INS NYC 2024 Program

Poster	Poster Session 02 Program Schedule 02/15/2024 08:00 am - 09:15 am Room: Majestic Complex (Posters 61-120) Poster Session 02: Aging \| MCI \| Neurodegenerative Disease - PART 1 Final Abstract #95 Associations Between Self-Reported and Neuropsychological Measures of Impulsivity in Parkinson's Disease Shelby Stohlman, Mass General Brigham, Boston, United States Sigurros Davidsdottir, Mass General Brigham, Boston, United States Lauren Pollak, Mass General Brigham, Boston, United States Category: Movement and Movement Disorders Keyword 1: Parkinson's disease Objective: Impulsivity refers to difficulty inhibiting unwanted behaviors or actions performed without anticipation of future consequences that have the potential to harm oneself or others. Individuals with Parkinson’s disease (PD) experience higher rates of impulsivity than those in the general population, which contributes to increased caregiver burden and reduced quality of life. However, it is challenging to obtain objective measures of impulsivity in PD. While the Questionnaire for Impulsive-Compulsive Disorders in PD (QUIP) is a commonly used screening measure for the detection of impulse control disorders and associated behaviors in PD, the relationship between scores on the QUIP and performances on commonly-used neuropsychological measures of impulsivity in individuals with PD is unclear. The primary purpose of this study is to examine the association between self-reported ratings of impulsivity with neuropsychological measures of impulsivity in individuals with PD. The secondary purpose of this study is to examine the associations between QUIP scores with disease characteristics and other neuropsychiatric symptoms. Participants and Methods: We conducted a retrospective study analyzing the records of 109 patients with PD who were part of a pre-surgical deep brain stimulation cohort. Patients were evaluated using the QUIP, Mini-Mental State Examination (MMSE), Trail Making Test, Stroop Color and Word Test, Geriatric Depression Scale (GDS, short form), and Parkinson’s Anxiety Scale (PAS). Correlations and T-test analyses were conducted to examine associations between QUIP scores and demographic factors, disease characteristics, cognition, and mood symptoms in order to determine which elements should be included in a regression model. Subsequently, four-stage hierarchical regressions investigated the association between QUIP total scores and disease characteristics, mood symptoms, scores on the MMSE, and performance on neuropsychological measures of impulsivity (i.e., whether individuals made errors on the Trail Making Test and the Stroop Color Word Interference scaled score). Results: On average, participants were 70.1-years-old, had 15.44 years of education, had PD duration of 10 years and were predominantly male (67.1%). Descriptively, 1.8% met criteria for pathological gambling, 5.5% met criteria for hypersexuality, 6.4% met criteria for pathological buying, 7.3% met criteria for compulsive eating, and 28.4% met criteria for significant punding/hobbyism. Correlation analyses revealed significant associations between QUIP total scores and GDS and PAS scores. Student T-Tests showed that individuals taking dopamine agonists endorsed more impulsive symptoms on the QUIP. Hierarchical regressions revealed that QUIP total scores were associated with total scores on the PAS. There were no significant relationships between QUIP total scores and errors on the Trail Making Test, Stroop Color-Word Interference scaled scores, MMSE scores, disease characteristics, GDS scores, and whether the patient was taking a dopamine agonist. Conclusions: This exploratory study suggests self-reported impulsivity scores are not associated with commonly used neuropsychological measures that assess impulsive responding in PD patients. This may suggest a disconnect between patients’ insight into their impulsive responding and their scores or objective measures. Alternatively, the findings from this study could indicate that these neuropsychological measures do not fully capture impulsivity in PD. This warrants future careful consideration of tests aimed at assessing impulsivity in PD.

Poster

02/15/2024
08:00 am - 09:15 am
Room: Majestic Complex (Posters 61-120)

Poster Session 02: Aging | MCI | Neurodegenerative Disease - PART 1

Final Abstract #95

Associations Between Self-Reported and Neuropsychological Measures of Impulsivity in Parkinson's Disease

Shelby Stohlman, Mass General Brigham, Boston, United States
Sigurros Davidsdottir, Mass General Brigham, Boston, United States
Lauren Pollak, Mass General Brigham, Boston, United States

Category: Movement and Movement Disorders

Keyword 1: Parkinson's disease

Objective:

Impulsivity refers to difficulty inhibiting unwanted behaviors or actions performed without anticipation of future consequences that have the potential to harm oneself or others. Individuals with Parkinson’s disease (PD) experience higher rates of impulsivity than those in the general population, which contributes to increased caregiver burden and reduced quality of life. However, it is challenging to obtain objective measures of impulsivity in PD. While the Questionnaire for Impulsive-Compulsive Disorders in PD (QUIP) is a commonly used screening measure for the detection of impulse control disorders and associated behaviors in PD, the relationship between scores on the QUIP and performances on commonly-used neuropsychological measures of impulsivity in individuals with PD is unclear. The primary purpose of this study is to examine the association between self-reported ratings of impulsivity with neuropsychological measures of impulsivity in individuals with PD. The secondary purpose of this study is to examine the associations between QUIP scores with disease characteristics and other neuropsychiatric symptoms.

Participants and Methods:

We conducted a retrospective study analyzing the records of 109 patients with PD who were part of a pre-surgical deep brain stimulation cohort. Patients were evaluated using the QUIP, Mini-Mental State Examination (MMSE), Trail Making Test, Stroop Color and Word Test, Geriatric Depression Scale (GDS, short form), and Parkinson’s Anxiety Scale (PAS). Correlations and T-test analyses were conducted to examine associations between QUIP scores and demographic factors, disease characteristics, cognition, and mood symptoms in order to determine which elements should be included in a regression model. Subsequently, four-stage hierarchical regressions investigated the association between QUIP total scores and disease characteristics, mood symptoms, scores on the MMSE, and performance on neuropsychological measures of impulsivity (i.e., whether individuals made errors on the Trail Making Test and the Stroop Color Word Interference scaled score).

Results:

On average, participants were 70.1-years-old, had 15.44 years of education, had PD duration of 10 years and were predominantly male (67.1%). Descriptively, 1.8% met criteria for pathological gambling, 5.5% met criteria for hypersexuality, 6.4% met criteria for pathological buying, 7.3% met criteria for compulsive eating, and 28.4% met criteria for significant punding/hobbyism. Correlation analyses revealed significant associations between QUIP total scores and GDS and PAS scores. Student T-Tests showed that individuals taking dopamine agonists endorsed more impulsive symptoms on the QUIP. Hierarchical regressions revealed that QUIP total scores were associated with total scores on the PAS. There were no significant relationships between QUIP total scores and errors on the Trail Making Test, Stroop Color-Word Interference scaled scores, MMSE scores, disease characteristics, GDS scores, and whether the patient was taking a dopamine agonist.

Conclusions:

This exploratory study suggests self-reported impulsivity scores are not associated with commonly used neuropsychological measures that assess impulsive responding in PD patients. This may suggest a disconnect between patients’ insight into their impulsive responding and their scores or objective measures. Alternatively, the findings from this study could indicate that these neuropsychological measures do not fully capture impulsivity in PD. This warrants future careful consideration of tests aimed at assessing impulsivity in PD.