INS NYC 2024 Program

Poster	Poster Session 02 Program Schedule 02/15/2024 08:00 am - 09:15 am Room: Majestic Complex (Posters 61-120) Poster Session 02: Aging \| MCI \| Neurodegenerative Disease - PART 1 Final Abstract #98 WAIS-IV Subtest Profiles in MCI Subtypes and Dementia Laura Glass Umfleet, Medical College of Wisconsin, Milwaukee, United States Russell Bauer, University of Florida, Gainesville, United States David Loring, Emory University School of Medicine, Atlanta, United States Jude Henry, Medical College of Wisconsin, Milwaukee, United States Jordan Schwartz, University of California Los Angeles, Los Angeles, United States Steven Reise, University of California Los Angeles, Los Angeles, United States Kristen Enriquez, University of California Los Angeles, Los Angeles, United States Daniel Drane, Emory University School of Medicine, Atlanta, United States Lucia Cavanaugh, University of California Los Angeles, Los Angeles, United States Joseph Gullett, University of Florida, Gainesville, United States Emily Carter, University of Florida, Gainesville, United States Lisa Drozdick, Pearson, San Antonio, United States Robert Bilder, University of California Los Angeles, Los Angeles, United States Category: MCI (Mild Cognitive Impairment) Keyword 1: assessment Keyword 2: neuropsychological assessment Keyword 3: memory disorders Objective: WAIS-IV clinical validity samples of individuals with Alzheimer’s disease (AD; n ≤ 42) and mild cognitive impairment (MCI, n ≤ 59) reveal subtest group differences compared to demographically matched healthy controls. The Information subtest, often considered a “hold” test, had the second highest effect size for subtest differences between AD and controls. The MCI cohort did not significantly differ from controls on IN but differed on Coding and PRI subtests (ES range .50 to .66), possibly related to the inclusion of both amnestic and non-amnestic subtypes. The Information subtest examines general factual knowledge, and is arguably a measure of semantic memory, a common deficit in AD. Here we report the WAIS-IV profiles to evaluate amnestic and non-amnestic subtype differences with the hypothesis that Information will be the lowest VCI subtest score in amnestic subtypes at both the MCI and dementia stages. Participants and Methods: Participant data were exported from the National Neuropsychology Network data repository. Out of 11033 participants with available ICD-10 diagnoses, 947 (54% female, 83% white, age range 18 to 90+) were clinically diagnosed with the following conditions of interest: MCI (n = 403), dementia (n = 142), and unspecified neurocognitive disorder (n = 402). Participants in all groups were divided into “amnestic” and “non-amnestic” subtypes using the psychometric component of Petersen’s criteria (≥ 1.5SD below the normative mean on at least one memory measure), using delayed recall from one or more of the following tests: the WMS-IV Logical Memory and Verbal Paired Associates subtests, CVLT-3, and HVLT-R. We conducted ANOVA analyses to compare amnestic and non-amnestic groups across WAIS-IV subtests. The Games-Howell correction for multiple comparisons was applied. Results: Significantly lower scores were seen on Matrix Reasoning, Digit Span, Information, and Similarities in aMCI compared to naMCI. In the dementia group, the Information mean difference scores approached significance in the amnestic v. non-amnestic subgroup (p = .085). In the unspecified diagnostic group, the amnestic subgroup had significantly lower scores on all WAIS-IV subtests. The IN subtest was the lowest VCI subtest mean score in all amnestic groups. For a subset of participants, neurodegenerative etiology was specified (i.e., AD n = 66, cerebrovascular disease n = 45, and PD/Lewy Body n = 16). Trend-level results emerged with lower mean scores on the Information subtest in the AD versus PD/Lewy Body group (p = .06). While not significant, the AD group had a lower mean score than the cerebrovascular group. Conclusions: Differences emerged in WAIS-IV subtest profiles between amnestic and non-amnestic groups. Findings indicate that the Information subtest is a useful test as part of a workup for amnestic syndromes, prior to the dementia stage, and that its status as a “hold” test should be reassessed.

Poster

02/15/2024
08:00 am - 09:15 am
Room: Majestic Complex (Posters 61-120)

Poster Session 02: Aging | MCI | Neurodegenerative Disease - PART 1

Final Abstract #98

WAIS-IV Subtest Profiles in MCI Subtypes and Dementia

Laura Glass Umfleet, Medical College of Wisconsin, Milwaukee, United States
Russell Bauer, University of Florida, Gainesville, United States
David Loring, Emory University School of Medicine, Atlanta, United States
Jude Henry, Medical College of Wisconsin, Milwaukee, United States
Jordan Schwartz, University of California Los Angeles, Los Angeles, United States
Steven Reise, University of California Los Angeles, Los Angeles, United States
Kristen Enriquez, University of California Los Angeles, Los Angeles, United States
Daniel Drane, Emory University School of Medicine, Atlanta, United States
Lucia Cavanaugh, University of California Los Angeles, Los Angeles, United States
Joseph Gullett, University of Florida, Gainesville, United States
Emily Carter, University of Florida, Gainesville, United States
Lisa Drozdick, Pearson, San Antonio, United States
Robert Bilder, University of California Los Angeles, Los Angeles, United States

Category: MCI (Mild Cognitive Impairment)

Keyword 1: assessment
Keyword 2: neuropsychological assessment
Keyword 3: memory disorders

Objective:

WAIS-IV clinical validity samples of individuals with Alzheimer’s disease (AD; n ≤ 42) and mild cognitive impairment (MCI, n ≤ 59) reveal subtest group differences compared to demographically matched healthy controls. The Information subtest, often considered a “hold” test, had the second highest effect size for subtest differences between AD and controls. The MCI cohort did not significantly differ from controls on IN but differed on Coding and PRI subtests (ES range .50 to .66), possibly related to the inclusion of both amnestic and non-amnestic subtypes. The Information subtest examines general factual knowledge, and is arguably a measure of semantic memory, a common deficit in AD. Here we report the WAIS-IV profiles to evaluate amnestic and non-amnestic subtype differences with the hypothesis that Information will be the lowest VCI subtest score in amnestic subtypes at both the MCI and dementia stages.

Participants and Methods:

Participant data were exported from the National Neuropsychology Network data repository. Out of 11033 participants with available ICD-10 diagnoses, 947 (54% female, 83% white, age range 18 to 90+) were clinically diagnosed with the following conditions of interest: MCI (n = 403), dementia (n = 142), and unspecified neurocognitive disorder (n = 402). Participants in all groups were divided into “amnestic” and “non-amnestic” subtypes using the psychometric component of Petersen’s criteria (≥ 1.5SD below the normative mean on at least one memory measure), using delayed recall from one or more of the following tests: the WMS-IV Logical Memory and Verbal Paired Associates subtests, CVLT-3, and HVLT-R. We conducted ANOVA analyses to compare amnestic and non-amnestic groups across WAIS-IV subtests. The Games-Howell correction for multiple comparisons was applied.

Results:

Significantly lower scores were seen on Matrix Reasoning, Digit Span, Information, and Similarities in aMCI compared to naMCI. In the dementia group, the Information mean difference scores approached significance in the amnestic v. non-amnestic subgroup (p = .085). In the unspecified diagnostic group, the amnestic subgroup had significantly lower scores on all WAIS-IV subtests. The IN subtest was the lowest VCI subtest mean score in all amnestic groups. For a subset of participants, neurodegenerative etiology was specified (i.e., AD n = 66, cerebrovascular disease n = 45, and PD/Lewy Body n = 16). Trend-level results emerged with lower mean scores on the Information subtest in the AD versus PD/Lewy Body group (p = .06). While not significant, the AD group had a lower mean score than the cerebrovascular group.

Conclusions:

Differences emerged in WAIS-IV subtest profiles between amnestic and non-amnestic groups. Findings indicate that the Information subtest is a useful test as part of a workup for amnestic syndromes, prior to the dementia stage, and that its status as a “hold” test should be reassessed.