, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States Jose Gutierrez, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States Richard Mayeux, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States Jennifer Manly, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States Adam Brickman, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States Category: Dementia (Alzheimer's Disease) Keyword 1: dementia - Alzheimer's disease Keyword 2: vascular cognitive impairment Keyword 3: memory disorders Objective: Cerebrovascular disease is associated with risk for dementia and possibly Alzheimer’s disease (AD) pathogenesis. Parental history of dementia and white matter hyperintensities (WMH), a marker of small vessel cerebrovascular disease, are both risk factors for AD. In the current study, we examined whether parental history of dementia is associated with WMH and whether WMH mediate the association of parental dementia history with cognition in middle-aged adults. Participants and Methods: Six hundred thirty-eight middle-aged participants (mean+SD age=54.4+10.5, 65% women, 70% Latinx, 21% Black, 9% non-Latinx White) in the Offspring Study received MRI. Offspring Study participants are the adult children of participants in the Washington Heights Inwood Columbia Aging Project (WHICAP), a community-based longitudinal study of cognitive aging and dementia in which participants are evaluated and diagnosed prospectively. Memory in the Offspring participants was evaluated with the Selective Reminding Test. A mixed design general linear model evaluated whether WMH volumes in the frontal, temporal, parietal, and occipital lobes differed in participants with and without a parental history of dementia. A mediation analysis examined whether increased WMH volumes mediated the association between a parental history of dementia and cognition in a subset of Offspring participants. Results: Of the Offspring participants included, 214 (34%) had a parent with a diagnosis of dementia. Participants with a parent with history of dementia had greater overall WMH volume (main effect of parental diagnosis: F=3.58, p=0.05) and greater WMH volume in the parietal (t=2.18, p=0.02) and occipital (t=3.05, p=0.003) lobes (Parental Diagnosis x Region: F=2.71, p=0.04). In a subset of the participants with available neuropsychological test scores (n=466) those with a parental history of dementia had lower memory scores than those without a parental history of dementia (B=-1.42, 95% CI [-1.59,-1.26], p<0.001), but WMH volume did not mediate this relationship (ACME=-0.00189; 95% CI [-0.01269, 0.01]; p=0.77) in models adjusted for participant age and education. Conclusions: Middle-aged adults with parental history of dementia have increased WMH volume, particularly in parietal regions, an anatomical pattern associated with risk and progression of AD. However, WMH do not mediate the relationship between parental diagnosis of dementia and memory. The results highlight the possibility that dementia risk is partially transmitted intergenerationally via cerebrovascular disease pathways, but additional research is needed to determine whether this risk may manifest as cognitive impairment later in life.

Poster

02/15/2024
08:00 am - 09:15 am
Room: Majestic Complex (Posters 61-120)

Poster Session 02: Aging | MCI | Neurodegenerative Disease - PART 1

Final Abstract #102

Prospective Parental Diagnosis of Dementia is Associated White Matter Hyperintensities in Middle Age

Rafael Lippert, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States
Jeffrey Pyne, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States
Indira Turney, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States
Patrick Lao, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States
A. Zarina Kraal, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States
Natalie Edwards, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States
Mohamad Alshikho, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States
Joncarlos Berroa, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States
Jose Gutierrez, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States
Richard Mayeux, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States
Jennifer Manly, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States
Adam Brickman, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, United States

Category: Dementia (Alzheimer's Disease)

Keyword 1: dementia - Alzheimer's disease
Keyword 2: vascular cognitive impairment
Keyword 3: memory disorders

Objective:

Cerebrovascular disease is associated with risk for dementia and possibly Alzheimer’s disease (AD) pathogenesis. Parental history of dementia and white matter hyperintensities (WMH), a marker of small vessel cerebrovascular disease, are both risk factors for AD. In the current study, we examined whether parental history of dementia is associated with WMH and whether WMH mediate the association of parental dementia history with cognition in middle-aged adults.

Participants and Methods:

Six hundred thirty-eight middle-aged participants (mean+SD age=54.4+10.5, 65% women, 70% Latinx, 21% Black, 9% non-Latinx White) in the Offspring Study received MRI. Offspring Study participants are the adult children of participants in the Washington Heights Inwood Columbia Aging Project (WHICAP), a community-based longitudinal study of cognitive aging and dementia in which participants are evaluated and diagnosed prospectively. Memory in the Offspring participants was evaluated with the Selective Reminding Test. A mixed design general linear model evaluated whether WMH volumes in the frontal, temporal, parietal, and occipital lobes differed in participants with and without a parental history of dementia. A mediation analysis examined whether increased WMH volumes mediated the association between a parental history of dementia and cognition in a subset of Offspring participants.

Results:

Of the Offspring participants included, 214 (34%) had a parent with a diagnosis of dementia. Participants with a parent with history of dementia had greater overall WMH volume (main effect of parental diagnosis: F=3.58, p=0.05) and greater WMH volume in the parietal (t=2.18, p=0.02) and occipital (t=3.05, p=0.003) lobes (Parental Diagnosis x Region: F=2.71, p=0.04). In a subset of the participants with available neuropsychological test scores (n=466) those with a parental history of dementia had lower memory scores than those without a parental history of dementia (B=-1.42, 95% CI [-1.59,-1.26], p<0.001), but WMH volume did not mediate this relationship (ACME=-0.00189; 95% CI [-0.01269, 0.01]; p=0.77) in models adjusted for participant age and education.

Conclusions:

Middle-aged adults with parental history of dementia have increased WMH volume, particularly in parietal regions, an anatomical pattern associated with risk and progression of AD. However, WMH do not mediate the relationship between parental diagnosis of dementia and memory. The results highlight the possibility that dementia risk is partially transmitted intergenerationally via cerebrovascular disease pathways, but additional research is needed to determine whether this risk may manifest as cognitive impairment later in life.